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View Structure Prediction Details

Protein: ITCH
Organism: Homo sapiens
Length: 903 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ITCH.

Description E-value Query
Range		 Subject
Range
gi|13366088, gi|... - gi|56205868|emb|CAI17960.1| itchy E3 ubiquitin protein ligase homolog (mouse) [Homo sapiens], gi|562...
 0.0 [1..903] [1..862]
gi|94367530 - gi|94367530|ref|XP_912147.2| PREDICTED: similar to Itchy E3 ubiquitin protein ligase isoform 9 [Mus ...
 0.0 [1..903] [51..914]
gi|73991669, gi|... - gi|73991669|ref|XP_863814.1| PREDICTED: similar to itchy homolog E3 ubiquitin protein ligase isoform...
 0.0 [1..903] [1..862]
gi|109086867 - gi|109086867|ref|XP_001083053.1| PREDICTED: similar to WW domain containing E3 ubiquitin protein lig...
 0.0 [1..903] [1..927]

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Predicted Domain #1
Region A:
Residues: [1-203] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSGSQLGS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT  60
   61 NSPKWKQPLT VIVTPVSKLH FRVWSHQTLK SDVLLGTAAL DIYETLKSNN MKLEEVVVTL 120
  121 QLGGDKEPTE TIGDLSICLD GLQLESEVVT NGETTCSENG VSLCLPRLEC NSAISAHCNL 180
  181 CLPGLSDSPI SASRVAGFTG ASQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.522879
Match: 2nq3A
Description: No description for 2nq3A was found.

Predicted functions:

Term Confidence Notes
binding 2.77482286467294 bayes_pls_golite062009
calcium-dependent phospholipid binding 1.9375710282475 bayes_pls_golite062009
lipid binding 1.47484095830847 bayes_pls_golite062009
protein binding 1.33917246836907 bayes_pls_golite062009
phospholipid binding 1.01018855528345 bayes_pls_golite062009
transporter activity 0.739583681946393 bayes_pls_golite062009
neurexin binding 0.72940113160582 bayes_pls_golite062009
SNARE binding 0.568661953120771 bayes_pls_golite062009
hydrolase activity 0.501946993060588 bayes_pls_golite062009
substrate-specific transporter activity 0.203141170126034 bayes_pls_golite062009
syntaxin binding 0.0269444342534992 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [204-310] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDDGSRSKDE TRVSTNGSDD PEDAGAGENR RVSGNNSPSL SNGGFKPSRP PRPSRPPPPT  60
   61 PRRPASVNGS PSATSESDGS STGSLPPTNT NTNTSEGATS GLIIPLT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [311-405] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISGGSGPRPL NPVTQAPLPP GWEQRVDQHG RVYYVDHVEK RTTWDRPEPL PPGWERRVDN  60
   61 MGRIYYVDHF TRTTTWQRPT LESVRNYEQW QLQRS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1o6wA
Description: Splicing factor prp40
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.19063870734022 bayes_pls_golite062009
small conjugating protein ligase activity 6.90783262781184 bayes_pls_golite062009
acid-amino acid ligase activity 6.09904629433884 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 5.1950291192201 bayes_pls_golite062009
transcription activator activity 3.09768364524883 bayes_pls_golite062009
binding 2.62219069341981 bayes_pls_golite062009
transcription regulator activity 2.47616948119393 bayes_pls_golite062009
proline-rich region binding 2.34621138467934 bayes_pls_golite062009
transcription factor binding 1.94147554451393 bayes_pls_golite062009
ligase activity 1.93278509588727 bayes_pls_golite062009
histone methyltransferase activity 1.90194027965368 bayes_pls_golite062009
transcription cofactor activity 1.78278326545938 bayes_pls_golite062009
transcription coactivator activity 1.68246085059428 bayes_pls_golite062009
protein binding 1.46903005775608 bayes_pls_golite062009
lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein methyltransferase activity 1.121001087082 bayes_pls_golite062009
transcription repressor activity 0.35354889772202 bayes_pls_golite062009
catalytic activity 0.210712504691113 bayes_pls_golite062009
histone methyltransferase activity (H3-K36 specific) 0.173723075520888 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [406-518] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLQGAMQQFN QRFIYGNQDL FATSQSKEFD PLGPLPPGWE KRTDSNGRVY FVNHNTRITQ  60
   61 WEDPRSQGQL NEKPLPEGWE MRFTVDGIPY FVDHNRRTTT YIDPRTGKSA LDN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.045757
Match: 1tk7A
Description: NMR structure of WW domains (WW3-4) from Suppressor of Deltex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 7.19063870734022 bayes_pls_golite062009
small conjugating protein ligase activity 6.90783262781184 bayes_pls_golite062009
acid-amino acid ligase activity 6.09904629433884 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 5.1950291192201 bayes_pls_golite062009
transcription activator activity 3.09768364524883 bayes_pls_golite062009
binding 2.62219069341981 bayes_pls_golite062009
transcription regulator activity 2.47616948119393 bayes_pls_golite062009
proline-rich region binding 2.34621138467934 bayes_pls_golite062009
transcription factor binding 1.94147554451393 bayes_pls_golite062009
ligase activity 1.93278509588727 bayes_pls_golite062009
histone methyltransferase activity 1.90194027965368 bayes_pls_golite062009
transcription cofactor activity 1.78278326545938 bayes_pls_golite062009
transcription coactivator activity 1.68246085059428 bayes_pls_golite062009
protein binding 1.46903005775608 bayes_pls_golite062009
lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.14806422628668 bayes_pls_golite062009
protein methyltransferase activity 1.121001087082 bayes_pls_golite062009
transcription repressor activity 0.35354889772202 bayes_pls_golite062009
catalytic activity 0.210712504691113 bayes_pls_golite062009
histone methyltransferase activity (H3-K36 specific) 0.173723075520888 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [519-903] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPQIAYVRDF KAKVQYFRFW CQQLAMPQHI KITVTRKTLF EDSFQQIMSF SPQDLRRRLW  60
   61 VIFPGEEGLD YGGVAREWFF LLSHEVLNPM YCLFEYAGKD NYCLQINPAS YINPDHLKYF 120
  121 RFIGRFIAMA LFHGKFIDTG FSLPFYKRIL NKPVGLKDLE SIDPEFYNSL IWVKENNIEE 180
  181 CDLEMYFSVD KEILGEIKSH DLKPNGGNIL VTEENKEEYI RMVAEWRLSR GVEEQTQAFF 240
  241 EGFNEILPQQ YLQYFDAKEL EVLLCGMQEI DLNDWQRHAI YRHYARTSKQ IMWFWQFVKE 300
  301 IDNEKRMRLL QFVTGTCRLP VGGFADLMGS NGPQKFCIEK VGKENWLPRS HTCFNRLDLP 360
  361 PYKSYEQLKE KLLFAIEETE GFGQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 151.0
Match: 1nd7A
Description: Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 11.7414753295465 bayes_pls_golite062009
small conjugating protein ligase activity 11.4871643691645 bayes_pls_golite062009
acid-amino acid ligase activity 10.4323719338452 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 9.13168684685485 bayes_pls_golite062009
ligase activity 5.34807997732606 bayes_pls_golite062009
proline-rich region binding 2.8338032434061 bayes_pls_golite062009
sodium channel inhibitor activity 2.81182200437095 bayes_pls_golite062009
binding 2.51893471705946 bayes_pls_golite062009
ion channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
channel inhibitor activity 2.14402963004533 bayes_pls_golite062009
transcription regulator activity 1.53041428769512 bayes_pls_golite062009
nucleic acid binding 1.45373137371678 bayes_pls_golite062009
phosphothreonine binding 1.40065636224804 bayes_pls_golite062009
phosphoserine binding 1.40065636224804 bayes_pls_golite062009
protein binding 1.39373180706125 bayes_pls_golite062009
DNA binding 1.32990029553036 bayes_pls_golite062009
catalytic activity 1.15152367676155 bayes_pls_golite062009
receptor binding 1.0452382475744 bayes_pls_golite062009
transcription activator activity 0.844956469266212 bayes_pls_golite062009
ubiquitin binding 0.60123113960943 bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity 0.598436219078807 bayes_pls_golite062009
transcription factor binding 0.558655949211634 bayes_pls_golite062009
small conjugating protein binding 0.33937847204197 bayes_pls_golite062009
sodium channel regulator activity 0.325435827772996 bayes_pls_golite062009
nuclear hormone receptor binding 0.204781102077891 bayes_pls_golite062009
channel regulator activity 0.072778668515899 bayes_pls_golite062009
0.051942165438844 bayes_pls_golite062009
hormone receptor binding 0.02403431201602 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle