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View Structure Prediction Details

Protein: casp-PB, casp-PA
Organism: Drosophila melanogaster
Length: 695 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for casp-PB, casp-PA.

Description E-value Query
Range
Subject
Range
FAF1_MOUSE - FAS-associated factor 1 OS=Mus musculus GN=Faf1 PE=1 SV=2
626.0 [0..1] [695..1]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSENKDEALT SFQSITGIDD VGEAFSHLEA ADWNLVEALS RVIPHEDAPL TSPHPILVPE  60
   61 PPARNAVEST NGFRP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.55
Match: 2damA
Description: No description for 2damA was found.

Predicted Domain #2
Region A:
Residues: [76-148]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGFDEMPGTS NASGFFAAAL QNQNQNLNLN QPHIQQRFPT SQLLAQLTSS INLDPASSQN  60
   61 NNQNVITFNI HFN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [149-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQLYQLRLPS EATVEQLKRK IFAETSVPVC RQAIRGWPPS KASDAQQLGT RLCNLDLSPE  60
   61 NELILVDLTE DGFMDTEQDE VTQRVDKDFT IFIQFESDPP LTLSLPGRMT VQEVKMNVFD 120
  121 IKSIPVRHQE WTGWPNGCDN DTTLAQSGIG LSHRFAVRST ERSAPTNSNQ HNAFDVVTVD 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.154902
Match: 1z2mA
Description: Crystal Structure of ISG15, the Interferon-Induced Ubiquitin Cross Reactive Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.9188688008729 bayes_pls_golite062009
binding 2.786655943372 bayes_pls_golite062009
small conjugating protein ligase activity 2.06714283858345 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.48147454986498 bayes_pls_golite062009
transcription regulator activity 1.42747465816672 bayes_pls_golite062009
nucleic acid binding 1.32707653701567 bayes_pls_golite062009
DNA binding 1.22622447288034 bayes_pls_golite062009
acid-amino acid ligase activity 1.0818414663245 bayes_pls_golite062009
signal transducer activity 1.05682194741929 bayes_pls_golite062009
molecular transducer activity 1.05682194741929 bayes_pls_golite062009
hydrolase activity 0.614233748923048 bayes_pls_golite062009
GTPase regulator activity 0.334601927012824 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.315664702789604 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.209042683238025 bayes_pls_golite062009
enzyme regulator activity 0.162163146322721 bayes_pls_golite062009
receptor signaling protein activity 0.119687312084129 bayes_pls_golite062009
receptor binding 0.020939932812017 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [329-511]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SESSTDEFED ATDFNNAEYI FTDSPPAQPP NRHLIPNDTD DEISGSTQFV ENYKARYGEP  60
   61 CPEFFVGSLE NAKQLACLRS AKERKLLAIY LHHGKSILSN VFCDQLMKHE SIIQTFKEKF 120
  121 VLYGWDMTYE SNKDMFLSSL TACISSNASL TARNIKLDKL PAIMLVGKSR QLGSNCEVLS 180
  181 VIH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.522879
Match: 2dlxA
Description: No description for 2dlxA was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.51590630336241 bayes_pls_golite062009
antioxidant activity 1.41754012367769 bayes_pls_golite062009
binding 1.25802922431343 bayes_pls_golite062009
peroxidase activity 1.22546563390242 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 1.22546563390242 bayes_pls_golite062009
protein binding 1.18479617596618 bayes_pls_golite062009
signal transducer activity 1.03696928411308 bayes_pls_golite062009
molecular transducer activity 1.03696928411308 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
hydrolase activity 0.517269321619613 bayes_pls_golite062009
glutathione peroxidase activity 0.29729802281773 bayes_pls_golite062009
intramolecular oxidoreductase activity 0.13913802190798 bayes_pls_golite062009
peroxiredoxin activity 0.0343881005856616 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [512-615]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNIGLDDLLT RLIETCEMFE EQLQVEIRQE DERAARDQVK AEQDMAYQET LQADMAKDAA  60
   61 KRQKEAAQLA ERKRMESERA EEDARRESIR LVAQQSLPQE PSEQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.39794
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #6
Region A:
Residues: [616-695]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETGTSKIRVR KPTGDFLERR FFINNNLQDL LNFVTANGFL IEEYKLISSW PRRDLTAIES  60
   61 SQTLESLKLY PQETVILEER 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 1h8cA
Description: Fas-assosiated factor 1, Faf1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.9188688008729 bayes_pls_golite062009
binding 2.786655943372 bayes_pls_golite062009
small conjugating protein ligase activity 2.06714283858345 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.48147454986498 bayes_pls_golite062009
transcription regulator activity 1.42747465816672 bayes_pls_golite062009
nucleic acid binding 1.32707653701567 bayes_pls_golite062009
DNA binding 1.22622447288034 bayes_pls_golite062009
acid-amino acid ligase activity 1.0818414663245 bayes_pls_golite062009
signal transducer activity 1.05682194741929 bayes_pls_golite062009
molecular transducer activity 1.05682194741929 bayes_pls_golite062009
hydrolase activity 0.614233748923048 bayes_pls_golite062009
GTPase regulator activity 0.334601927012824 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.315664702789604 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.209042683238025 bayes_pls_golite062009
enzyme regulator activity 0.162163146322721 bayes_pls_golite062009
receptor signaling protein activity 0.119687312084129 bayes_pls_golite062009
receptor binding 0.020939932812017 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle