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View Structure Prediction Details

Protein: gi|119352249
Organism: Plasmodium falciparum
Length: 875 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|119352249.

Description E-value Query
Range
Subject
Range
gi|23481012 - gi|23481012|gb|EAA17420.1| polyA binding protein-related [Plasmodium yoelii yoelii]
gi|82595449 - gi|82595449|ref|XP_725855.1| hypothetical protein [Plasmodium yoelii yoelii str. 17XNL]
513.0 [0..1] [869..1]
gi|68070939 - gi|68070939|ref|XP_677383.1| polyadenylate-binding protein [Plasmodium berghei strain ANKA]
gi|56497479 - gi|56497479|emb|CAH95361.1| polyadenylate-binding protein, putative [Plasmodium berghei]
510.0 [0..1] [875..1]
gi|70947056 - gi|70947056|ref|XP_743180.1| polyadenylate-binding protein [Plasmodium chabaudi chabaudi]
gi|56522555 - gi|56522555|emb|CAH74716.1| polyadenylate-binding protein, putative [Plasmodium chabaudi chabaudi]
392.0 [0..1] [684..1]
gi|67623121 - gi|67623121|ref|XP_667843.1| poly(a)-binding protein fabm [Cryptosporidium hominis TU502]
gi|54659004 - gi|54659004|gb|EAL37605.1| poly(a)-binding protein fabm [Cryptosporidium hominis]
370.0 [0..93] [875..1]
gi|126117428, gi... - gi|126649325|ref|XP_001388334.1| poly(a)-binding protein fabm [Cryptosporidium parvum Iowa II], gi|1...
gi|32398879 - gi|32398879|emb|CAD98589.1| putative poly(a)-binding protein fabm, possible [Cryptosporidium parvum]
368.0 [0..93] [875..1]
gi|56758360 - gi|56758360|gb|AAW27320.1| SJCHGC06322 protein [Schistosoma japonicum]
344.0 [0..102] [875..11]
gi|1082703, gi|6... - gi|693937|emb|CAA88401.1| polyadenylate binding protein II [Homo sapiens], pir||S52491 polyadenylate...
331.0 [0..382] [875..19]
gi|73976787 - gi|73976787|ref|XP_857499.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
329.0 [0..357] [874..19]
gi|76689285 - gi|76689285|ref|XP_881509.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 2 ...
326.0 [0..357] [874..19]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIATGTNMMH PSFSTASLYV GDLNEDVTEA VLYEIFNTVG HVSSIRVCRD SVTRKSLGYA  60
   61 YVNYHNLADA ERALDTLNYT NIKGQPARLM WSHRDPSLRK SGTGNIFVKN LDKSIDNKAL 120
  121 FDTFSMFGNI LSCKVATDEF GKSKSYGFVH YEDEESAKEA IEKVNGVQLG SKNVYVGPFI 180
  181 KKSERATNDT 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.045757
Match: 1cvjA
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.24263873726102 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
poly-pyrimidine tract binding 1.04854882388951 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [191-338]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFTNLYVKNF PDSVTETHLR QLFNPYGEIT SMIVKMDNKN RKFCFINYAD AESAKNAMDN  60
   61 LNGKKITDDG QIDETYDPKK EEATASTSGA ANQTTGTDAD KTDKNDKNNK ADKNEKGDSS 120
  121 NANNNATATG ATTTDTTTTP GETTTTTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.39794
Match: 1sjrA
Description: NMR Structure of RRM2 from Human Polypyrimidine Tract Binding Protein Isoform 1 (PTB1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 5.15097136329571 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
mRNA binding 4.05281507540116 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
2.24263873726102 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.98418556946403 bayes_pls_golite062009
single-stranded RNA binding 1.46469774223879 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
transcription factor activity 1.07843408116687 bayes_pls_golite062009
poly-pyrimidine tract binding 1.04854882388951 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [339-439]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NADSTGANNN NGLSPNTNTS NTTTGSSNNS INLNENNNTA GNNNSTNNNN NSGSSMNNAG  60
   61 SAKKDETAAS DCADTPNILY VGPHQSRARR HAILKAKFDN L

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [440-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVENKNKHQG VNLYIKNLDD GIDDIMLREL FEPFGTITSA KVMRDEKEQS KGFGFVCFAS  60
   61 QEEANKAVTE MHLKIINGKP LYVGLA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.0
Match: 2d9pA
Description: No description for 2d9pA was found.

Predicted Domain #5
Region A:
Residues: [526-617]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKREQRLSRL QQRFRMHPIR HHMNNPLNTP MQYASPQSPQ LQFSQNTLSY GRPVITAFNQ  60
   61 NNLISWRHQQ AAQQQAVHQQ AVHQQAAQQQ LN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [618-746]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNTNLRGQIN QMRLYTQNNM MNNNLNQNKP NAQLHHNQQY VPNALAQNGQ QQPNLNAAGQ  60
   61 HNAQQLQQQG NNQLLNNNMR NMNNRANRNM GNLGNMNNQK QLPLNINNKQ QNAASQANQM 120
  121 NHQAQPQGA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [747-875]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAQQKNPQQM QQVPQGNNFK FTAQARNRME LPNKNANKVN TMNNNMNVNF NNNSTLTAAA  60
   61 LASAPPSMQK QVLGENLFPL VANYHPTLAG KITGMMLEMD NSELLILLEN EEQLKKKIDE 120
  121 ALVVLQKAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.0
Match: 1g9lA
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.11788426448287 bayes_pls_golite062009
mRNA binding 4.06818972936809 bayes_pls_golite062009
nucleic acid binding 3.78909647605682 bayes_pls_golite062009
eukaryotic initiation factor 4G binding 3.4111148675327 bayes_pls_golite062009
single-stranded RNA binding 3.03728178586535 bayes_pls_golite062009
binding 2.76167454154417 bayes_pls_golite062009
poly(A) RNA binding 2.66269581586161 bayes_pls_golite062009
poly-purine tract binding 2.60937924017999 bayes_pls_golite062009
protein binding 0.856075580719879 bayes_pls_golite062009
catalytic activity 0.287695754348243 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle