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View Structure Prediction Details

Protein: Caf1-105-PA
Organism: Drosophila melanogaster
Length: 747 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Caf1-105-PA.

Description E-value Query
Range
Subject
Range
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=...
gi|25530855 - pir||AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)
502.0 [0..8] [561..901]

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Predicted Domain #1
Region A:
Residues: [1-429]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKCKIPEISW HNRDPVLSVD IQQNGLGLRS PTICRLASGG SDAHVLIWYV NRSDDAEGVD  60
   61 VELAADLSRH QRAVNAVRWS PNGELLASGD DESVVFIWKQ KADHEVVNIV DADGCSEQDK 120
  121 EVWLTLKVLR GHREDIYDLS WAPNSQFLVS GSVDNTAMLW DVHSGKSLAI LDDHKGYVQG 180
  181 VAWDPCNQYI ATMSTDRQMR IFDANTKRVL HRVSKCVLPV KEDHEMHGKS MRLYQDGTLQ 240
  241 TFFRRLCFTP DGKLLLTPSG ITDYDGVVKP INTSYGFSRH DLSKPAFVLP FPKEYAVAVR 300
  301 CSPVLYRLRP YNAEKNPPII SLPYRMIYAV ATKNAVFFYD TQQPVPFAIV SNIHYSRLTD 360
  361 LAWSSDGTVL IVSSTDGYCS LITFEPTELG DCYEDMETVL SVVLKSSENA TVLKKKRQKL 420
  421 RKVSLDEPR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.39794
Match: 1vyhC
Description: PAF-AH Holoenzyme: Lis1/Alfa2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 2.79445416141967 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
transcription repressor activity 2.29049708962212 bayes_pls_golite062009
dynein binding 1.74989209255308 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
transcription corepressor activity 1.41752877005447 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
cytoskeletal protein binding 1.19593750149343 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
0.88172763425403 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
DNA-dependent ATPase activity 0.625780732991652 bayes_pls_golite062009
actin binding 0.529861581509437 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
snoRNA binding 0.347797037104681 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
DNA helicase activity 0.220747580531792 bayes_pls_golite062009
structural molecule activity 0.0936365746095786 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [430-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPLQEKSKPN TIRRASEAGI TEVGEPELDA ENDSSTHSVS SNKTNSPKTK ASEEEKPTPI  60
   61 AIRRSPRKNS TAPMPIAIRR APRKPEDKGN SESS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [524-747]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPKDEMEVTH TKTTQVQKTV ASPVKRKVST EAVPPAETSQ PALAVIPVFE KEIISSDDKF  60
   61 ESPEKKSRPA TPIQVRRQPR TPGSSSQFNL TPKSQPAKQA TPIAVRRTPR VLIEMPVNSP 120
  121 VVPMEEAMDA WPLDESITPL PATKKDSRKP LPETVKTETK PAVIEASEAT CERTEDIRLV 180
  181 YEDTQEETPK NPTESGPSTP NNKTPRRVSL RTISTPKSKK KLLE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle