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View Structure Prediction Details

Protein: dpn-PA
Organism: Drosophila melanogaster
Length: 435 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dpn-PA.

Description E-value Query
Range
Subject
Range
gi|259772, gi|423828 - gi|423828|pir||A46231 helix-loop-helix protein Dpn - fruit fly (Drosophila sp.), gi|259772|gb|AAB241...
243.0 [0..1] [435..1]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYKNDINSD DDFDCSNGYS DSYGSNGRMS NPNGLSKAEL RKTNKPIMEK RRRARINHCL  60
   61 NELKSLILEA MKKDPARHTK LEKADILEMT VKHLQSVQRQ QLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.0
Match: 1an4A
Description: Usf B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
sequence-specific DNA binding 2.31910036997977 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
protein binding 1.59929864805879 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
promoter binding 0.8576109846276 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [104-203]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIQSDPSVV QKFKTGFVEC AEEVNRYVSQ MDGIDTGVRQ RLSAHLNQCA NSLEQIGSMS  60
   61 NFSNGYRGGL FPATAVTAAP TPLFPSLPQD LNNNSRTESS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 2db7A
Description: No description for 2db7A was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.32360164200263 bayes_pls_golite062009
DNA binding 4.02051725052534 bayes_pls_golite062009
nucleic acid binding 3.93314497121404 bayes_pls_golite062009
transcription factor activity 3.47415635303836 bayes_pls_golite062009
binding 3.22662593014843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.49509042716951 bayes_pls_golite062009
transcription repressor activity 2.02281452178123 bayes_pls_golite062009
protein binding 1.46569798429756 bayes_pls_golite062009
sequence-specific DNA binding 0.531186377572287 bayes_pls_golite062009
transcription factor binding 0.507261685411423 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [204-252]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APAIQMGGLQ LIPSRLPSGE FALIMPNTGS AAPPPGPFAW PGSAAGVAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [253-435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTASAALASI ANPTHLNDYT QSFRMSAFSK PVNTSVPANL PENLIHTLPG QTQLPVKNST  60
   61 SPPLSPISSI SSHCEESRAA SPTVDVMSKH SFAGVFSTPP PTSAETSFNT SGSLNLSAGS 120
  121 HDSSGCSRPL AHLQQQQVSS TSGIAKRDRE AEAESSDCSL DEPSSKKFLA GAIEKSSSAW 180
  181 RPW

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.09
Match: 2j63A
Description: No description for 2j63A was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle