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View Structure Prediction Details

Protein: EIF3M
Organism: Homo sapiens
Length: 374 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EIF3M.

Description E-value Query
Range
Subject
Range
gi|109470435, gi... - gi|109470435|ref|XP_001079651.1| PREDICTED: similar to dendritic cell protein GA17 [Rattus norvegicu...
3.0E-82 [1..374] [78..451]
EIF3M_CHICK - Eukaryotic translation initiation factor 3 subunit M OS=Gallus gallus GN=EIF3M PE=2 SV=1
1.0E-77 [1..374] [1..374]
gi|62896687 - gi|62896687|dbj|BAD96284.1| dendritic cell protein variant [Homo sapiens]
1.0E-77 [1..374] [1..374]
EIF3M_PONAB - Eukaryotic translation initiation factor 3 subunit M OS=Pongo abelii GN=EIF3M PE=2 SV=1
gi|55730529 - gi|55730529|emb|CAH91986.1| hypothetical protein [Pongo abelii]
1.0E-77 [1..374] [1..374]
EIF3M_MOUSE - Eukaryotic translation initiation factor 3 subunit M OS=Mus musculus GN=Eif3m PE=1 SV=1
2.0E-77 [1..374] [1..374]
EIF3M_DANRE - Eukaryotic translation initiation factor 3 subunit M OS=Danio rerio GN=eif3m PE=2 SV=2
6.0E-77 [1..374] [1..374]
gi|114636816 - gi|114636816|ref|XP_001143260.1| PREDICTED: B5 receptor isoform 3 [Pan troglodytes]
2.0E-76 [1..374] [1..386]
EIF3M_XENTR - Eukaryotic translation initiation factor 3 subunit M OS=Xenopus tropicalis GN=eif3m PE=2 SV=1
8.0E-75 [1..373] [1..373]

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Predicted Domain #1
Region A:
Residues: [1-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVPAFIDIS EEDQAAELRA YLKSKGAEIS EENSEGGLHV DLAQIIEACD VCLKEDDKDV  60
   61 ESVMNSVVSL LLILEPDKQE ALIESLCEKL VKFREGERPS LRLQLLSNLF HGMDKNTPVR 120
  121 YTVYCSLIKV AASCGAIQYI PTELDQVRKW ISD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [154-268]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WNLTTEKKHT LLRLLYEALV DCKKSDAASK VMVELLGSYT EDNASQARVD AHRCIVRALK  60
   61 DPNAFLFDHL LTLKPVKFLE GELIHDLLTI FVSAKLASYV KFYQNNKDFI DSLGL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [269-374]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHEQNMAKMR LLTFMGMAVE NKEISFDTMQ QELQIGADDV EAFVIDAVRT KMVYCKIDQT  60
   61 QRKVVVSHST HRTFGKQQWQ QLYDTLNAWK QNLNKVKNSL LSLSDT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.69897
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.20828497061591 bayes_pls_golite062009
nucleic acid binding 3.97631536825798 bayes_pls_golite062009
DNA binding 3.93431504495991 bayes_pls_golite062009
binding 3.38086362981788 bayes_pls_golite062009
transcription factor activity 3.2482889289815 bayes_pls_golite062009
structural constituent of ribosome 2.95301685898669 bayes_pls_golite062009
structural molecule activity 2.70976099158766 bayes_pls_golite062009
sequence-specific DNA binding 1.8401324043677 bayes_pls_golite062009
transcription activator activity 1.69071209162619 bayes_pls_golite062009
transcription repressor activity 1.54960543048317 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.0361110104194 bayes_pls_golite062009
protein binding 0.776629952382685 bayes_pls_golite062009
RNA binding 0.345456982950223 bayes_pls_golite062009
transcription factor binding 0.13558561552621 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle