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Protein Overview: ITCH

General Information:
Name(s) found: ITCH [HGNC (HUGO)]
Description(s) found:
Found 28 descriptions.
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  • itchy E3 ubiquitin protein ligase homolog (mouse) [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 903 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSGSQLGS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT  60
   61 NSPKWKQPLT VIVTPVSKLH FRVWSHQTLK SDVLLGTAAL DIYETLKSNN MKLEEVVVTL 120
  121 QLGGDKEPTE TIGDLSICLD GLQLESEVVT NGETTCSENG VSLCLPRLEC NSAISAHCNL 180
  181 CLPGLSDSPI SASRVAGFTG ASQNDDGSRS KDETRVSTNG SDDPEDAGAG ENRRVSGNNS 240
  241 PSLSNGGFKP SRPPRPSRPP PPTPRRPASV NGSPSATSES DGSSTGSLPP TNTNTNTSEG 300
  301 ATSGLIIPLT ISGGSGPRPL NPVTQAPLPP GWEQRVDQHG RVYYVDHVEK RTTWDRPEPL 360
  361 PPGWERRVDN MGRIYYVDHF TRTTTWQRPT LESVRNYEQW QLQRSQLQGA MQQFNQRFIY 420
  421 GNQDLFATSQ SKEFDPLGPL PPGWEKRTDS NGRVYFVNHN TRITQWEDPR SQGQLNEKPL 480
  481 PEGWEMRFTV DGIPYFVDHN RRTTTYIDPR TGKSALDNGP QIAYVRDFKA KVQYFRFWCQ 540
  541 QLAMPQHIKI TVTRKTLFED SFQQIMSFSP QDLRRRLWVI FPGEEGLDYG GVAREWFFLL 600
  601 SHEVLNPMYC LFEYAGKDNY CLQINPASYI NPDHLKYFRF IGRFIAMALF HGKFIDTGFS 660
  661 LPFYKRILNK PVGLKDLESI DPEFYNSLIW VKENNIEECD LEMYFSVDKE ILGEIKSHDL 720
  721 KPNGGNILVT EENKEEYIRM VAEWRLSRGV EEQTQAFFEG FNEILPQQYL QYFDAKELEV 780
  781 LLCGMQEIDL NDWQRHAIYR HYARTSKQIM WFWQFVKEID NEKRMRLLQF VTGTCRLPVG 840
  841 GFADLMGSNG PQKFCIEKVG KENWLPRSHT CFNRLDLPPY KSYEQLKEKL LFAIEETEGF 900
  901 GQE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..203] PSI-BLAST 19.522879 No description for 2nq3A was found.
    2 View Details [204..310] deduced N/A No confident structure predictions are available.
    3 View Details [311..405] PSI-BLAST 5.522879 Splicing factor prp40
    4 View Details [406..518] PSI-BLAST 9.045757 NMR structure of WW domains (WW3-4) from Suppressor of Deltex
    5 View Details [519..903] PSI-BLAST 151.0 Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.77482286467294 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  1.9375710282475 bayes_pls_golite062009
  • lipid binding
    		•  1.47484095830847 bayes_pls_golite062009
  • protein binding
    		•  1.33917246836907 bayes_pls_golite062009
  • phospholipid binding
    		•  1.01018855528345 bayes_pls_golite062009
  • transporter activity
    		•  0.739583681946393 bayes_pls_golite062009
  • neurexin binding
    		•  0.72940113160582 bayes_pls_golite062009
  • SNARE binding
    		•  0.568661953120771 bayes_pls_golite062009
  • hydrolase activity
    		•  0.501946993060588 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.203141170126034 bayes_pls_golite062009
  • syntaxin binding
    		•  0.0269444342534992 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.19063870734022 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.90783262781184 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.09904629433884 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.1950291192201 bayes_pls_golite062009
  • transcription activator activity
    		•  3.09768364524883 bayes_pls_golite062009
  • binding
    		•  2.62219069341981 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.47616948119393 bayes_pls_golite062009
  • proline-rich region binding
    		•  2.34621138467934 bayes_pls_golite062009
  • transcription factor binding
    		•  1.94147554451393 bayes_pls_golite062009
  • ligase activity
    		•  1.93278509588727 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.90194027965368 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.78278326545938 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.68246085059428 bayes_pls_golite062009
  • protein binding
    		•  1.46903005775608 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.121001087082 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.35354889772202 bayes_pls_golite062009
  • catalytic activity
    		•  0.210712504691113 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K36 specific)
    		•  0.173723075520888 bayes_pls_golite062009
    4
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.19063870734022 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.90783262781184 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.09904629433884 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.1950291192201 bayes_pls_golite062009
  • transcription activator activity
    		•  3.09768364524883 bayes_pls_golite062009
  • binding
    		•  2.62219069341981 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.47616948119393 bayes_pls_golite062009
  • proline-rich region binding
    		•  2.34621138467934 bayes_pls_golite062009
  • transcription factor binding
    		•  1.94147554451393 bayes_pls_golite062009
  • ligase activity
    		•  1.93278509588727 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.90194027965368 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.78278326545938 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.68246085059428 bayes_pls_golite062009
  • protein binding
    		•  1.46903005775608 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  1.14806422628668 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  1.121001087082 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.35354889772202 bayes_pls_golite062009
  • catalytic activity
    		•  0.210712504691113 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K36 specific)
    		•  0.173723075520888 bayes_pls_golite062009
    5
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.7414753295465 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.4871643691645 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.4323719338452 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  9.13168684685485 bayes_pls_golite062009
  • ligase activity
    		•  5.34807997732606 bayes_pls_golite062009
  • proline-rich region binding
    		•  2.8338032434061 bayes_pls_golite062009
  • sodium channel inhibitor activity
    		•  2.81182200437095 bayes_pls_golite062009
  • binding
    		•  2.51893471705946 bayes_pls_golite062009
  • ion channel inhibitor activity
    		•  2.14402963004533 bayes_pls_golite062009
  • channel inhibitor activity
    		•  2.14402963004533 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.53041428769512 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.45373137371678 bayes_pls_golite062009
  • phosphothreonine binding
    		•  1.40065636224804 bayes_pls_golite062009
  • phosphoserine binding
    		•  1.40065636224804 bayes_pls_golite062009
  • protein binding
    		•  1.39373180706125 bayes_pls_golite062009
  • DNA binding
    		•  1.32990029553036 bayes_pls_golite062009
  • catalytic activity
    		•  1.15152367676155 bayes_pls_golite062009
  • receptor binding
    		•  1.0452382475744 bayes_pls_golite062009
  • transcription activator activity
    		•  0.844956469266212 bayes_pls_golite062009
  • ubiquitin binding
    		•  0.60123113960943 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  0.598436219078807 bayes_pls_golite062009
  • transcription factor binding
    		•  0.558655949211634 bayes_pls_golite062009
  • small conjugating protein binding
    		•  0.33937847204197 bayes_pls_golite062009
  • sodium channel regulator activity
    		•  0.325435827772996 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.204781102077891 bayes_pls_golite062009
  • channel regulator activity
    		•  0.072778668515899 bayes_pls_golite062009
    		• 0.051942165438844 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.02403431201602 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle