YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|123984943, gi...
Organism:	synthetic construct
Length:	763 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|123984943, gi....

Description	E-value	Query Range	Subject Range
gi\|109102275 - gi\|109102275\|ref\|XP_001086472.1\| PREDICTED: similar to hydroxyacyl dehydrogenase, subunit A isoform ...	0.0	[1..763]	[1..763]
gi\|862457, gi\|543064 - gi\|862457\|dbj\|BAA03941.1\| enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase alpha-subunit of trifu...	0.0	[1..763]	[1..763]
gi\|114576524 - gi\|114576524\|ref\|XP_515339.2\| PREDICTED: mitochondrial trifunctional protein, alpha subunit isoform ...	0.0	[1..763]	[1..763]
gi\|55730051 - gi\|55730051\|emb\|CAH91750.1\| hypothetical protein [Pongo abelii] gi\|197102182 - gi\|197102182\|ref\|NP_001126017.1\| hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase...	0.0	[1..763]	[1..763]
ECHA_RAT - Trifunctional enzyme subunit alpha, mitochondrial OS=Rattus norvegicus GN=Hadha PE=1 SV=2	0.0	[1..763]	[1..763]
gi\|54887356 - gi\|54887356\|gb\|AAH37009.1\| Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl...	0.0	[1..763]	[1..763]
gi\|74268185 - gi\|74268185\|gb\|AAI03308.1\| HADHA protein [Bos taurus]	0.0	[1..763]	[1..763]

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Predicted Domain #1

Region A:
Residues: [1-763]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVACRAIGIL SRFSAFRILR SRGYICRNFT GSSALLTRTH INYGVKGDVA VVRINSPNSK  60
   61 VNTLSKELHS EFSEVMNEIW ASDQIRSAVL ISSKPGCFIA GADINMLAAC KTLQEVTQLS 120
  121 QEAQRIVEKL EKSTKPIVAA INGSCLGGGL EVAISCQYRI ATKDRKTVLG TPEVLLGALP 180
  181 GAGGTQRLPK MVGVPAALDM MLTGRSIRAD RAKKMGLVDQ LVEPLGPGLK PPEERTIEYL 240
  241 EEVAITFAKG LADKKISPKR DKGLVEKLTA YAMTIPFVRQ QVYKKVEEKV RKQTKGLYPA 300
  301 PLKIIDVVKT GIEQGSDAGY LCESQKFGEL VMTKESKALM GLYHGQVLCK KNKFGAPQKD 360
  361 VKHLAILGAG LMGAGIAQVS VDKGLKTILK DATLTALDRG QQQVFKGLND KVKKKALTSF 420
  421 ERDSIFSNLT GQLDYQGFEK ADMVIEAVFE DLSLKHRVLK EVEAVIPDHC IFASNTSALP 480
  481 ISEIAAVSKR PEKVIGMHYF SPVDKMQLLE IITTEKTSKD TSASAVAVGL KQGKVIIVVK 540
  541 DGPGFYTTRC LAPMMSEVIR ILQEGVDPKK LDSLTTSFGF PVGAATLVDE VGVDVAKHVA 600
  601 EDLGKVFGER FGGGNPELLT QMVSKGFLGR KSGKGFYIYQ EGVKRKDLNS DMDSILASLK 660
  661 LPPKSEVSSD EDIQFRLVTR FVNEAVMCLQ EGILATPAEG DIGAVFGLGF PPCLGGPFRF 720
  721 VDLYGAQKIV DRLKKYEAAY GKQFTPCQLL ADHANSPNKK FYQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	144.0
Match:	1wdkA
Description:	fatty acid beta-oxidation multienzyme complex from Pseudomonas fragi, form I (native2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-hydroxybutyryl-CoA epimerase activity	6.21347266913168	bayes_pls_golite062009
long-chain-3-hydroxyacyl-CoA dehydrogenase activity	5.99914207874933	bayes_pls_golite062009
racemase and epimerase activity, acting on hydroxy acids and derivatives	5.93014177440654	bayes_pls_golite062009
long-chain-enoyl-CoA hydratase activity	5.38361434383109	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydratase activity	4.29069790566708	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	4.25084649365698	bayes_pls_golite062009
enoyl-CoA hydratase activity	3.92947460544831	bayes_pls_golite062009
CoA carboxylase activity	3.89913842968597	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.85567083340773	bayes_pls_golite062009
acetyl-CoA C-acyltransferase activity	3.6090947563188	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	3.4980371783229	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	3.02758902218302	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing C=C bonds	1.97586838275054	bayes_pls_golite062009
dodecenoyl-CoA delta-isomerase activity	1.80820904754223	bayes_pls_golite062009
catalytic activity	1.46154163027498	bayes_pls_golite062009
propionyl-CoA carboxylase activity	1.20853698666984	bayes_pls_golite062009
phosphogluconate dehydrogenase (decarboxylating) activity	1.10855899772836	bayes_pls_golite062009
ligase activity	0.98581896521131	bayes_pls_golite062009
transporter activity	0.793769336118517	bayes_pls_golite062009
binding	0.776704702114336	bayes_pls_golite062009
transmembrane transporter activity	0.635891484075352	bayes_pls_golite062009
retinol dehydrogenase activity	0.530688665000667	bayes_pls_golite062009
substrate-specific transporter activity	0.300373102236296	bayes_pls_golite062009
active transmembrane transporter activity	0.239024094835991	bayes_pls_golite062009
molecular transducer activity	0.201915860594054	bayes_pls_golite062009
signal transducer activity	0.201915860594054	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.165260811069909	bayes_pls_golite062009
fatty acid synthase activity	0.0962368786590111	bayes_pls_golite062009
ion transmembrane transporter activity	0.0257250793986203	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: