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View Structure Prediction Details

Protein: CD8B_MOUSE
Organism: Mus musculus
Length: 213 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CD8B_MOUSE.

Description E-value Query
Range
Subject
Range
gi|2765425 - gi|2765425|emb|CAA75032.1| immunoglobulin lambda heavy chain [Homo sapiens]
293.0 [0..1] [187..1]
gi|29786361 - gi|29786361|emb|CAD88275.1| anti-human CD19 monoclonal antibody 4G7 immunoglobulin gamma1 heavy chai...
281.0 [0..1] [189..1]

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Predicted Domain #1
Region A:
Residues: [1-141]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPWLWLVFS MKLAALWSSS ALIQTPSSLL VQTNHTAKMS CEVKSISKLT SIYWLRERQD  60
   61 PKDKYFEFLA SWSSSKGVLY GESVDKKRNI ILESSDSRRP FLSIMNVKPE DSDFYFCATV 120
  121 GSPKMVFGTG TKLTVVDVLP T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.30103
Match: 2atpB
Description: Crystal structure of a CD8ab heterodimer
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antigen binding 5.9176308851452 bayes_pls_golite062009
receptor activity 4.00123250685257 bayes_pls_golite062009
transmembrane receptor activity 3.81769911097805 bayes_pls_golite062009
peptide antigen binding 3.64034637674979 bayes_pls_golite062009
molecular transducer activity 3.10913345555941 bayes_pls_golite062009
signal transducer activity 3.10913345555941 bayes_pls_golite062009
binding 2.74708244886154 bayes_pls_golite062009
growth factor binding 2.28613301180608 bayes_pls_golite062009
T cell receptor binding 2.12089279430732 bayes_pls_golite062009
fibroblast growth factor 1 binding 2.0791723060792 bayes_pls_golite062009
fibroblast growth factor binding 1.66833360192732 bayes_pls_golite062009
IgG binding 1.6222936767122 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.52958974617075 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.30657787244536 bayes_pls_golite062009
fibroblast growth factor receptor activity 1.24730237107473 bayes_pls_golite062009
protein binding 1.17809977833322 bayes_pls_golite062009
immunoglobulin receptor activity 1.06402558628866 bayes_pls_golite062009
G-protein coupled receptor activity 1.02428106476324 bayes_pls_golite062009
receptor binding 0.909733688848793 bayes_pls_golite062009
protein tyrosine kinase activity 0.904613290855333 bayes_pls_golite062009
immunoglobulin binding 0.84834833214265 bayes_pls_golite062009
protein complex binding 0.83543827718565 bayes_pls_golite062009
peptide binding 0.729048089532569 bayes_pls_golite062009
coreceptor activity 0.661209696849389 bayes_pls_golite062009
cytokine binding 0.631436442105379 bayes_pls_golite062009
cytokine receptor activity 0.34165331857492 bayes_pls_golite062009
MHC class II receptor activity 0.251167772391909 bayes_pls_golite062009
olfactory receptor activity 0.20101044847022 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [142-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TAPTKKTTLK MKKKKQCPFP HPETQKGLTC SLTTLSLLVV CILLLLAFLG VAVYFYCVRR  60
   61 RARIHFMKQF HK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.154902
Match: 2h3nB
Description: No description for 2h3nB was found.

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