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View Structure Prediction Details

Protein: RRP4_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 329 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RRP4_SCHPO.

Description E-value Query
Range		 Subject
Range
gi|73967942 - gi|73967942|ref|XP_850770.1| PREDICTED: similar to Exosome complex exonuclease RRP4 (Ribosomal RNA p...
 259.0 [0..31] [329..1]
gi|114627214 - gi|114627214|ref|XP_001166030.1| PREDICTED: hypothetical protein isoform 4 [Pan troglodytes]
gi|208966240, gi... - gi|208966240|dbj|BAG73134.1| exosome component 2 [synthetic construct], gi|157928498|gb|ABW03545.1| ...
EXOSC2 - exosome component 2
 242.0 [0..31] [329..1]
gi|109110020 - gi|109110020|ref|XP_001106567.1| PREDICTED: exosome component 2 [Macaca mulatta]
 241.0 [0..31] [329..1]
gi|109469523, gi... - gi|62644921|ref|XP_345337.2| PREDICTED: similar to exosome component 2 [Rattus norvegicus], gi|15782...
 240.0 [0..31] [329..1]
EXOS2_BOVIN - Exosome complex component RRP4 OS=Bos taurus GN=EXOSC2 PE=2 SV=1
 239.0 [0..31] [329..1]
EXOS2_MOUSE - Exosome complex component RRP4 OS=Mus musculus GN=Exosc2 PE=1 SV=1
 237.0 [0..31] [329..1]
gi|151944013 - gi|151944013|gb|EDN62306.1| 3'-5'-exoribonuclease [Saccharomyces cerevisiae YJM789]
RRP4_YEAST - Exosome complex component RRP4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRP4 PE=1...
RRP4 - Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the n...
gi|207344689 - gi|207344689|gb|EDZ71749.1| YHR069Cp-like protein [Saccharomyces cerevisiae AWRI1631]
 233.0 [0..1] [328..4]
gi|50309037, gi|... - gi|50309037|ref|XP_454524.1| unnamed protein product [Kluyveromyces lactis], gi|49643659|emb|CAG9961...
gi|49643659 - gi|49643659|emb|CAG99611.1| KLLA0E12739p [Kluyveromyces lactis]
 230.0 [0..54] [328..133]
gi|47223594 - gi|47223594|emb|CAF99203.1| unnamed protein product [Tetraodon nigroviridis]
 228.0 [0..31] [329..1]
gi|126541110 - gi|126541110|emb|CAM45747.1| exosome component 2 [Homo sapiens]
gi|114627212 - gi|114627212|ref|XP_001165990.1| PREDICTED: hypothetical protein isoform 3 [Pan troglodytes]
 228.0 [0..31] [329..1]

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Predicted Domain #1
Region A:
Residues: [1-329] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTILKPEEF YVSSEADIVN DVSMTEMEDE IMEDEQMGLV DGEDVLEEFD KSIHQNLVTP  60
   61 GQLVTDDPQF MRGHGTYFED GGIYASVAGS VQRVNKLISV KPLRSKYVPE IGDLIIGKIA 120
  121 EVQPKRWKVD IGAKQNAVLM LSSINLPGGI QRRKLETDEL QMRSFFQEGD LLVAEVQQYF 180
  181 SDGSVSIHTR SLKYGKLRNG VFLKVPPALV VRSKSHAYAL AGGVDIILSV NGYVWVSKHN 240
  241 ENQHSSVSIT RLEEEASESI YSNENDEIDG YTRLNISRVS ICIKGLASRS LPLTQASITN 300
  301 FYESSLVFSN LQDLTVPKNM DQIAMEAMQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.221849
Match: 2nn6H
Description: No description for 2nn6H was found.

Predicted functions:

Term Confidence Notes
RNA binding 5.18414740305744 bayes_pls_golite062009
exoribonuclease activity 4.57899887224013 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 4.54136587416505 bayes_pls_golite062009
ribonuclease activity 4.53127626527286 bayes_pls_golite062009
structural constituent of ribosome 3.89236528662255 bayes_pls_golite062009
mRNA binding 3.82977088614136 bayes_pls_golite062009
nucleic acid binding 3.68444148122352 bayes_pls_golite062009
structural molecule activity 3.54418030121155 bayes_pls_golite062009
3'-5'-exoribonuclease activity 3.40736445988244 bayes_pls_golite062009
binding 2.8667878224392 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.62417180482862 bayes_pls_golite062009
3'-5' exonuclease activity 1.55351486913613 bayes_pls_golite062009
transcription regulator activity 1.43703138180882 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.42151567812515 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 1.35850109411274 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 1.35845277283398 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 1.35845277283398 bayes_pls_golite062009
1.27314120901993 bayes_pls_golite062009
exonuclease activity 1.25488463068335 bayes_pls_golite062009
DNA binding 1.20852534725468 bayes_pls_golite062009
exoribonuclease II activity 1.18248519339188 bayes_pls_golite062009
protein binding 0.934192915895039 bayes_pls_golite062009
hydrolase activity 0.704891843968224 bayes_pls_golite062009
mRNA 3'-UTR binding 0.489176583045793 bayes_pls_golite062009
transcription factor activity 0.386248501195543 bayes_pls_golite062009
ligase activity 0.346041081217685 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
catalytic activity 0.161830442565647 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.151650064901878 bayes_pls_golite062009
translation initiation factor activity 0.11625379846973 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle