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View Structure Prediction Details

Protein: Dscam-PG
Organism: Drosophila melanogaster
Length: 2032 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PG.

Description E-value Query
Range
Subject
Range
Dscam-PAO - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...
1553.0 [0..3] [2032..3]

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Predicted Domain #1
Region A:
Residues: [1-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVAQY YEADVNKEHV IRGNSAVIKC LIPSFVADFV EVVSWHTDEE 180
  181 ENYFPGAEYD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS AT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 79.221849
Match: 2v5sA
Description: No description for 2v5sA was found.

Predicted Domain #2
Region A:
Residues: [233-897]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGRLVITEPV GSVGPKLTSG DDSRTVRIRQ EDSVTLLCPA QAYPVPVYRW YKFIEGTTRK  60
   61 QAVVLNDRVK QVSGTLIIKD AVVEDSGKYL CVVNNSVGGE SVETVLTVTA PLSAKIDPPT 120
  121 QTVDFGRPAV FTCQYTGNPI KTVSWMKDGK AIGHSEPVLR IESVKKEDKG MYQCFVRNDQ 180
  181 ESAEASAELK LGGRFDPPVI RQAFQEETME PGPSVFLKCV AGGNPTPEIS WELDGKKIAN 240
  241 NDRYQVGQYV TVNGDVVSYL NITSVHANDG GLYKCIAKSK VGVAEHSAKL NVYGLPYIRQ 300
  301 MEKKAIVAGE TLIVTCPVAG YPIDSIVWER DNRALPINRK QKVFPNGTLI IENVERNSDQ 360
  361 ATYTCVAKNQ EGYSARGSLE VQVMVPPSIA PFSFGDDPVN TGENAGVQCM VQKGDVPITI 420
  421 KWTLNSRPII NGEEGITILK LSPKTSVLNI AAVEQDHRGV FKCIAENKAG SSFTTSELKV 480
  481 NVPPRWILEP TDKAFAQGSD AKVECKADGF PKPQVTWKKA VGDTPGEYKD LKKSDNIRVE 540
  541 EGTLHVDNIQ KTNEGYYLCE AINGIGSGLS AVIMISVQAP PEFTEKLRNQ TARRGEPAVL 600
  601 QCEAKGEKPI GILWNMNNMR LDPKNDNRYT IREEILSTGV MSSLSIKRTE RSDSALFTCV 660
  661 ATNAF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.522879
Match: 1e07A
Description: Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [898-1005]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSDDASINMI VQEVPEMPYA LKVLDKSGRS VQLSWAQPYD GNSPLDRYII EFKRSRASWS  60
   61 EIDRVIVPGH TTEAQVQKLS PATTYNIRIV AENAIGTSQS SEAVTIIT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.69897
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #4
Region A:
Residues: [1006-1117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEEAPSGKPQ NIKVEPVNQT TMRVTWKPPP RTEWNGEILG YYVGYKLSNT NSSYVFETIN  60
   61 FITEEGKEHN LELQNLRVYT QYSVVIQAFN KIGAGPLSEE EKQFTAEGTP SQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.045757
Match: 2edxA
Description: No description for 2edxA was found.

Predicted Domain #5
Region A:
Residues: [1118-1217]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPSDTACTTL TSQTIRVGWV SPPLESANGV IKTYKVVYAP SDEWYDETKR HYKKTASSDT  60
   61 VLHGLKKYTN YTMQVLATTA GGDGVRSVPI HCQTEPDVPE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 2dlhA
Description: No description for 2dlhA was found.

Predicted Domain #6
Region A:
Residues: [1218-1480]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APTDVKALVM GNAAILVSWR PPAQPNGIIT QYTVYSKAEG AETETKTQKV PHYQMSFEAT  60
   61 ELEKNKPYEF WVTASTTIGE GQQSKSIVAM PSDQVPAKIA SFDDTFTATF KEDAKMPCLA 120
  121 VGAPQPEITW KIKGVEFSAN DRMRVLPDGS LLIKSVNRQD AGDYSCHAEN SIAKDSITHK 180
  181 LIVLAPPQSP HVTLSATTTD ALTVKLKPHE GDTAPLHGYT LHYKPEFGEW ETSEVSVDSQ 240
  241 KHNIEGLLCG SRYQVYATGF NNI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.39794
Match: 1tdqA
Description: Structural basis for the interactions between tenascins and the C-type lectin domains from lecticans: evidence for a cross-linking role for tenascins
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 5.81747667416248 bayes_pls_golite062009
structural constituent of muscle 5.71979489668015 bayes_pls_golite062009
ankyrin binding 4.69755754047169 bayes_pls_golite062009
alpha-actinin binding 4.57951951779666 bayes_pls_golite062009
actinin binding 4.57900103206288 bayes_pls_golite062009
transmembrane receptor activity 3.79244614134061 bayes_pls_golite062009
receptor activity 3.73567137429359 bayes_pls_golite062009
cytokine binding 3.58426984827737 bayes_pls_golite062009
signal transducer activity 3.5100441341515 bayes_pls_golite062009
molecular transducer activity 3.5100441341515 bayes_pls_golite062009
cytokine receptor activity 3.25206686803048 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
growth factor binding 2.4970104838834 bayes_pls_golite062009
receptor binding 2.38673889309915 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
prolactin receptor activity 1.9556649101819 bayes_pls_golite062009
cytoskeletal protein binding 1.85720106085239 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
glycosaminoglycan binding 1.56410665522466 bayes_pls_golite062009
interleukin-6 receptor activity 1.53073516901486 bayes_pls_golite062009
interleukin-6 binding 1.53073516901486 bayes_pls_golite062009
myosin light chain kinase activity 1.49217960276915 bayes_pls_golite062009
mercury ion binding 1.46191698606762 bayes_pls_golite062009
protein kinase activity 1.42856560840953 bayes_pls_golite062009
nucleic acid binding 1.32813363771214 bayes_pls_golite062009
transcription regulator activity 1.31663344632755 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 1.27192437373177 bayes_pls_golite062009
peptide hormone binding 1.2420090521345 bayes_pls_golite062009
actin binding 1.21472460452555 bayes_pls_golite062009
DNA binding 1.2006039770643 bayes_pls_golite062009
cytokine activity 1.18680139050127 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.15899955607967 bayes_pls_golite062009
heparin binding 1.15000556789505 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.12142142875217 bayes_pls_golite062009
kinase activity 1.11027658115625 bayes_pls_golite062009
extracellular matrix structural constituent 1.1057194345531 bayes_pls_golite062009
structural molecule activity 0.94240190391222 bayes_pls_golite062009
protease binding 0.942107032692451 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
growth hormone receptor activity 0.840187286074179 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
cell surface binding 0.630081242528945 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.628488391922279 bayes_pls_golite062009
oncostatin-M receptor activity 0.628488391922279 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
collagen binding 0.593745877718282 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transcription factor activity 0.557290274937694 bayes_pls_golite062009
polysaccharide binding 0.54737137289904 bayes_pls_golite062009
cytokine receptor binding 0.47107517390107 bayes_pls_golite062009
growth factor activity 0.432629984792427 bayes_pls_golite062009
structural constituent of cytoskeleton 0.40600177052491 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
pattern binding 0.31156427047296 bayes_pls_golite062009
interleukin-7 binding 0.301052531308189 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
transcription activator activity 0.135753557343301 bayes_pls_golite062009
actin filament binding 0.135484838710405 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
transcription factor binding 0.075900818564989 bayes_pls_golite062009
interleukin-11 receptor activity 0.0423783987133706 bayes_pls_golite062009
interleukin-11 binding 0.0423783987133706 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1481-1673]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAGEASDILN TRTKGQKPKL PEKPRFIEVS SNSVSLHFKA WKDGGCPMSH FVVESKKRDQ  60
   61 IEWNQISNNV KPDNNYVVLD LEPATWYNLR ITAHNSAGFT VAEYDFATLT VTGGTIAPLD 120
  121 DGSGHGNVHT RIRLPAWMPE WLDLNFMVPL IATVVVVAVG ICVVCVALSR RRADDMRGGQ 180
  181 KDVYYDVVYN QTM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1x5kA
Description: The solution structure of the sixth fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telethonin binding 5.81747667416248 bayes_pls_golite062009
structural constituent of muscle 5.71979489668015 bayes_pls_golite062009
ankyrin binding 4.69755754047169 bayes_pls_golite062009
alpha-actinin binding 4.57951951779666 bayes_pls_golite062009
actinin binding 4.57900103206288 bayes_pls_golite062009
transmembrane receptor activity 3.79244614134061 bayes_pls_golite062009
receptor activity 3.73567137429359 bayes_pls_golite062009
cytokine binding 3.58426984827737 bayes_pls_golite062009
signal transducer activity 3.5100441341515 bayes_pls_golite062009
molecular transducer activity 3.5100441341515 bayes_pls_golite062009
cytokine receptor activity 3.25206686803048 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
binding 3.12471204223368 bayes_pls_golite062009
growth factor binding 2.4970104838834 bayes_pls_golite062009
receptor binding 2.38673889309915 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
prolactin receptor activity 1.9556649101819 bayes_pls_golite062009
cytoskeletal protein binding 1.85720106085239 bayes_pls_golite062009
interleukin-2 binding 1.67132604890013 bayes_pls_golite062009
glycosaminoglycan binding 1.56410665522466 bayes_pls_golite062009
interleukin-6 receptor activity 1.53073516901486 bayes_pls_golite062009
interleukin-6 binding 1.53073516901486 bayes_pls_golite062009
myosin light chain kinase activity 1.49217960276915 bayes_pls_golite062009
mercury ion binding 1.46191698606762 bayes_pls_golite062009
protein kinase activity 1.42856560840953 bayes_pls_golite062009
nucleic acid binding 1.32813363771214 bayes_pls_golite062009
transcription regulator activity 1.31663344632755 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 1.27192437373177 bayes_pls_golite062009
peptide hormone binding 1.2420090521345 bayes_pls_golite062009
actin binding 1.21472460452555 bayes_pls_golite062009
DNA binding 1.2006039770643 bayes_pls_golite062009
cytokine activity 1.18680139050127 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.15899955607967 bayes_pls_golite062009
heparin binding 1.15000556789505 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.12142142875217 bayes_pls_golite062009
kinase activity 1.11027658115625 bayes_pls_golite062009
extracellular matrix structural constituent 1.1057194345531 bayes_pls_golite062009
structural molecule activity 0.94240190391222 bayes_pls_golite062009
protease binding 0.942107032692451 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
growth hormone receptor activity 0.840187286074179 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
cell surface binding 0.630081242528945 bayes_pls_golite062009
leukemia inhibitory factor receptor activity 0.628488391922279 bayes_pls_golite062009
oncostatin-M receptor activity 0.628488391922279 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
collagen binding 0.593745877718282 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transcription factor activity 0.557290274937694 bayes_pls_golite062009
polysaccharide binding 0.54737137289904 bayes_pls_golite062009
cytokine receptor binding 0.47107517390107 bayes_pls_golite062009
growth factor activity 0.432629984792427 bayes_pls_golite062009
structural constituent of cytoskeleton 0.40600177052491 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
pattern binding 0.31156427047296 bayes_pls_golite062009
interleukin-7 binding 0.301052531308189 bayes_pls_golite062009
protein heterodimerization activity 0.1430595594485 bayes_pls_golite062009
transcription activator activity 0.135753557343301 bayes_pls_golite062009
actin filament binding 0.135484838710405 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
interleukin-2 receptor activity 0.115337814289139 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
transcription factor binding 0.075900818564989 bayes_pls_golite062009
interleukin-11 receptor activity 0.0423783987133706 bayes_pls_golite062009
interleukin-11 binding 0.0423783987133706 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [1674-1791]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPGATLDKRR PDLRDELGYI APPNRKLPPV PGSNYNTCDR IKRGRGGLRS NHSTWDPRRN  60
   61 PNLYEELKAP PVPMHGNHYG HAHGNAECHY RHPGMEDEIC PYATFHLLGF REEMDPTK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1792-1938]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AMNFQTFPHQ NGHAGPVPGH AGTMLPPGHP GHVHSRSGSQ SMPRANRYQR KNSQGGQSSI  60
   61 YTPAPEYDDP ANCAEEDQYR RYTRVNSQGG SLYSGPGPEY DDPANCAPEE DQYGSQYGGP 120
  121 YGQPYDHYGS RGSMGRRSIG SARNPGN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1939-2032]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSPEPPPPPP RNHDMSNSSF NDSKESNEIS EAECDRDHGP RGNYGAVKRS PQPKDQRTTE  60
   61 EMRKLIERNE TGPKQLQLQQ ANGAGFTAYD TMAV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle