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View Structure Prediction Details

Protein: gi|119352249
Organism: Plasmodium falciparum
Length: 875 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|119352249.

Description E-value Query
Range
Subject
Range
gi|23481012 - gi|23481012|gb|EAA17420.1| polyA binding protein-related [Plasmodium yoelii yoelii]
gi|82595449 - gi|82595449|ref|XP_725855.1| hypothetical protein [Plasmodium yoelii yoelii str. 17XNL]
513.0 [0..1] [869..1]
gi|68070939 - gi|68070939|ref|XP_677383.1| polyadenylate-binding protein [Plasmodium berghei strain ANKA]
gi|56497479 - gi|56497479|emb|CAH95361.1| polyadenylate-binding protein, putative [Plasmodium berghei]
510.0 [0..1] [875..1]
gi|70947056 - gi|70947056|ref|XP_743180.1| polyadenylate-binding protein [Plasmodium chabaudi chabaudi]
gi|56522555 - gi|56522555|emb|CAH74716.1| polyadenylate-binding protein, putative [Plasmodium chabaudi chabaudi]
392.0 [0..1] [684..1]
gi|67623121 - gi|67623121|ref|XP_667843.1| poly(a)-binding protein fabm [Cryptosporidium hominis TU502]
gi|54659004 - gi|54659004|gb|EAL37605.1| poly(a)-binding protein fabm [Cryptosporidium hominis]
370.0 [0..93] [875..1]
gi|126117428, gi... - gi|126649325|ref|XP_001388334.1| poly(a)-binding protein fabm [Cryptosporidium parvum Iowa II], gi|1...
gi|32398879 - gi|32398879|emb|CAD98589.1| putative poly(a)-binding protein fabm, possible [Cryptosporidium parvum]
368.0 [0..93] [875..1]
gi|56758360 - gi|56758360|gb|AAW27320.1| SJCHGC06322 protein [Schistosoma japonicum]
344.0 [0..102] [875..11]
gi|1082703, gi|6... - gi|693937|emb|CAA88401.1| polyadenylate binding protein II [Homo sapiens], pir||S52491 polyadenylate...
331.0 [0..382] [875..19]
gi|73976787 - gi|73976787|ref|XP_857499.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
329.0 [0..357] [874..19]
gi|76689285 - gi|76689285|ref|XP_881509.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
326.0 [0..357] [874..19]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIATGTNMMH PSFSTASLYV GDLNEDVTEA VLYEIFNTVG HVSSIRVCRD SVTRKSLGYA  60
   61 YVNYHNLADA ERALDTLNYT NIKGQPARLM WSHRDPSLRK SGTGNIFVKN LDKSIDNKAL 120
  121 FDTFSMFGNI LSCKVATDEF GKSKSYGFVH YEDEESAKEA IEKVNGVQLG SKNVYVGPFI 180
  181 KKSERATNDT 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.045757
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.24263873726102 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
poly-pyrimidine tract binding 1.04854882388951 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [191-338]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFTNLYVKNF PDSVTETHLR QLFNPYGEIT SMIVKMDNKN RKFCFINYAD AESAKNAMDN  60
   61 LNGKKITDDG QIDETYDPKK EEATASTSGA ANQTTGTDAD KTDKNDKNNK ADKNEKGDSS 120
  121 NANNNATATG ATTTDTTTTP GETTTTTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.39794
Match: 1sjrA
Description: NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.24263873726102 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
poly-pyrimidine tract binding 1.04854882388951 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [339-439]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NADSTGANNN NGLSPNTNTS NTTTGSSNNS INLNENNNTA GNNNSTNNNN NSGSSMNNAG  60
   61 SAKKDETAAS DCADTPNILY VGPHQSRARR HAILKAKFDN L

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [440-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVENKNKHQG VNLYIKNLDD GIDDIMLREL FEPFGTITSA KVMRDEKEQS KGFGFVCFAS  60
   61 QEEANKAVTE MHLKIINGKP LYVGLA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.0
Match: 2d9pA
Description: No description for 2d9pA was found.

Predicted Domain #5
Region A:
Residues: [526-617]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKREQRLSRL QQRFRMHPIR HHMNNPLNTP MQYASPQSPQ LQFSQNTLSY GRPVITAFNQ  60
   61 NNLISWRHQQ AAQQQAVHQQ AVHQQAAQQQ LN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [618-746]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNTNLRGQIN QMRLYTQNNM MNNNLNQNKP NAQLHHNQQY VPNALAQNGQ QQPNLNAAGQ  60
   61 HNAQQLQQQG NNQLLNNNMR NMNNRANRNM GNLGNMNNQK QLPLNINNKQ QNAASQANQM 120
  121 NHQAQPQGA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [747-875]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAQQKNPQQM QQVPQGNNFK FTAQARNRME LPNKNANKVN TMNNNMNVNF NNNSTLTAAA  60
   61 LASAPPSMQK QVLGENLFPL VANYHPTLAG KITGMMLEMD NSELLILLEN EEQLKKKIDE 120
  121 ALVVLQKAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.0
Match: 1g9lA
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.11788426448287 bayes_pls_golite062009
mRNA binding 4.06818972936809 bayes_pls_golite062009
nucleic acid binding 3.78909647605682 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 3.4111148675327 bayes_pls_golite062009
single-stranded RNA binding 3.03728178586535 bayes_pls_golite062009
binding 2.76167454154417 bayes_pls_golite062009
poly(A) RNA binding 2.66269581586161 bayes_pls_golite062009
poly-purine tract binding 2.60937924017999 bayes_pls_golite062009
protein binding 0.856075580719879 bayes_pls_golite062009
catalytic activity 0.287695754348243 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle