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View Structure Prediction Details

Protein: psq-PA
Organism: Drosophila melanogaster
Length: 1046 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for psq-PA.

Description E-value Query
Range
Subject
Range
gi|1149500, gi|2... - pir||S66149 gene pipsqueak protein A long form - fruit fly (Drosophila melanogaster), gi|1149500|em...
637.0 [0..605] [1043..605]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAVRGHQYF SLRWNNYQNT MTSVFQQLRE DLSFVDVTLS CEHGSLKAHK VVLSACSTYF  60
   61 QKLLLENPCK HPTIILPADI IFTDLKTIID FVYRGEIDVT ESELQGLLRT AEQLKIKGLC 120
  121 ETAENADDLN DAATATI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 2ihcA
Description: No description for 2ihcA was found.

Predicted Domain #2
Region A:
Residues: [138-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVSENIQQAV VGNIVNAAIV PGAPSPSLEQ QQQHHQQQQQ QQAQEQHQQQ QVHAQQQQQQ  60
   61 QQQINAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [205-310]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLTQHGVSSG SVSLSGQLLS SSASGSSGSL AGGQQASQTP SGLQPTPRKS RLKRSKSPDL  60
   61 SSGGGAGSSG GSSSGSTQQQ PQPAHHHHPQ TILIQGQNPN SIVSLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.39794
Match: 2dlqA
Description: No description for 2dlqA was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [311-440]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTADGNYIPV SGSGDDSDAE DHEHEHNHGH GHGHGGHTHG HGHSHEHSHD HEHEHKPNKI  60
   61 CKTEHSVASP ASNSSSASNN AAGVSGVTST GQAIVTQIVV ARDGKDTKNM TSLGMGMNGG 120
  121 LLGVPMGFLD 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.0
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #5
Region A:
Residues: [441-609]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTPEPPAPSA TPVTVTEHVD LSCNPSTDTR DLSNTTEPLD IDNHLAQQIH RLDQSPMHSI  60
   61 SHHHTGDESN SNLVQHIKSE VIEAKHLAAQ HHALSQAQQQ HAHHQAHQQH QQHQQQQHQQ 120
  121 QQQHLHAQQL LAQSQLQQQQ QQQQQQQQHH QQQQQQAAAA AAAAGVHGQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.221849
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [610-670]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGGHVTHADI GGATVMEIDP SQIKHEPGMI ITPEIVNMMS SGHMDMYNSD TSEDSMMIAN  60
   61 G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [671-917]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPHDQKEPHY TNLDQQHGLG GSVCGPGPGG AGGGGGMSGG AGSGSGEKDA LKNQNMSLTK  60
   61 ASAIYGIPST TLWQRAHRMG IETPKKEGGT KSWNEDALQN ALEALRSGQI SANKASKAFG 120
  121 IPSSTLYKIA RREGIRLAAP FNAAPTTWTP EDLERALEAI RAGNTSVQKA SAEFGIPTGT 180
  181 LYGRCKREGI ELSRSNPTPW SEDAMNEALN SVRVGQMSIN QAAIHYNLPY SSLYGRFKRG 240
  241 KYDVVAN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.08
Match: 2q1zA
Description: No description for 2q1zA was found.

Predicted Domain #8
Region A:
Residues: [918-1046]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSGVALLNTS GNTTGSIEII EHSQENSLHM LQQQFPYSPS PHPPTPQHHS TPQHHSSAQQ  60
   61 GPPTPQHMQQ HVVHMQQQQQ QQQQQSPHPG HHPQHMQQDV VTSSSQVVHS QQQQQLQQIY 120
  121 QHHGTPERS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle