YRC Public Data Repository - Protein Structure Prediction

Protein:	ARG56_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	885 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARG56_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|4906 - gi\|4906\|emb\|CAA45132.1\| N-acetyl-gamma-glutamyl-phosphate reductase; acetylglutamate kinase [Schizos...	660.0	[0..1]	[885..1]
gi\|49129370, gi\|... - gi\|67903566\|ref\|XP_682039.1\| hypothetical protein AN8770.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	615.0	[0..2]	[885..4]
AR56_NEUCR, ARG5... - Protein arg-6, mitochondrial OS=Neurospora crassa GN=arg-6 PE=1 SV=1, (P54898) Arg-6 protein, mitoch... ARG56_NEUCR - Protein arg-6, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM...	600.0	[0..8]	[883..2]
ARG56_NEUCR - Protein arg-6, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM... gi\|32408531, gi\|... - gi\|32408531\|ref\|XP_324747.1\| ARG-6 PROTEIN PRECURSOR [CONTAINS: N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE RE...	599.0	[0..8]	[883..2]
gi\|115386610, gi... - gi\|115386610\|ref\|XP_001209846.1\| protein arg-6, mitochondrial precursor [Aspergillus terreus NIH2624...	594.0	[0..15]	[885..5]
gi\|159122568 - gi\|159122568\|gb\|EDP47689.1\| acetylglutamate kinase, putative [Aspergillus fumigatus A1163] gi\|70984557, gi\|... - gi\|70984557\|ref\|XP_747785.1\| acetylglutamate kinase [Aspergillus fumigatus Af293], gi\|66845412\|gb\|EA...	588.0	[0..2]	[885..13]
gi\|86196380, gi\|... - gi\|86196380\|gb\|EAQ71018.1\| hypothetical protein MGCH7_ch7g425 [Magnaporthe grisea 70-15], gi\|3997044...	581.0	[0..21]	[884..16]
gi\|119173092, gi... - gi\|90297845\|gb\|EAS27476.1\| hypothetical protein CIMG_10081 [Coccidioides immitis RS], gi\|119173092\|r...	562.0	[0..25]	[885..9]
gi\|151944784 - gi\|151944784\|gb\|EDN63043.1\| N-acetyl-gamma-glutamyl-phosphate reductase [Saccharomyces cerevisiae YJ... ARG56_YEAST - Protein ARG5,6, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARG5,6 PE=... gi\|190405632 - gi\|190405632\|gb\|EDV08899.1\| N-acetyl-gamma-glutamyl-phosphate reductase [Saccharomyces cerevisiae RM... gi\|207345942 - gi\|207345942\|gb\|EDZ72596.1\| YER069Wp-like protein [Saccharomyces cerevisiae AWRI1631] ARG5,6 - Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-gl...	554.0	[0..30]	[883..34]
orf19.4788, orf1... - ARG5,6 CGDID:CAL0004595 Assembly 19, Contig19-10215 (158195, 155622) CDS, reverse complemented, tran... gi\|46445312, gi\|... - gi\|68465172\|ref\|XP_723285.1\| hypothetical protein CaO19.12252 [Candida albicans SC5314], gi\|68464793... gi\|238878658 - gi\|238878658\|gb\|EEQ42296.1\| protein ARG5,6, mitochondrial precursor [Candida albicans WO-1]	546.0	[0..59]	[885..51]

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Predicted Domain #1

Region A:
Residues: [1-352]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIELQQIVK SGLVRNGAKH CTKRSLLCSN ASVIASKRFQ GSFAPGQQQP LNPLAKPIEQ  60
   61 DRDAIIRILS SIGSRREVEQ YLRYFTSFEA QRFAIIKVGG AIITDELDTL AQSLAFLNHV 120
  121 GLYPIVVHGA GPQLNKILAS RNVEPEYSDG IRITDAETLS VARKVFLEEN AKLVDALEKL 180
  181 GTRARPITGG VFQAEYLDKE KYKYVGKIVK VNKAPIEHSI RAGTLPILTS MAETASGQLL 240
  241 NVNADITAGE LARVLKPLKV VYLNEKGGLI NGETKKKISS IYLDREYDGL MKQPWVKYGT 300
  301 KLKIKEIKEL LDTLPRTSSV AIISTKDLQK ELFTESGAGT LISRGFVINK HD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	73.221849
Match:	2btyA
Description:	Acetylglutamate kinase from Thermotoga maritima complexed with its inhibitor arginine
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetylglutamate kinase activity	4.65687695159645	bayes_pls_golite062009
acetyl-CoA:L-glutamate N-acetyltransferase activity	3.26558010592138	bayes_pls_golite062009
catalytic activity	2.83338756483354	bayes_pls_golite062009
kinase activity	2.67408574779231	bayes_pls_golite062009
phosphotransferase activity, carboxyl group as acceptor	2.65970393362911	bayes_pls_golite062009
amino acid kinase activity	2.38310367076654	bayes_pls_golite062009
transferase activity	2.34413838821786	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.29427716951794	bayes_pls_golite062009
glutamate 5-kinase activity	1.96140621254513	bayes_pls_golite062009
aspartate kinase activity	1.88373109708541	bayes_pls_golite062009
N-acetyl-gamma-glutamyl-phosphate reductase activity	1.83646634572281	bayes_pls_golite062009
binding	1.18123995031694	bayes_pls_golite062009
N-acetyltransferase activity	1.13696391910867	bayes_pls_golite062009
N-acyltransferase activity	0.92493110194105	bayes_pls_golite062009
glutamate N-acetyltransferase activity	0.39836407748845	bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity	0.201897604299108	bayes_pls_golite062009
protein binding	0.178881469836152	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.0737389599384877	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [353-498]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLDSIPDAAL ENLIIQKNSL AAPSESLKQF KDTLKDRKLR IYSDSFNESV AIVDTTDSSL  60
   61 PVLLAFGAAD NNWLNNVVDS ILTTLKADFP SLLWRLQPSA KNLEWFFSKS EGTLFANNFY 120
  121 YFWYGVKDLN KISKFIQSDK PFADAI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.522879
Match:	2re1A
Description:	No description for 2re1A was found.

Predicted Domain #3

Region A:
Residues: [499-566]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQTQSTKPPT ASSTTNNPSS SQINQKRSYS TSSLFSKNKK MNRSLFLKGG KRFFSAEAQK  60
   61 TQKPLKAV

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.99
Match:	2cvoA
Description:	Crystal structure of putative N-acetyl-gamma-glutamyl-phosphate reductase (AK071544) from rice (Oryza sativa)
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [567-885]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKPAKVVLL GARGYTGKNL IGLINTHPYL ELSHVSSREL EGTKLPGYTK KEIQYVNLST  60
   61 DDVKKLEEEG AVDAWVMALP NGVCKPYVDA LTSANGKSVI VDLSADYRFE PSWQYGLPEL 120
  121 NDREALRNSK RISNPGCYAT GSQVGLTPIL SLIDGQPSIF GVSGYSGAGT KPSPKNDLNV 180
  181 LTNNLIPYSL TDHIHEREIS YRLKQPVAFI PHVAQWFQGI TLTINVPLKK SITSRELRNL 240
  241 YQDRYNGEPL IHVQGDVPLV KDNAHKHHVS VGGFGVHSSG KRAVIVVTID NLLKGAATQA 300
  301 LQNLNLSCGY DEYAGIHLD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.221849
Match:	1vknA
Description:	Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase (TM1782) from Thermotoga maritima at 1.80 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	4.00402564572912	bayes_pls_golite062009
N-acetyl-gamma-glutamyl-phosphate reductase activity	3.56815683796128	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.69693546344908	bayes_pls_golite062009
catalytic activity	2.54843319568228	bayes_pls_golite062009
glutamate dehydrogenase [NAD(P)+] activity	2.15778057341677	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	2.00319512154556	bayes_pls_golite062009
transcription regulator activity	1.71554018493443	bayes_pls_golite062009
DNA binding	1.3548434757156	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.11682034462164	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.03017667696669	bayes_pls_golite062009
nucleic acid binding	1.00139988420709	bayes_pls_golite062009
binding	0.791812853115142	bayes_pls_golite062009
transcription factor activity	0.651793924680484	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	0.610013758225609	bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity	0.169301675015808	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	0.162625185692811	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.0992243118937675	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	0.0557896176220603	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: