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View Structure Prediction Details

Protein: casp-PB, casp-PA
Organism: Drosophila melanogaster
Length: 695 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for casp-PB, casp-PA.

Description E-value Query
Range
Subject
Range
FAF1_MOUSE - FAS-associated factor 1 OS=Mus musculus GN=Faf1 PE=1 SV=2
626.0 [0..1] [695..1]

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Predicted Domain #1
Region A:
Residues: [1-75]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSENKDEALT SFQSITGIDD VGEAFSHLEA ADWNLVEALS RVIPHEDAPL TSPHPILVPE  60
   61 PPARNAVEST NGFRP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.55
Match: 2damA
Description: No description for 2damA was found.

Predicted Domain #2
Region A:
Residues: [76-148]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGFDEMPGTS NASGFFAAAL QNQNQNLNLN QPHIQQRFPT SQLLAQLTSS INLDPASSQN  60
   61 NNQNVITFNI HFN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [149-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQLYQLRLPS EATVEQLKRK IFAETSVPVC RQAIRGWPPS KASDAQQLGT RLCNLDLSPE  60
   61 NELILVDLTE DGFMDTEQDE VTQRVDKDFT IFIQFESDPP LTLSLPGRMT VQEVKMNVFD 120
  121 IKSIPVRHQE WTGWPNGCDN DTTLAQSGIG LSHRFAVRST ERSAPTNSNQ HNAFDVVTVD 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.154902
Match: 1z2mA
Description: Crystal Structure of ISG15, the Interferon-Induced Ubiquitin Cross Reactive Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.9188688008729 bayes_pls_golite062009
binding 2.786655943372 bayes_pls_golite062009
small conjugating protein ligase activity 2.06714283858345 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.48147454986498 bayes_pls_golite062009
transcription regulator activity 1.42747465816672 bayes_pls_golite062009
nucleic acid binding 1.32707653701567 bayes_pls_golite062009
DNA binding 1.22622447288034 bayes_pls_golite062009
acid-amino acid ligase activity 1.0818414663245 bayes_pls_golite062009
signal transducer activity 1.05682194741929 bayes_pls_golite062009
molecular transducer activity 1.05682194741929 bayes_pls_golite062009
hydrolase activity 0.614233748923048 bayes_pls_golite062009
GTPase regulator activity 0.334601927012824 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.315664702789604 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.209042683238025 bayes_pls_golite062009
enzyme regulator activity 0.162163146322721 bayes_pls_golite062009
receptor signaling protein activity 0.119687312084129 bayes_pls_golite062009
receptor binding 0.020939932812017 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [329-511]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SESSTDEFED ATDFNNAEYI FTDSPPAQPP NRHLIPNDTD DEISGSTQFV ENYKARYGEP  60
   61 CPEFFVGSLE NAKQLACLRS AKERKLLAIY LHHGKSILSN VFCDQLMKHE SIIQTFKEKF 120
  121 VLYGWDMTYE SNKDMFLSSL TACISSNASL TARNIKLDKL PAIMLVGKSR QLGSNCEVLS 180
  181 VIH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.522879
Match: 2dlxA
Description: No description for 2dlxA was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.51590630336241 bayes_pls_golite062009
antioxidant activity 1.41754012367769 bayes_pls_golite062009
binding 1.25802922431343 bayes_pls_golite062009
peroxidase activity 1.22546563390242 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 1.22546563390242 bayes_pls_golite062009
protein binding 1.18479617596618 bayes_pls_golite062009
signal transducer activity 1.03696928411308 bayes_pls_golite062009
molecular transducer activity 1.03696928411308 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
hydrolase activity 0.517269321619613 bayes_pls_golite062009
glutathione peroxidase activity 0.29729802281773 bayes_pls_golite062009
intramolecular oxidoreductase activity 0.13913802190798 bayes_pls_golite062009
peroxiredoxin activity 0.0343881005856616 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [512-615]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNIGLDDLLT RLIETCEMFE EQLQVEIRQE DERAARDQVK AEQDMAYQET LQADMAKDAA  60
   61 KRQKEAAQLA ERKRMESERA EEDARRESIR LVAQQSLPQE PSEQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.39794
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #6
Region A:
Residues: [616-695]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETGTSKIRVR KPTGDFLERR FFINNNLQDL LNFVTANGFL IEEYKLISSW PRRDLTAIES  60
   61 SQTLESLKLY PQETVILEER 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 1h8cA
Description: Fas-assosiated factor 1, Faf1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 2.9188688008729 bayes_pls_golite062009
binding 2.786655943372 bayes_pls_golite062009
small conjugating protein ligase activity 2.06714283858345 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.48147454986498 bayes_pls_golite062009
transcription regulator activity 1.42747465816672 bayes_pls_golite062009
nucleic acid binding 1.32707653701567 bayes_pls_golite062009
DNA binding 1.22622447288034 bayes_pls_golite062009
acid-amino acid ligase activity 1.0818414663245 bayes_pls_golite062009
signal transducer activity 1.05682194741929 bayes_pls_golite062009
molecular transducer activity 1.05682194741929 bayes_pls_golite062009
hydrolase activity 0.614233748923048 bayes_pls_golite062009
GTPase regulator activity 0.334601927012824 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.315664702789604 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.209042683238025 bayes_pls_golite062009
enzyme regulator activity 0.162163146322721 bayes_pls_golite062009
receptor signaling protein activity 0.119687312084129 bayes_pls_golite062009
receptor binding 0.020939932812017 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle