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View Structure Prediction Details

Protein: CG11198-PA
Organism: Drosophila melanogaster
Length: 2482 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG11198-PA.

Description E-value Query
Range		 Subject
Range
ACACB - acetyl-CoA carboxylase beta
 2529.0 [0..26] [2476..43]

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Predicted Domain #1
Region A:
Residues: [1-681] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLITILGTLA AFLAFLLTLI FGRGQKRSKP VQSSAATSAT TATTGDSDNG NTNHNSSVIA  60
   61 ATATATTTSS KPPIAPAAPP SAVKASDKRF PKACIKKVQF SSESLRSDVD ELCDQLKDSA 120
  121 LSNLSNDNIR IACHQNNNNS SINKNQNNNS IDISISISKM SETNESNDTA AQSAEGERPS 180
  181 FLVGDEIDER AAEAGEACDE FPLKMQNDVR QNGDISERRK RLRPSMSRGT GLGQDRHQDR 240
  241 DFHIATTEEF VKRFGGTRVI NKVLIANNGI AAVKCMRSIR RWAYEMFKNE RAIRFVVMVT 300
  301 PEDLKANAEY IKMADHYVPV PGGSNNNNYA NVELIVDIAL RTQVQAVWAG WGHASENPKL 360
  361 PELLHKEGLV FLGPPERAMW ALGDKVASSI VAQTAEIPTL PWSGSDLKAQ YSGKKIKISS 420
  421 ELFARGCVTN VEQGLAAVNK IGFPVMIKAS EGGGGKGIRR VDTTEEFPGL FRQVQAEVPG 480
  481 SPIFVMKLAR GARHLEVQLL ADQYGNAISL FGRDCSIQRR HQKIIEEAPA IVAQPEVFED 540
  541 MEKAAVRLAK MVGYVSAGTV EYLYDPEGRY FFLELNPRLQ VEHPCTEMVA DVNLPAAQLQ 600
  601 IGMGIPLYRL KDIRLLYGES PWGSSVIDFE NPPNKPRPSG HVIAARITSE NPDEGFKPSS 660
  661 GTVQELNFRS SKNVWGYFSV A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 124.0
Match: 1ce8A
Description: Carbamoyl phosphate synthetase, large subunit connection domain; Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain; Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains; Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
CoA carboxylase activity 9.83581323285097 bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds 9.81059565938621 bayes_pls_golite062009
acetyl-CoA carboxylase activity 9.76633430002009 bayes_pls_golite062009
ligase activity 7.71401892529536 bayes_pls_golite062009
biotin carboxylase activity 6.9547407447638 bayes_pls_golite062009
carbamoyl-phosphate synthase activity 4.25267317906061 bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity 4.17451795830682 bayes_pls_golite062009
succinate-CoA ligase activity 3.60521632399322 bayes_pls_golite062009
CoA-ligase activity 3.23896308753196 bayes_pls_golite062009
acid-thiol ligase activity 3.04454283840859 bayes_pls_golite062009
methylcrotonoyl-CoA carboxylase activity 2.98357921316004 bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds 2.73831154716701 bayes_pls_golite062009
catalytic activity 2.5009559386228 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.20282197109991 bayes_pls_golite062009
glutathione binding 1.60917807172757 bayes_pls_golite062009
phosphoribosylaminoimidazole carboxylase activity 1.57708889650281 bayes_pls_golite062009
succinate-CoA ligase (ADP-forming) activity 1.55053478055591 bayes_pls_golite062009
transporter activity 1.29381792295125 bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor 1.11645327303429 bayes_pls_golite062009
phosphoribosylamine-glycine ligase activity 1.04915286326924 bayes_pls_golite062009
binding 0.78342355413916 bayes_pls_golite062009
propionyl-CoA carboxylase activity 0.643677287269589 bayes_pls_golite062009
hydrolase activity 0.543813086594651 bayes_pls_golite062009
succinate-CoA ligase (GDP-forming) activity 0.34559667514727 bayes_pls_golite062009
glutathione synthase activity 0.197350998474496 bayes_pls_golite062009
acid-amino acid ligase activity 0.175547438883957 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [682-814] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASGGLHEFAD SQFGHCFSWG ENRQQARENL VIALKELSIR GDFRTTVEYL ITLLETNRFL  60
   61 DNSIDTAWLD ALIAERVQSE KPDILLGVMC GSLHIADRQI TESFSSFQTS LEKGQIQAAN 120
  121 TLTNVVDVEL IND

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 147.0
Match: 2hjwA
Description: No description for 2hjwA was found.

Predicted Domain #3
Region A:
Residues: [815-884] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIRYKVQAAK SGANSYFLLM NSSFKEIEVH RLSDGGLLIS LEGASYTTYM KEEVDRYRIV  60
   61 IGNQTCVFEK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [885-956] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENDPSLLRSP SAGKLINMIV EDGAHVSKGQ AYAEIEVMKM VMTLTSQEAG TVTFVRRPGA  60
   61 VLDAGSLLGH LE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.045757
Match: 2dn8A
Description: No description for 2dn8A was found.

Predicted Domain #5
Region A:
Residues: [957-1083] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDDPSLVTKA QPFKGQFLQP ENAPVPEKLN RVHNTYKSIL ENTLAGYCLP EPFNAQRLRD  60
   61 IIEKFMQSLR DPSLPLLELQ EVIASISGRI PISVEKKIRK LMTLYERNIT SVLAQFPSQQ 120
  121 IASVIDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1084-1167] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HAATLQKRAD RDVFFLTTQS IVQLVQRYRN GIRGRMKAAV HELLRQYYDV ESQFQYGHYD  60
   61 KCVGLVREHN KDDMQTVVNT IFSH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 1c4tA
Description: Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [1168-1329] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQVAKKNLLV TLLIDHLWAN EPGLTDELAN TLSELTSLNR AEHSRVALRS RQVLIAAHQP  60
   61 AYELRHNQME SIFLSAVDMY GHDFHPENLQ RLILSETSIF DILHDFFYHS NRAVCNAALE 120
  121 VYVRRAYTSY ELTCLQHLEL SGGLPLVHFQ FLLPTAHPNR LF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1330-1476] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRMSSPDGLD QAAAESLGNS FVRTGAIAAF DSFEHFEMYS DEILDLLEDF VSPAMVNAKV  60
   61 LEAVEAADSI SDSRHSTSIN VSLSDPVTRA NAAEEAKSTE PIHIVSVAVR ETGELDDLQM 120
  121 AQIFGNYCQE HNEELFQRRI RRITFAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1477-1539] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKKRQFPKFF TFRARDKFTE DRIYRHLEPA SAFHLELNRM KTYDLEALPT ANQKMHLYLG  60
   61 KAK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1540-1654] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSKGQEVTDY RFFIRSIIRH SDLITKEASF EYLQNEGERV LLEAMDELEV AFSHPHAKRT  60
   61 DCNHIFLNFV PTVIMDPAKI EESVTKMIMR YGPRLWKLRV LQAELKMVIR QSPQS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1655-2482] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTQAVRLCIA NDSGYFLDIS MYTEQTEPET GIIKFKAYGE KQGSLHGHPI STPYMTKDFL  60
   61 QQKRFQAQSN GTTYVYDVPD MFRQMTERHW REFSKARPTV DIRTPDKILI ECKELVLEGD 120
  121 NLVEMQRLPG ENNCGMVAWR IVLATPEYPN GREIIVIAND LTYLIGSFGI KEDVLFAKAS 180
  181 QLARQLKVPR IYISVNSGAR IGLAEEVKAM FKIAWEDPEE PDKGFKYLYL STEDYAQVAN 240
  241 LNSVRAILIE DEGEQRYKIT DIIGKDDGLG VENLRYAGLI AGETSQAYEE IVTIAMVTCR 300
  301 TIGIGSYVVR LGQRVIQIDN SHIILTGYAA LNKLLGRKVY ASNNQLGGTQ IMFNNGVTHK 360
  361 TEAIDLDGVY TILDWLSYIP AYIGCDLPIV LPNDRIERPV DFMPTKSPYD PRWMLGGRVN 420
  421 PVNANDWENG FFDRDSWSEI MASWAKTVVT GRARLGGVPV GVIAVETRTV EVEMPADPAN 480
  481 LDSEAKTLQQ AGQVWYPDSS YKTAQAIKDF GREELPLIVF ANWRGFSGGM KDMYEQIVKF 540
  541 GAYIVDGLRE YKKPVLIYLP PNAELRGGAW AVLDSLINPR YMETYADPEA RGGVLEPEGI 600
  601 VEIKYKEKDL VKTIHRLDPT TIALKKELDE ANASGDKVRA AQVDEKIKAR IAVLMHVYHT 660
  661 VAVHFADLHD TPERMLEKEC ISEIVPWRDS RRWLYWRLRR LLLEDAYIKK ILRAQDNLSV 720
  721 GQAKQMLRRW LVEEKGATEA YLWDKNEEMV SWYEEQINAE SIVSRNVNSV RRDAIISTIS 780
  781 KMLEDCPDVA LDAVVGLCQG LTPVNRGVVV RTLAQMQLNE ETSNSNQG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1od2A
Description: Acetyl-coenzyme A carboxylase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle