YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|13361834, gi\|...
Organism:	Escherichia coli O157:H7 str. Sakai
Length:	341 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|13361834, gi|....

Description	E-value	Query Range	Subject Range
gi\|167038831, gi... - gi\|167038831\|ref\|YP_001661816.1\| periplasmic binding protein/LacI transcriptional regulator [Thermoa... gi\|242258204, gi... - gi\|242258204\|ref\|ZP_04803030.1\| transcriptional regulator, LacI family [Thermoanaerobacter sp. X513]...	363.0	[0..2]	[332..3]
gi\|20515183, gi\|... - gi\|20806727\|ref\|NP_621898.1\| transcriptional regulator [Thermoanaerobacter tengcongensis MB4], gi\|20... gi\|20806727 - gi\|20806727\|ref\|NP_621898.1\| Transcriptional regulator [Thermoanaerobacter tengcongensis MB4] gi\|254478068, gi... - gi\|254478068\|ref\|ZP_05091451.1\| Periplasmic binding proteins and sugar binding domain of the LacI fa...	362.0	[0..2]	[332..3]
gi\|76797419, gi\|... - gi\|76797419\|ref\|ZP_00779738.1\| regulatory protein, LacI:Periplasmic binding protein/LacI transcripti... gi\|241882990, gi... - gi\|241904637\|ref\|ZP_04789316.1\| transcriptional regulator, LacI family [Thermoanaerobacter brockii s...	351.0	[0..2]	[332..3]
PURR_YERPE - HTH-type transcriptional repressor PurR OS=Yersinia pestis GN=purR PE=3 SV=1 gi\|45441965, gi\|... - gi\|45441965\|ref\|NP_993504.1\| DNA-binding transcriptional repressor PurR [Yersinia pestis biovar Micr... gi\|22125842, gi\|... - gi\|22125842\|ref\|NP_669265.1\| DNA-binding transcriptional repressor PurR [Yersinia pestis KIM], gi\|21... PURR_YERPG - HTH-type transcriptional repressor PurR OS=Yersinia pestis bv. Antiqua (strain Angola) GN=purR PE=3 ... gi\|115348089, gi... - gi\|218929478\|ref\|YP_002347353.1\| DNA-binding transcriptional repressor PurR [Yersinia pestis CO92], ... PURR_YERPY - HTH-type transcriptional repressor PurR OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) G... PURR_YERPS - HTH-type transcriptional repressor PurR OS=Yersinia pseudotuberculosis serotype I (strain IP32953) G... PURR_YERPB - HTH-type transcriptional repressor PurR OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN... gi\|165913450, gi... - gi\|89103799\|ref\|ZP_01176363.1\| COG1609: Transcriptional regulators [Yersinia pestis biovar Orientali... PURR_YERPN - HTH-type transcriptional repressor PurR OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=purR PE=... gi\|229837912, gi... - gi\|229837912\|ref\|ZP_04458071.1\| DNA-binding transcriptional repressor, hypoxanthine-binding [Yersini... gi\|229701961, gi... - gi\|229895073\|ref\|ZP_04510250.1\| DNA-binding transcriptional repressor, hypoxanthine-binding [Yersini... gi\|229898475, gi... - gi\|229898475\|ref\|ZP_04513621.1\| DNA-binding transcriptional repressor, hypoxanthine-binding [Yersini... gi\|149292115, gi... - gi\|149365702\|ref\|ZP_01887737.1\| purine nucleotide synthesis repressor [Yersinia pestis CA88-4125], g... PURR_YERPP - HTH-type transcriptional repressor PurR OS=Yersinia pestis (strain Pestoides F) GN=purR PE=3 SV=1 gi\|165926499, gi... - gi\|165926499\|ref\|ZP_02222331.1\| purine nucleotide synthesis repressor [Yersinia pestis biovar Orient... PURR_YERPS - HTH-type transcriptional repressor PurR OS=Yersinia pseudotuberculosis GN=purR PE=3 SV=1 gi\|165990377, gi... - gi\|166010675\|ref\|ZP_02231573.1\| purine nucleotide synthesis repressor [Yersinia pestis biovar Antiqu... gi\|166211173, gi... - gi\|166211173\|ref\|ZP_02237208.1\| purine nucleotide synthesis repressor [Yersinia pestis biovar Antiqu... gi\|166959013, gi... - gi\|167422201\|ref\|ZP_02313954.1\| purine nucleotide synthesis repressor [Yersinia pestis biovar Orient... gi\|167425063, gi... - gi\|167425063\|ref\|ZP_02316816.1\| purine nucleotide synthesis repressor [Yersinia pestis biovar Mediae... gi\|167469396 - gi\|167469396\|ref\|ZP_02334100.1\| purine nucleotide synthesis repressor [Yersinia pestis FV-1] PURR_YERP3 - HTH-type transcriptional repressor PurR OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 3175...	351.0	[0..1]	[341..1]
gi\|238719809, gi... - gi\|77961722\|ref\|ZP_00825554.1\| COG1609: Transcriptional regulators [Yersinia mollaretii ATCC 43969],...	350.0	[0..1]	[341..1]
gi\|77959193, gi\|... - gi\|77959193\|ref\|ZP_00823215.1\| COG1609: Transcriptional regulators [Yersinia bercovieri ATCC 43970],...	350.0	[0..1]	[341..1]
gi\|77975299, gi\|... - gi\|77975299\|ref\|ZP_00830835.1\| COG1609: Transcriptional regulators [Yersinia frederiksenii ATCC 3364...	349.0	[0..1]	[341..1]
PURR_YERPA - HTH-type transcriptional repressor PurR OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=purR PE=3... gi\|167049637, gi... - gi\|167400784\|ref\|ZP_02306290.1\| purine nucleotide synthesis repressor [Yersinia pestis biovar Antiqu...	349.0	[0..1]	[341..1]

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Predicted Domain #1

Region A:
Residues: [1-341]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATIKDVAKR ANVSTTTVSH VINKTRFVAE ETRNAVWAAI KELHYSPSAV ARSLKVNHTK  60
   61 SIGLLATSSE AAYFAEIIEA VEKNCFQKGY TLILGNAWNN LEKQRAYLSM MAQKRVDGLL 120
  121 VMCSEYPEPL LAMLEEYRHI PMVVMDWGEA KADFTDAVID NAFEGGYMAG RYLIERGHRE 180
  181 IGVIPGPLER NTGAGRLAGF MKAMEEAMIK VPESWIVQGD FEPESGYRAM QQILSQPHRP 240
  241 TAVFCGGDIM AMGALCAADE MGLRVPQDVS LIGYDNVRNA RYFTPALTTI HQPKDSLGET 300
  301 AFNMLLDRIV NKREEPQSIE VHPRLIERRS VADGPFRDYR R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	95.30103
Match:	2pueA
Description:	Purine repressor (PurR), N-terminal domain; Purine repressor (PurR), C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.56046382984539	bayes_pls_golite062009
DNA binding	2.83896385348242	bayes_pls_golite062009
nucleic acid binding	2.80027597752699	bayes_pls_golite062009
transcription factor activity	2.66587775072853	bayes_pls_golite062009
binding	2.28053989162516	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.39285787026752	bayes_pls_golite062009
sequence-specific DNA binding	1.24210127552529	bayes_pls_golite062009
transporter activity	0.69447727045719	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	0.613419400163686	bayes_pls_golite062009
receptor activity	0.581432737510315	bayes_pls_golite062009
transmembrane transporter activity	0.537625088427333	bayes_pls_golite062009
transmembrane receptor activity	0.244777496593902	bayes_pls_golite062009
protein binding	0.186782087158009	bayes_pls_golite062009
G-protein coupled receptor activity	0.1760601003859	bayes_pls_golite062009
transcription factor binding	0.1642679595723	bayes_pls_golite062009
transcription cofactor activity	0.0349218665655747	bayes_pls_golite062009
substrate-specific transporter activity	0.00441561491566994	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: