YRC Public Data Repository - Protein Structure Prediction

Protein:	AP1B1
Organism:	Homo sapiens
Length:	949 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AP1B1.

Description	E-value	Query Range	Subject Range
gi\|114668044 - gi\|114668044\|ref\|XP_001174130.1\| PREDICTED: adaptor-related protein complex 2, beta 1 subunit isofor...	0.0	[1..949]	[1..948]
AP2B1 - adaptor-related protein complex 2, beta 1 subunit gi\|149724034 - gi\|149724034\|ref\|XP_001503976.1\| PREDICTED: similar to beta-chain clathrin associated protein comple... AP2B1_RAT - AP-2 complex subunit beta OS=Rattus norvegicus GN=Ap2b1 PE=1 SV=1 gi\|73966773 - gi\|73966773\|ref\|XP_867698.1\| PREDICTED: similar to Adapter-related protein complex 2 beta 1 subunit ... gi\|114668040, gi... - gi\|114668042\|ref\|XP_001174162.1\| PREDICTED: adaptor-related protein complex 2, beta 1 subunit isofor... gi\|168277614 - gi\|168277614\|dbj\|BAG10785.1\| AP-2 complex subunit beta-1 [synthetic construct]	0.0	[1..949]	[1..937]
AP2B1_MOUSE - AP-2 complex subunit beta OS=Mus musculus GN=Ap2b1 PE=1 SV=1	0.0	[1..949]	[1..937]
gi\|73966787 - gi\|73966787\|ref\|XP_867764.1\| PREDICTED: similar to Adapter-related protein complex 2 beta 1 subunit ...	0.0	[1..949]	[1..936]
gi\|109093760, gi... - gi\|109093762\|ref\|XP_001106103.1\| PREDICTED: adaptor-related protein complex 1 beta 1 subunit isoform...	0.0	[1..949]	[1..949]

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Predicted Domain #1

Region A:
Residues: [1-589]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT  60
   61 DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE 120
  121 YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANA 180
  181 VAALSEIAES HPSSNLLDLN PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI 240
  241 CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYGTL LKKLAPPLVT LLSAEPELQY 300
  301 VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE 360
  361 YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK 420
  421 YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV 480
  481 QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV 540
  541 VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPSA FVEGGRGVV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	104.0
Match:	1gw5B
Description:	Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
clathrin binding	4.70716704570713	bayes_pls_golite062009
protein transporter activity	4.58709163830613	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
binding	2.4389817190572	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
protein binding	1.63705839411934	bayes_pls_golite062009
protein transmembrane transporter activity	1.4515576307774	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
signal sequence binding	0.57106697498903	bayes_pls_golite062009
nuclear localization sequence binding	0.342853430440159	bayes_pls_golite062009
nucleic acid binding	0.294257360897755	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009
RNA binding	0.0287526191298597	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [590-690]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HKSLPPRTAS SESAESPETA PTGAPPGEQP DVIPAQGDLL GDLLNLDLGP PVSGPPLATS  60
   61 SVQMGAVDLL GGGLDSLMGD EPEGIGGTNF VAPPTAAVPA N

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [691-949]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGAPIGSGLS DLFDLTSGVG TLSGSYVAPK AVWLPAMKAK GLEISGTFTR QVGSISMDLQ  60
   61 LTNKALQVMT DFAIQFNRNS FGLAPATPLQ VHAPLSPNQT VEISLPLSTV GSVMKMEPLN 120
  121 NLQVAVKNNI DVFYFSTLYP LHILFVEDGK MDRQMFLATW KDIPNENEAQ FQIRDCPLNA 180
  181 EAASSKLQSS NIFTVAKRNV EGQDMLYQSL KLTNGIWVLA ELRIQPGNPS CTDLELSLKC 240
  241 RAPEVSQHVY QAYETILKN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.154902
Match:	1e42A
Description:	Beta2-adaptin AP2 ear domain, N-terminal subdomain; Beta2-adaptin AP2, C-terminal subdomain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: