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View Structure Prediction Details

Protein: HAND2_RAT
Organism: Rattus norvegicus
Length: 217 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HAND2_RAT.

Description E-value Query
Range
Subject
Range
gi|30231224, gi|... - gi|30231224|ref|NP_034532.2| heart and neural crest derivatives expressed transcript 2 [Mus musculus...
7.0E-46 [1..217] [1..217]
HAND2_XENLA - Heart- and neural crest derivatives-expressed protein 2 OS=Xenopus laevis GN=hand2 PE=2 SV=1
3.0E-42 [1..217] [1..210]
gi|109076191 - gi|109076191|ref|XP_001085733.1| PREDICTED: similar to heart and neural crest derivatives expressed ...
5.0E-40 [1..217] [1..186]
gi|68354996, gi|... - gi|68354996|ref|XP_694809.1| PREDICTED: similar to dHAND [Danio rerio], gi|122890476|emb|CAM13338.1|...
8.0E-40 [1..217] [1..205]
HAND2_CHICK - Heart- and neural crest derivatives-expressed protein 2 OS=Gallus gallus GN=HAND2 PE=2 SV=1
4.0E-39 [1..217] [1..216]
gi|72533403 - gi|72533403|gb|AAI01407.1| HAND2 protein [Homo sapiens]
5.0E-38 [1..217] [1..180]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH PEMSPPDYSM  60
   61 ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGGPRPVKRR GTANRKERRR TQSINSAFAE LRECIPNVPA DTKLSKIKTL RLATSYIAYL  60
   61 MDLLAKDDQN GEAEAFKAEI KKTDVKEEKR KKELNEILKS TVSSNDKKTK GRTGWPQHVW 120
  121 ALELKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.221849
Match: 1nkpA
Description: Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
promoter binding 1.56457725225443 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
transcription coactivator activity 1.39260472877067 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
structure-specific DNA binding 0.3655541712365 bayes_pls_golite062009
double-stranded DNA binding 0.29436315000437 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

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