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View Structure Prediction Details

Protein: dpn-PA
Organism: Drosophila melanogaster
Length: 435 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dpn-PA.

Description E-value Query
Range
Subject
Range
gi|259772, gi|423828 - gi|423828|pir||A46231 helix-loop-helix protein Dpn - fruit fly (Drosophila sp.), gi|259772|gb|AAB241...
243.0 [0..1] [435..1]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYKNDINSD DDFDCSNGYS DSYGSNGRMS NPNGLSKAEL RKTNKPIMEK RRRARINHCL  60
   61 NELKSLILEA MKKDPARHTK LEKADILEMT VKHLQSVQRQ QLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.0
Match: 1an4A
Description: Usf B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
sequence-specific DNA binding 2.31910036997977 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
protein binding 1.59929864805879 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
promoter binding 0.8576109846276 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [104-203]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIQSDPSVV QKFKTGFVEC AEEVNRYVSQ MDGIDTGVRQ RLSAHLNQCA NSLEQIGSMS  60
   61 NFSNGYRGGL FPATAVTAAP TPLFPSLPQD LNNNSRTESS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 2db7A
Description: No description for 2db7A was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.32360164200263 bayes_pls_golite062009
DNA binding 4.02051725052534 bayes_pls_golite062009
nucleic acid binding 3.93314497121404 bayes_pls_golite062009
transcription factor activity 3.47415635303836 bayes_pls_golite062009
binding 3.22662593014843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.49509042716951 bayes_pls_golite062009
transcription repressor activity 2.02281452178123 bayes_pls_golite062009
protein binding 1.46569798429756 bayes_pls_golite062009
sequence-specific DNA binding 0.531186377572287 bayes_pls_golite062009
transcription factor binding 0.507261685411423 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [204-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APAIQMGGLQ LIPSRLPSGE FALIMPNTGS AAPPPGPFAW PGSAAGVAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [253-435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTASAALASI ANPTHLNDYT QSFRMSAFSK PVNTSVPANL PENLIHTLPG QTQLPVKNST  60
   61 SPPLSPISSI SSHCEESRAA SPTVDVMSKH SFAGVFSTPP PTSAETSFNT SGSLNLSAGS 120
  121 HDSSGCSRPL AHLQQQQVSS TSGIAKRDRE AEAESSDCSL DEPSSKKFLA GAIEKSSSAW 180
  181 RPW

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.09
Match: 2j63A
Description: No description for 2j63A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle