YRC Public Data Repository - Protein Structure Prediction

Protein:	Dscam-PP
Organism:	Drosophila melanogaster
Length:	698 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dscam-PP.

Description	E-value	Query Range	Subject Range
Dscam-PN - The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG...	617.0	[0..1]	[698..1]

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Predicted Domain #1

Region A:
Residues: [1-138]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	97.0
Match:	2v5sA
Description:	No description for 2v5sA was found.

Predicted Domain #2

Region A:
Residues: [139-330]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHYEEDIHKA FVIRGNSAIL KCDIPSFVAD FVNVISWHSD EKENFYPGTE YDGKYLVLPS  60
   61 GELHIREVGP EDGYKSYQCR TKHRLTGETR LSATKGRLVI TEPVGFKAPS FPSVASTFTI 120
  121 QSPKKSELAL TCEAQSYPVP IFKWYKFIEG TTRKQAVVLN DRVKQVSGTL IIKDAVVEDS 180
  181 GKYLCVVNNS VG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	17.522879
Match:	2ghwB
Description:	No description for 2ghwB was found.

Predicted functions:

Term	Confidence	Notes
telethonin binding	6.64811984458494	bayes_pls_golite062009
alpha-actinin binding	5.77350124471385	bayes_pls_golite062009
actinin binding	5.69539760434923	bayes_pls_golite062009
structural constituent of muscle	4.93896503565413	bayes_pls_golite062009
antigen binding	4.06466268219034	bayes_pls_golite062009
binding	3.17641566810715	bayes_pls_golite062009
receptor activity	2.6260148704617	bayes_pls_golite062009
transmembrane receptor activity	2.26083981067854	bayes_pls_golite062009
molecular transducer activity	2.26075587783872	bayes_pls_golite062009
signal transducer activity	2.26075587783872	bayes_pls_golite062009
cytoskeletal protein binding	1.58610597245454	bayes_pls_golite062009
actin binding	1.42681407553255	bayes_pls_golite062009
peptide antigen binding	1.32632044811608	bayes_pls_golite062009
nucleic acid binding	1.32330470851159	bayes_pls_golite062009
fibroblast growth factor 1 binding	1.24415316737453	bayes_pls_golite062009
DNA binding	1.19412627500732	bayes_pls_golite062009
protein binding	1.17809977833322	bayes_pls_golite062009
transcription regulator activity	1.16252234499274	bayes_pls_golite062009
myosin light chain kinase activity	0.87238163212	bayes_pls_golite062009
receptor binding	0.838643016003073	bayes_pls_golite062009
actin filament binding	0.760856470721016	bayes_pls_golite062009
IgG binding	0.68435857661103	bayes_pls_golite062009
myosin heavy chain binding	0.66378995104464	bayes_pls_golite062009
cell adhesion molecule binding	0.63737386998612	bayes_pls_golite062009
titin binding	0.599892148302011	bayes_pls_golite062009
integrin binding	0.599569390248921	bayes_pls_golite062009
protein kinase activity	0.589015157128768	bayes_pls_golite062009
transcription factor activity	0.54549168007511	bayes_pls_golite062009
G-protein coupled receptor activity	0.51084773288725	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.5037774536831	bayes_pls_golite062009
olfactory receptor activity	0.44769371137055	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.300034766861208	bayes_pls_golite062009
protein complex binding	0.24709070548365	bayes_pls_golite062009
kinase activity	0.232190923918901	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.182775558017364	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0579247757286607	bayes_pls_golite062009
carbohydrate binding	0.0389714345254086	bayes_pls_golite062009
protein serine/threonine kinase activity	0.026512949804781	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.00722693352608417	bayes_pls_golite062009
structural molecule activity	0.00139730528977644	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [331-427]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GESVETVLTV TAPLSAKIDP PTQTVDFGRP AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV  60
   61 LRIESVKKED KGMYQCFVRN DQESAEASAE LKLGGRF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.69897
Match:	1nbqA
Description:	Junction adhesion molecule, JAM, N-terminal domain; Junction adhesion molecule, JAM, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
telethonin binding	6.64811984458494	bayes_pls_golite062009
alpha-actinin binding	5.77350124471385	bayes_pls_golite062009
actinin binding	5.69539760434923	bayes_pls_golite062009
structural constituent of muscle	4.93896503565413	bayes_pls_golite062009
antigen binding	4.06466268219034	bayes_pls_golite062009
binding	3.17641566810715	bayes_pls_golite062009
receptor activity	2.6260148704617	bayes_pls_golite062009
transmembrane receptor activity	2.26083981067854	bayes_pls_golite062009
molecular transducer activity	2.26075587783872	bayes_pls_golite062009
signal transducer activity	2.26075587783872	bayes_pls_golite062009
cytoskeletal protein binding	1.58610597245454	bayes_pls_golite062009
actin binding	1.42681407553255	bayes_pls_golite062009
peptide antigen binding	1.32632044811608	bayes_pls_golite062009
nucleic acid binding	1.32330470851159	bayes_pls_golite062009
fibroblast growth factor 1 binding	1.24415316737453	bayes_pls_golite062009
DNA binding	1.19412627500732	bayes_pls_golite062009
protein binding	1.17809977833322	bayes_pls_golite062009
transcription regulator activity	1.16252234499274	bayes_pls_golite062009
myosin light chain kinase activity	0.87238163212	bayes_pls_golite062009
receptor binding	0.838643016003073	bayes_pls_golite062009
actin filament binding	0.760856470721016	bayes_pls_golite062009
IgG binding	0.68435857661103	bayes_pls_golite062009
myosin heavy chain binding	0.66378995104464	bayes_pls_golite062009
cell adhesion molecule binding	0.63737386998612	bayes_pls_golite062009
titin binding	0.599892148302011	bayes_pls_golite062009
integrin binding	0.599569390248921	bayes_pls_golite062009
protein kinase activity	0.589015157128768	bayes_pls_golite062009
transcription factor activity	0.54549168007511	bayes_pls_golite062009
G-protein coupled receptor activity	0.51084773288725	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.5037774536831	bayes_pls_golite062009
olfactory receptor activity	0.44769371137055	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.300034766861208	bayes_pls_golite062009
protein complex binding	0.24709070548365	bayes_pls_golite062009
kinase activity	0.232190923918901	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.182775558017364	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0579247757286607	bayes_pls_golite062009
carbohydrate binding	0.0389714345254086	bayes_pls_golite062009
protein serine/threonine kinase activity	0.026512949804781	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.00722693352608417	bayes_pls_golite062009
structural molecule activity	0.00139730528977644	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [428-533]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPPVIRQAFQ EETMEPGPSV FLKCVAGGNP TPEISWELDG KKIANNDRYQ VGQYVTVNGD  60
   61 VVSYLNITSV HANDGGLYKC IAKSKVGVAE HSAKLNVYGL PYIRQM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.30103
Match:	1qz1A
Description:	Crystal Structure of the Ig 1-2-3 fragment of NCAM
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
telethonin binding	6.64811984458494	bayes_pls_golite062009
alpha-actinin binding	5.77350124471385	bayes_pls_golite062009
actinin binding	5.69539760434923	bayes_pls_golite062009
structural constituent of muscle	4.93896503565413	bayes_pls_golite062009
antigen binding	4.06466268219034	bayes_pls_golite062009
binding	3.17641566810715	bayes_pls_golite062009
receptor activity	2.6260148704617	bayes_pls_golite062009
transmembrane receptor activity	2.26083981067854	bayes_pls_golite062009
molecular transducer activity	2.26075587783872	bayes_pls_golite062009
signal transducer activity	2.26075587783872	bayes_pls_golite062009
cytoskeletal protein binding	1.58610597245454	bayes_pls_golite062009
actin binding	1.42681407553255	bayes_pls_golite062009
peptide antigen binding	1.32632044811608	bayes_pls_golite062009
nucleic acid binding	1.32330470851159	bayes_pls_golite062009
fibroblast growth factor 1 binding	1.24415316737453	bayes_pls_golite062009
DNA binding	1.19412627500732	bayes_pls_golite062009
protein binding	1.17809977833322	bayes_pls_golite062009
transcription regulator activity	1.16252234499274	bayes_pls_golite062009
myosin light chain kinase activity	0.87238163212	bayes_pls_golite062009
receptor binding	0.838643016003073	bayes_pls_golite062009
actin filament binding	0.760856470721016	bayes_pls_golite062009
IgG binding	0.68435857661103	bayes_pls_golite062009
myosin heavy chain binding	0.66378995104464	bayes_pls_golite062009
cell adhesion molecule binding	0.63737386998612	bayes_pls_golite062009
titin binding	0.599892148302011	bayes_pls_golite062009
integrin binding	0.599569390248921	bayes_pls_golite062009
protein kinase activity	0.589015157128768	bayes_pls_golite062009
transcription factor activity	0.54549168007511	bayes_pls_golite062009
G-protein coupled receptor activity	0.51084773288725	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.5037774536831	bayes_pls_golite062009
olfactory receptor activity	0.44769371137055	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.300034766861208	bayes_pls_golite062009
protein complex binding	0.24709070548365	bayes_pls_golite062009
kinase activity	0.232190923918901	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.182775558017364	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0579247757286607	bayes_pls_golite062009
carbohydrate binding	0.0389714345254086	bayes_pls_golite062009
protein serine/threonine kinase activity	0.026512949804781	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.00722693352608417	bayes_pls_golite062009
structural molecule activity	0.00139730528977644	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [534-617]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKKAIVAGET LIVTCPVAGY PIDSIVWERD NRALPINRKQ KVFPNGTLII ENVERNSDQA  60
   61 TYTCVAKNQE GYSARGSLEV QVMV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.522879
Match:	2cryA
Description:	Solution structure of the fifth ig-like domain of human kin of IRRE like 3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
telethonin binding	6.64811984458494	bayes_pls_golite062009
alpha-actinin binding	5.77350124471385	bayes_pls_golite062009
actinin binding	5.69539760434923	bayes_pls_golite062009
structural constituent of muscle	4.93896503565413	bayes_pls_golite062009
antigen binding	4.06466268219034	bayes_pls_golite062009
binding	3.17641566810715	bayes_pls_golite062009
receptor activity	2.6260148704617	bayes_pls_golite062009
transmembrane receptor activity	2.26083981067854	bayes_pls_golite062009
molecular transducer activity	2.26075587783872	bayes_pls_golite062009
signal transducer activity	2.26075587783872	bayes_pls_golite062009
cytoskeletal protein binding	1.58610597245454	bayes_pls_golite062009
actin binding	1.42681407553255	bayes_pls_golite062009
peptide antigen binding	1.32632044811608	bayes_pls_golite062009
nucleic acid binding	1.32330470851159	bayes_pls_golite062009
fibroblast growth factor 1 binding	1.24415316737453	bayes_pls_golite062009
DNA binding	1.19412627500732	bayes_pls_golite062009
protein binding	1.17809977833322	bayes_pls_golite062009
transcription regulator activity	1.16252234499274	bayes_pls_golite062009
myosin light chain kinase activity	0.87238163212	bayes_pls_golite062009
receptor binding	0.838643016003073	bayes_pls_golite062009
actin filament binding	0.760856470721016	bayes_pls_golite062009
IgG binding	0.68435857661103	bayes_pls_golite062009
myosin heavy chain binding	0.66378995104464	bayes_pls_golite062009
cell adhesion molecule binding	0.63737386998612	bayes_pls_golite062009
titin binding	0.599892148302011	bayes_pls_golite062009
integrin binding	0.599569390248921	bayes_pls_golite062009
protein kinase activity	0.589015157128768	bayes_pls_golite062009
transcription factor activity	0.54549168007511	bayes_pls_golite062009
G-protein coupled receptor activity	0.51084773288725	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.5037774536831	bayes_pls_golite062009
olfactory receptor activity	0.44769371137055	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.300034766861208	bayes_pls_golite062009
protein complex binding	0.24709070548365	bayes_pls_golite062009
kinase activity	0.232190923918901	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.182775558017364	bayes_pls_golite062009
structural constituent of cytoskeleton	0.0579247757286607	bayes_pls_golite062009
carbohydrate binding	0.0389714345254086	bayes_pls_golite062009
protein serine/threonine kinase activity	0.026512949804781	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.00722693352608417	bayes_pls_golite062009
structural molecule activity	0.00139730528977644	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [618-698]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPQIVPFAYE DLINMGDSID LFCQIQKGDR PIKVHWSFER SAGDYGFDQV QPQMRTNRIS  60
   61 EKTSMISIPS ASPAHTGRIP V

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.04
Match:	1nctA
Description:	TITIN MODULE M5, N-TERMINALLY EXTENDED, NMR
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions:

Predicted functions: