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View Structure Prediction Details

Protein: MYF6_MOUSE
Organism: Mus musculus
Length: 242 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MYF6_MOUSE.

Description E-value Query
Range		 Subject
Range
gi|33355711 - gi|33355711|gb|AAQ16205.1| eukaryotic myogenic factor MYF-6 [Sus scrofa]
 218.0 [0..1] [242..1]
MYF6_BOVIN - Myogenic factor 6 OS=Bos taurus GN=MYF6 PE=2 SV=1
 214.0 [0..1] [242..1]
MYF6 - myogenic factor 6 (herculin)
CCDS9019.1_1 - null
gi|109097928 - gi|109097928|ref|XP_001086944.1| PREDICTED: myogenic factor 6 (herculin) [Macaca mulatta]
gi|124000135, gi... - gi|124000135|gb|ABM87576.1| myogenic factor 6 (herculin) [synthetic construct], gi|123993145|gb|ABM8...
gi|114646062 - gi|114646062|ref|XP_001164135.1| PREDICTED: myogenic factor 6 (herculin) [Pan troglodytes]
 211.0 [0..1] [242..1]
MYF6_RAT - Myogenic factor 6 OS=Rattus norvegicus GN=Myf6 PE=2 SV=1
 210.0 [0..1] [242..1]
MYF6_CHICK - Myogenic factor 6 OS=Gallus gallus GN=MYF6 PE=2 SV=1
 185.0 [0..1] [242..1]
MYOD1_ONCMY - Myoblast determination protein 1 homolog 1 OS=Oncorhynchus mykiss GN=myod1 PE=2 SV=1
 174.0 [0..3] [241..1]

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Predicted Domain #1
Region A:
Residues: [1-87] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPQ EAGSDSSGEE  60
   61 HVLAPPGLQP PHCPGQCLIW ACKTCKR

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 35.657577
Match: PF01586.7
Description: No description for PF01586.7 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [88-154] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSAPTDRRKA ATLRERRRLK KINEAFEALK RRTVANPNQR LPKVEILRSA ISYIERLQDL  60
   61 LHRLDQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.39794
Match: 1mdyA
Description: Myod B/HLH domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
promoter binding 0.8576109846276 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [155-242] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKMQELGVDP YSYKPKQEIL EGADFLRTCS PQWPSVSDHS RGLVITAKEG GANVDASASS  60
   61 SLQRLSSIVD SISSEERKLP SVEEVVEK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.412 0.660 muscle organ development a.39.1 EF-hand
View Download 0.288 0.058 RNA polymerase II transcription factor activity, enhancer binding a.77.1 DEATH domain
View Download 0.310 0.004 RNA polymerase II transcription factor activity, enhancer binding a.109.1 Class II MHC-associated invariant chain ectoplasmic trimerization domain
View Download 0.365 N/A N/A a.39.1 EF-hand
View Download 0.283 N/A N/A a.39.1 EF-hand

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle