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View Structure Prediction Details

Protein: DYNC1LI2
Organism: Homo sapiens
Length: 492 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DYNC1LI2.

Description E-value Query
Range
Subject
Range
DC1L2_MOUSE - Cytoplasmic dynein 1 light intermediate chain 2 OS=Mus musculus GN=Dync1li2 PE=1 SV=2
0.0 [1..492] [1..492]
gi|60422784 - gi|60422784|gb|AAH89794.1| Dync1li2 protein [Rattus norvegicus]
0.0 [1..492] [1..492]
gi|76640631 - gi|76640631|ref|XP_870073.1| PREDICTED: similar to Cytoplasmic dynein 1 light intermediate chain 2 (...
0.0 [1..492] [1..492]
DC1L2_MACFA - Cytoplasmic dynein 1 light intermediate chain 2 OS=Macaca fascicularis GN=DYNC1LI2 PE=2 SV=1
0.0 [1..492] [1..492]
gi|19684163 - gi|19684163|gb|AAH25959.1| Dynein, cytoplasmic 1, light intermediate chain 2 [Homo sapiens]
0.0 [1..492] [1..492]
DC1L2_PONPY - Cytoplasmic dynein 1 light intermediate chain 2 - Pongo pygmaeus (Orangutan)
DC1L2_PONAB - Cytoplasmic dynein 1 light intermediate chain 2 OS=Pongo abelii GN=DYNC1LI2 PE=2 SV=1
0.0 [1..492] [1..492]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK LPSGKNILVF  60
   61 GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD HTRCNVWILD GDLYHKGLLK 120
  121 FAVSAESLPE TLVIFVADMS RPWTVMESLQ KWASVLREHI DKMKIPPEKM RELERKFVKD 180
  181 FQDYMEPEEG CQGSPQRRGP LTSGSDEENV ALPLG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.30103
Match: 1yzkA
Description: GppNHp bound Rab11 GTPase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
microtubule motor activity 7.68336791348661 bayes_pls_golite062009
microfilament motor activity 4.176620576177 bayes_pls_golite062009
motor activity 4.04927796049806 bayes_pls_golite062009
plus-end-directed microtubule motor activity 3.89478272344579 bayes_pls_golite062009
nucleoside-triphosphatase activity 2.95079405147356 bayes_pls_golite062009
pyrophosphatase activity 2.87427509025394 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 2.85499564954033 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.85178667290149 bayes_pls_golite062009
actin-dependent ATPase activity 2.77140616759165 bayes_pls_golite062009
tubulin binding 2.67743463093593 bayes_pls_golite062009
microtubule binding 2.59155206524122 bayes_pls_golite062009
transporter activity 2.58140740499725 bayes_pls_golite062009
cytoskeletal protein binding 2.4101693596493 bayes_pls_golite062009
transmembrane transporter activity 2.39695871109024 bayes_pls_golite062009
ATPase activity 2.39535714892224 bayes_pls_golite062009
binding 2.21604035604783 bayes_pls_golite062009
ATPase activity, coupled 2.18396165590908 bayes_pls_golite062009
actin binding 1.75397031486306 bayes_pls_golite062009
hydrolase activity 1.57549510726226 bayes_pls_golite062009
substrate-specific transporter activity 1.29730375126024 bayes_pls_golite062009
purine nucleotide binding 0.929901285538132 bayes_pls_golite062009
nucleotide binding 0.922442819194247 bayes_pls_golite062009
purine ribonucleotide binding 0.920987930180051 bayes_pls_golite062009
ribonucleotide binding 0.920926158369519 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.906554174337376 bayes_pls_golite062009
actin filament binding 0.728264616959762 bayes_pls_golite062009
active transmembrane transporter activity 0.434775387083003 bayes_pls_golite062009
ATP binding 0.41092997612902 bayes_pls_golite062009
adenyl ribonucleotide binding 0.385813421701492 bayes_pls_golite062009
adenyl nucleotide binding 0.377870145186619 bayes_pls_golite062009
ion transmembrane transporter activity 0.355466224802969 bayes_pls_golite062009
primary active transmembrane transporter activity 0.294474570607914 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.282352478532746 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.220608508617331 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.219533217661421 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.219157471322311 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleic acid binding 0.115161972169563 bayes_pls_golite062009
GTPase activity 0.105546189348878 bayes_pls_golite062009
minus-end-directed microtubule motor activity 0.068779631341469 bayes_pls_golite062009
cation transmembrane transporter activity 0.0254369227200564 bayes_pls_golite062009
structural constituent of cytoskeleton 0.0111338193708552 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [216-371]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DNVLTHNLGI PVLVVCTKCD AVSVLEKEHD YRDEHLDFIQ SHLRRFCLQY GAALIYTSVK  60
   61 EEKNLDLLYK YIVHKTYGFH FTTPALVVEK DAVFIPAGWD NEKKIAILHE NFTTVKPEDA 120
  121 YEDFIVKPPV RKLVHDKELA AEDEQVFLMK QQSLLA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [372-492]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQPATPTRAS ESPARGPSGS PRTQGRGGPA SVPSSSPGTS VKKPDPNIKN NAASEGVLAS  60
   61 FFNSLLSKKT GSPGSPGAGG VQSTAKKSGQ KTVLSNVQEE LDRMTRKPDS MVTNSSTENE 120
  121 A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle