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View Structure Prediction Details

Protein: sns-PA
Organism: Drosophila melanogaster
Length: 1479 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sns-PA.

Description E-value Query
Range
Subject
Range
gi|8572742 - gi|8572742|gb|AAF77184.1| SNS [Drosophila melanogaster]
801.0 [0..36] [1479..38]

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Predicted Domain #1
Region A:
Residues: [1-206]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALQQQHQRH QQHQQHQQQQ QQQQQQQHIK WQQHATKRRR CRQHWIKHLQ LLRLLAVIVL  60
   61 ASAPVPSHAQ QQKFRTTPHD LQVLEGAEAM MRCEVANVAG AVQWTKDGFA LGFSAVIPGF 120
  121 PRYSVLGDRK QGIYNLRISN ASINDDADYQ CQVGPARLNS AIRANAKLTV ISPPASIEIK 180
  181 GYSHNSKVEV RENQDLQLKC IVANAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 2c1oA
Description: ENAIIHis Fab fragment in the free form
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [207-846]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAAQIVWYRG NVEYKPEKRE DTVEESTAKR FTTTSSLKLK PGPDDDYTEY TCQARHKALS  60
   61 PDMPMRATVQ LSVLYPPGPP YIEGYSAGET LRRGQTVELM CRSRGGNPPA QLIWYKNGSQ 120
  121 IRMAYRTSGR LSENIYTFTA EAGDNKARFR CEASNVMSQN PLKAEVELSV LFAPTHVTVM 180
  181 GPTEARVGDI VPLTCTTAPS NPPAEIKWMV GGRQVRNATS KTIVSPEGGW TTTSNITAVV 240
  241 EPNKRSLVVI CHGLNMQLTE NVVSTHTINV LYPPAPPLIS GYMEGQIIPA GSVQKLLCVS 300
  301 SGGNPLATLT WYKNDKRINS VIRAADKSVS AEITILANVS DNQAQYRCEA SNSATEIPLF 360
  361 QSTTLSVHFA PETVKIRIEP EELRPGMEAT IICDSSSSNP PAKLSWWKDG IPIEGINNTS 420
  421 KPGLWGGTVS TLEFRVNVTQ EMNGQVYTCQ SANEALQRSA HEAVSLDVLY RPKFVPPPSS 480
  481 TAVGVEGESL QVSLQTRANP TPVTYKWTKD GTTIPQDGDH RIFADGGSLN FTRLHRDDAG 540
  541 IYSCSASNSQ GGATLNITVV VEYGTTIKSV SENIVVNPGE DAMLSCTVEG KPLTEEHVKW 600
  601 ERVGYDMTVK TSTTFANGTS YLHIKDAKRE DVGNFRCVAD 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.0
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [847-1061]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRVDNPTNRD ILLIVKFAPE IAKTPTLLRA ASGTGERGRL PCRAQGSPKP QFIWRQDKKD  60
   61 LPINRTYKYE VEERKIDSLT YESTLIVDKV APADYGAYEC VARNELGEAV ETVRLEITSQ 120
  121 PDPPLSLNIL NVTHDTVTLA WTPGFDGGLK ASYRVRYRMA DREQYKYIDG LPNSHKLTIG 180
  181 GLRMNTLYLF SVMSWNELGQ SSYLPDLARA ETKGL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.69897
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #4
Region A:
Residues: [1062-1178]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELMPAELTED SSNTPNLVII GISLAAFGFL LVNASLVAWF FVHQRRKKVA ETTNQPAKTA  60
   61 TIEMYAPSSY NDTVTGETLS SVSEKSESYS NEGSSQPEYI DEVRKKAAST YLVEGSD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.154902
Match: 1qg3A
Description: Integin beta-4 subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [1179-1346]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPPRYQKDG TLPVIYPNNV VNACTLPHPR HNNGSAAIHM TRDDQMLISK GVYIPSPSPA  60
   61 PPPDGSYYNM NSDRYLSYPP MEYPAALDFT AQPMPMAHLQ PMTVTSLATN GGPTLIGNGS 120
  121 VAAVAGGSGT LRRGILRGVV GVPQPDVTHH TSTVGGSPMQ MLHDLHPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1347-1479]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLSASTLTTS TTLNGSLPTA TATLPRQPHG ILKDPNRNKQ QQQQQQQQQQ QQQLQHQQQL  60
   61 LNASLVGVGV PVSAPLGSLQ ILNLPPASGG LGNNLLMTTN AFDPTTVGLS SFGAVSQAGG 120
  121 IPVAYTDADG HLV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.522879
Match: 2cqvA
Description: Solution structure of the eighth Ig-like domain of human myosin light chain kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antigen binding 6.15874156332332 bayes_pls_golite062009
receptor activity 3.17924100507291 bayes_pls_golite062009
signal transducer activity 3.10913345555941 bayes_pls_golite062009
molecular transducer activity 3.10913345555941 bayes_pls_golite062009
transmembrane receptor activity 2.91032591770004 bayes_pls_golite062009
binding 2.74708244886154 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
olfactory receptor activity 2.08021142115894 bayes_pls_golite062009
receptor binding 1.70260377709721 bayes_pls_golite062009
peptide antigen binding 1.66960790017756 bayes_pls_golite062009
cell adhesion molecule binding 1.36789541796983 bayes_pls_golite062009
IgG binding 1.27089907020716 bayes_pls_golite062009
protein complex binding 1.19581190330569 bayes_pls_golite062009
integrin binding 0.599569390248921 bayes_pls_golite062009
monosaccharide binding 0.533047672054027 bayes_pls_golite062009
immunoglobulin binding 0.48272957113121 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.323725749644669 bayes_pls_golite062009
MHC class II receptor activity 0.251167772391909 bayes_pls_golite062009
platelet-derived growth factor receptor binding 0.1619066412638 bayes_pls_golite062009
extracellular matrix structural constituent 0.0606967061070782 bayes_pls_golite062009
G-protein coupled receptor activity 0.01716416477363 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle