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View Structure Prediction Details

Protein: RARS
Organism: Homo sapiens
Length: 660 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RARS.

Description E-value Query
Range
Subject
Range
gi|109079690 - gi|109079690|ref|XP_001091294.1| PREDICTED: similar to arginyl-tRNA synthetase [Macaca mulatta]
0.0 [1..660] [1..660]
gi|62897153 - gi|62897153|dbj|BAD96517.1| arginyl-tRNA synthetase variant [Homo sapiens]
0.0 [1..660] [1..660]
gi|109487972 - gi|109487972|ref|XP_213276.3| PREDICTED: similar to Arginyl-tRNA synthetase (Arginine--tRNA ligase) ...
0.0 [1..660] [1..661]
gi|73953488 - gi|73953488|ref|XP_853102.1| PREDICTED: similar to arginyl-tRNA synthetase isoform 1 [Canis familiar...
0.0 [1..660] [1..660]
SYRC_PONPY - Arginyl-tRNA synthetase, cytoplasmic - Pongo pygmaeus (Orangutan)
SYRC_PONAB - Arginine--tRNA ligase, cytoplasmic OS=Pongo abelii GN=RARS PE=2 SV=1
0.0 [1..660] [1..660]
SYRC_MOUSE - Arginine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Rars PE=1 SV=2
0.0 [1..660] [1..660]

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Predicted Domain #1
Region A:
Residues: [1-660]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVLVSECSA RLLQQEEEIK SLTAEIDRLK NCGCLGASPN LEQLQEENLK LKYRLNILRK  60
   61 SLQAERNKPT KNMINIISRL QEVFGHAIKA AYPDLENPPL LVTPSQQAKF GDYQCNSAMG 120
  121 ISQMLKTKEQ KVNPREIAEN ITKHLPDNEC IEKVEIAGPG FINVHLRKDF VSEQLTSLLV 180
  181 NGVQLPALGE NKKVIVDFSS PNIAKEMHVG HLRSTIIGES ISRLFEFAGY DVLRLNHVGD 240
  241 WGTQFGMLIA HLQDKFPDYL TVSPPIGDLQ VFYKESKKRF DTEEEFKKRA YQCVVLLQGK 300
  301 NPDITKAWKL ICDVSRQELN KIYDALDVSL IERGESFYQD RMNDIVKEFE DRGFVQVDDG 360
  361 RKIVFVPGCS IPLTIVKSDG GYTYDTSDLA AIKQRLFEEK ADMIIYVVDN GQSVHFQTIF 420
  421 AAAQMIGWYD PKVTRVFHAG FGVVLGEDKK KFKTRSGETV RLMDLLGEGL KRSMDKLKEK 480
  481 ERDKVLTAEE LNAAQTSVAY GCIKYADLSH NRLNDYIFSF DKMLDDRGNT AAYLLYAFTR 540
  541 IRSIARLANI DEEMLQKAAR ETKILLDHEK EWKLGRCILR FPEILQKILD DLFLHTLCDY 600
  601 IYELATAFTE FYDSCYCVEK DRQTGKILKV NMWRMLLCEA VAAVMAKGFD ILGIKPVQRM 660
  661 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.39794
Match: 1bs2A
Description: Arginyl-tRNA synthetase (ArgRS); Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming aminoacyl-tRNA and related compounds 7.16276509815667 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 7.16276509815667 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 7.13957775963187 bayes_pls_golite062009
ligase activity 6.11211476973434 bayes_pls_golite062009
arginine-tRNA ligase activity 5.72854650987135 bayes_pls_golite062009
isoleucine-tRNA ligase activity 3.76808520367507 bayes_pls_golite062009
glutamate-tRNA ligase activity 2.63681738794687 bayes_pls_golite062009
methionine-tRNA ligase activity 2.56893064485672 bayes_pls_golite062009
catalytic activity 2.37674226834122 bayes_pls_golite062009
tyrosine-tRNA ligase activity 1.88984817882585 bayes_pls_golite062009
tryptophan-tRNA ligase activity 1.14187887833901 bayes_pls_golite062009
nucleic acid binding 1.03251266786448 bayes_pls_golite062009
binding 0.914435503471172 bayes_pls_golite062009
cysteine-tRNA ligase activity 0.844943947059557 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.625793556381714 bayes_pls_golite062009
nucleotidyltransferase activity 0.564359271862248 bayes_pls_golite062009
glutamine-tRNA ligase activity 0.118292082006187 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle