YRC Public Data Repository - Protein Structure Prediction

Protein:	SPF30_MOUSE
Organism:	Mus musculus
Length:	238 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPF30_MOUSE.

Description	E-value	Query Range	Subject Range
gi\|74214419 - gi\|74214419\|dbj\|BAE40445.1\| unnamed protein product [Mus musculus]	252.0	[0..1]	[238..1]
SPF30_DANRE - Survival of motor neuron-related-splicing factor 30 OS=Danio rerio GN=smndc1 PE=2 SV=1	248.0	[0..1]	[238..1]
gi\|55732755 - gi\|55732755\|emb\|CAH93075.1\| hypothetical protein [Pongo abelii] gi\|73998555 - gi\|73998555\|ref\|XP_535011.2\| PREDICTED: similar to Survival of motor neuron-related splicing factor ... SPF30_PONAB - Survival of motor neuron-related-splicing factor 30 OS=Pongo abelii GN=SMNDC1 PE=2 SV=1 gi\|149689676 - gi\|149689676\|ref\|XP_001496943.1\| PREDICTED: similar to 30kDa splicing factor; SPF 30 [Equus caballus... gi\|114632789, gi... - gi\|114632789\|ref\|XP_001142419.1\| PREDICTED: hypothetical protein LOC450730 isoform 1 [Pan troglodyte... gi\|109090545 - gi\|109090545\|ref\|XP_001085864.1\| PREDICTED: survival motor neuron domain containing 1 [Macaca mulatt... ENSCJAT00000036580 - null	244.0	[0..1]	[238..1]
SMNDC1 - survival motor neuron domain containing 1	244.0	[0..1]	[238..1]
SPF30_BOVIN - Survival of motor neuron-related-splicing factor 30 OS=Bos taurus GN=SMNDC1 PE=2 SV=1	243.0	[0..1]	[238..1]
SPF30_RAT - Survival of motor neuron-related-splicing factor 30 OS=Rattus norvegicus GN=Smndc1 PE=2 SV=1	242.0	[0..1]	[238..1]
gi\|50749781 - gi\|50749781\|ref\|XP_421753.1\| PREDICTED: similar to Survival of motor neuron-related splicing factor ...	241.0	[0..1]	[229..299]
gi\|55742438 - ref\|NP_001006857.1\| survival motor neuron domain containing 1 [Xenopus tropicalis] SPF30_XENTR - Survival of motor neuron-related-splicing factor 30 OS=Xenopus tropicalis GN=smndc1 PE=2 SV=1	233.0	[0..1]	[238..1]

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Predicted Domain #1

Region A:
Residues: [1-158]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEDLAKQLA SYKAQLQQVE AALSGNGENE DLLKLKKDLQ EVIELTKDLL STQPSETLAS  60
   61 SDSFASTQPT HSWKVGDKCM AVWSEDGQCY EAEIEEIDEE NGTAAITFAV YGNAEVTPLL 120
  121 NLKPVEEGRK AKEDSGNKPM SKKEMIAQQR EYKKKKAL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	27.69897
Match:	2hqeA
Description:	No description for 2hqeA was found.

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.08306835796752	bayes_pls_golite062009
binding	3.03932294945523	bayes_pls_golite062009
protein binding	2.81959915474598	bayes_pls_golite062009
nucleic acid binding	2.39870293911569	bayes_pls_golite062009
DNA binding	2.20609628916256	bayes_pls_golite062009
transcription repressor activity	1.54356011397295	bayes_pls_golite062009
transcription factor activity	1.48392797294737	bayes_pls_golite062009
transcription factor binding	1.47472377622426	bayes_pls_golite062009
transcription cofactor activity	1.30540808654443	bayes_pls_golite062009
chromatin binding	0.86899475761353	bayes_pls_golite062009
N-methyltransferase activity	0.53946303154276	bayes_pls_golite062009
transcription corepressor activity	0.30405575160278	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.223495463070134	bayes_pls_golite062009
transcription activator activity	0.181941750923533	bayes_pls_golite062009
sequence-specific DNA binding	0.141502107934206	bayes_pls_golite062009
histone methyltransferase activity	0.0975466265461999	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [159-238]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKAQRIKELE QEREDQKVKW QQFNNRAYSK NKKGQVKRSI FASPESVTGK VGVGTCGIAD  60
   61 KPMTQYQDTS KYNVRHLMPQ

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.367	0.102	spliceosome assembly	a.74.1	Cyclin-like
View	Download	0.224	0.012	spliceosome assembly	a.24.17	Group V grass pollen allergen
View	Download	0.232	N/A	N/A	a.74.1	Cyclin-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: