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View Structure Prediction Details

Protein: comr-PA
Organism: Drosophila melanogaster
Length: 600 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for comr-PA.

Description E-value Query
Range
Subject
Range
gi|21428772 - gi|21428772|gb|AAM50105.1| AT27686p [Drosophila melanogaster]
1133.0 [0..1] [600..1]

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Predicted Domain #1
Region A:
Residues: [1-102]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGNQDTLGQ SQQVNESGDE YEEDAATSWT NELEQQESRT PADSPEFLDF VDSEDPLEDF  60
   61 ERNPLQKEPL DLAVKPVSDI NKKAAENHRR IYRQLGIHIP ET

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [103-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKSHPLLHYA FVVKLFLATD NSSIHYLKWS ANGRELEVDY QGMQEHLSSG CSMFHCRNTL  60
   61 QFTGTLLAHG FERVSLKDVR KSSATNITLI YRNPNFVKGQ LLKLHKLAQE CEKIPEISSP 120
  121 GTAEPRRPPL 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.43
Match: 1hksA
Description: SOLUTION STRUCTURE OF THE DNA-BINDING DOMAIN OF DROSOPHILA HEAT SHOCK TRANSCRIPTION FACTOR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.23858959608048 bayes_pls_golite062009
DNA binding 4.78517210147551 bayes_pls_golite062009
nucleic acid binding 4.72059012764202 bayes_pls_golite062009
transcription factor activity 4.02736190679869 bayes_pls_golite062009
transcription activator activity 3.46623224639317 bayes_pls_golite062009
binding 3.37660003833383 bayes_pls_golite062009
sequence-specific DNA binding 3.31558616762587 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.41045867230388 bayes_pls_golite062009
transcription repressor activity 1.9708626903609 bayes_pls_golite062009
protein binding 1.77689943618029 bayes_pls_golite062009
transcription factor binding 0.752335897765285 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.490809930581315 bayes_pls_golite062009
structural molecule activity 0.128347187436068 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.0406721670764369 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [233-404]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLPNYAHISR MVRRGDLCST PYTSRSALQV ARCHFQTLLG YQADLGVLKD RNNHDMFNKN  60
   61 IMTQLNVKRG RSSINNAPVD LAPSKVSFEK FVKPHESVIN IGIGQAPDYA GYYGQVELFK 120
  121 VNEFFSEYLP RYGSKITGYK EIVMDATNKS IGFQQNLPIG MNYSDDEDDA LP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [405-600]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PISSDLDLDF MPSTSAAAKM KSTGRKVVED SDLEQAMQEL CGGSNLNEEE ELPQTSTRFK  60
   61 AKPKPRAKTK AKPTKRQAKP VHSSSSECED FKPDEVYEGF KSRNPKNVKL KPSDENISYT 120
  121 LEEGTDFEEQ VIEETTETKV QDSQYDDLDD DDDDEEEDYF DEDDEDYVYK NLQYRNPPEP 180
  181 PKSRRYDLRN SKRNPR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle