YRC Public Data Repository - Protein Structure Prediction

Protein:	BIRC5_MOUSE
Organism:	Mus musculus
Length:	140 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BIRC5_MOUSE.

Description	E-value	Query Range	Subject Range
BIRC5_RAT - Baculoviral IAP repeat-containing protein 5 OS=Rattus norvegicus GN=Birc5 PE=2 SV=1	164.0	[0..1]	[140..1]
gi\|67969107 - gi\|67969107\|dbj\|BAE00908.1\| unnamed protein product [Macaca fascicularis]	163.0	[0..1]	[140..1]
gi\|114690078 - gi\|114690078\|ref\|XP_529138.2\| PREDICTED: baculoviral IAP repeat-containing protein 4 [Pan troglodyte...	162.0	[0..1]	[139..149]
XIAP - X-linked inhibitor of apoptosis gi\|123979908 - gi\|123979908\|gb\|ABM81783.1\| baculoviral IAP repeat-containing 4 [synthetic construct]	162.0	[0..1]	[139..149]
gi\|60654525 - gi\|60654525\|gb\|AAX29953.1\| baculoviral IAP repeat-containing 4 [synthetic construct]	161.0	[0..1]	[139..149]
gi\|74008913 - gi\|74008913\|ref\|XP_538165.2\| PREDICTED: similar to Baculoviral IAP repeat-containing protein 4 (Inhi...	161.0	[0..1]	[139..267]

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Predicted Domain #1

Region A:
Residues: [1-140]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAPALPQIW QLYLKNYRIA TFKNWPFLED CACTPERMAE AGFIHCPTEN EPDLAQCFFC  60
   61 FKELEGWEPD DNPIEEHRKH SPGCAFLTVK KQMEELTVSE FLKLDRQRAK NKIAKETNNK 120
  121 QKEFEETAKT TRQSIEQLAA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.69897
Match:	1m4mA
Description:	Anti-apoptotic protein survivin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
microtubule binding	4.86535736353162	bayes_pls_golite062009
tubulin binding	4.84666941238345	bayes_pls_golite062009
cytoskeletal protein binding	3.62581200332375	bayes_pls_golite062009
endopeptidase inhibitor activity	3.56747355861961	bayes_pls_golite062009
peptidase inhibitor activity	3.46258520447799	bayes_pls_golite062009
caspase inhibitor activity	3.37793799691411	bayes_pls_golite062009
protein binding	2.82801305666365	bayes_pls_golite062009
binding	2.82472291325192	bayes_pls_golite062009
caspase regulator activity	2.78624473612776	bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity	2.43952820346737	bayes_pls_golite062009
enzyme inhibitor activity	1.18464294370673	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.6845701774335	bayes_pls_golite062009
small conjugating protein ligase activity	0.59597592754555	bayes_pls_golite062009
protein dimerization activity	0.204341973906209	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: