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View Structure Prediction Details

Protein: PNK1_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 421 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PNK1_SCHPO.

Description E-value Query
Range
Subject
Range
PNKP_MOUSE - Bifunctional polynucleotide phosphatase/kinase OS=Mus musculus GN=Pnkp PE=1 SV=2
279.0 [0..11] [420..107]
gi|51948486, gi|... - gi|51948486|ref|NP_001004259.1| polynucleotide kinase 3' phosphatase [Rattus norvegicus], gi|5092586...
277.0 [0..11] [420..107]
gi|109125584, gi... - gi|109125584|ref|XP_001115600.1| PREDICTED: similar to polynucleotide kinase 3-phosphatase isoform 6...
267.0 [0..11] [420..107]
gi|73947014 - gi|73947014|ref|XP_541488.2| PREDICTED: similar to polynucleotide kinase 3-phosphatase isoform 1 [Ca...
266.0 [0..11] [406..107]
gi|7272098 - gi|7272098|gb|AAF44716.1|AC018766_1 Polynucleotide kinase 3'-phosphatase, partial sequence [Homo sap...
262.0 [0..11] [406..42]

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Predicted Domain #1
Region A:
Residues: [1-421]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKKRKSPP QESLTSYFEK SSKSSKKYGS QNKDSDSSST CLQQKIEIQW SITDSLYIAK  60
   61 YGKLKKTKKF IAFDLDGTLI KTKSGRVFSK DAADWTWWHP SVVPKLKALY QDNYSLVIFS 120
  121 NQNGIPRKPS AGHTFQMKIR AIFESLDLPI VLYAAILKDK FRKPLTGMWN SFLKDVNRSI 180
  181 DLSFIKYVGD AAGRPGDHNS TDLKFAENIG IKFETPEQFF LGHSFVPPNF ESFHPKNYLV 240
  241 RNSSSHPYHF KKSEHQEIVV LVGFPSSGKS TLAESQIVTQ GYERVNQDIL KTKSKCIKAA 300
  301 IEALKKEKSV VIGMYSIIST TYAISDNTNP TIESRKMWID IAQEFEIPIR CIHLQSSEEL 360
  361 ARHNNVFRYI HHNQKQLPEI AFNSFKSRFQ MPTVEEGFTN VEEVPFKCLK DYEDTWNYWY 420
  421 E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.09691
Match: 1yj5A
Description: Molecular architecture of mammalian polynucleotide kinase, a DNA repair enzyme
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 2.8454129466116 bayes_pls_golite062009
catalytic activity 1.55296860681783 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.35602953485803 bayes_pls_golite062009
ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity 1.11898265155482 bayes_pls_golite062009
polynucleotide kinase activity 1.11898265155482 bayes_pls_golite062009
polydeoxyribonucleotide kinase activity 1.11898265155482 bayes_pls_golite062009
ATP-dependent polynucleotide kinase activity 1.11898265155482 bayes_pls_golite062009
binding 0.89911057995199 bayes_pls_golite062009
nucleic acid binding 0.622587075720369 bayes_pls_golite062009
DNA binding 0.452491037562571 bayes_pls_golite062009
structure-specific DNA binding 0.35576808478553 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.317638328626539 bayes_pls_golite062009
pyrophosphatase activity 0.289666831374877 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.267902691361304 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.267204331913108 bayes_pls_golite062009
ATPase activity 0.19237422649759 bayes_pls_golite062009

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