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View Structure Prediction Details

Protein: gi|18450371, gi|...
Organism: Homo sapiens
Length: 793 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|18450371, gi|....

Description E-value Query
Range		 Subject
Range
gi|32067 - gi|32067|emb|CAA37447.1| tyrosine phosphatase precursor [Homo sapiens]
 0.0 [1..793] [1..793]
gi|109092682 - gi|109092682|ref|XP_001114682.1| PREDICTED: similar to protein tyrosine phosphatase, receptor type, ...
 0.0 [1..793] [1..793]
gi|21912410, gi|... - gi|83405583|gb|AAI10684.1| Ptpra protein [Mus musculus], gi|62635488|gb|AAX90613.1| Ptpra [Mus muscu...
 0.0 [1..793] [1..793]
gi|194672537, gi... - gi|76672197|ref|XP_594101.2| PREDICTED: similar to protein tyrosine phosphatase, receptor type, A is...
 0.0 [1..793] [1..792]
gi|51859138, gi|... - gi|62645775|ref|XP_346676.2| PREDICTED: hypothetical protein XP_346675 [Rattus norvegicus], gi|51859...
 0.0 [1..793] [1..796]
gi|114680587, gi... - gi|114680595|ref|XP_001158634.1| PREDICTED: protein tyrosine phosphatase, receptor type, A isoform 1...
 0.0 [1..793] [1..793]

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Predicted Domain #1
Region A:
Residues: [1-199] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS NPTSSLTSLS  60
   61 VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT ISPNGTWLPD NQFTDARTEP 120
  121 WEGNSSTAAT TPETFPPSDE TPIIAVMVAL SSLLVIVFII IVLYMLRFKK YKQAGSHSNS 180
  181 FRLSNGRTED VEPQSVPLL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.17
Match: 2j63A
Description: No description for 2j63A was found.

Predicted Domain #2
Region A:
Residues: [200-512] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARSPSTNRKY PPLPVDKLEE EINRRMADDN KLFREEFNAL PACPIQATCE AASKEENKEK  60
   61 NRYVNILPYD HSRVHLTPVE GVPDSDYINA SFINGYQEKN KFIAAQGPKE ETVNDFWRMI 120
  121 WEQNTATIVM VTNLKERKEC KCAQYWPDQG CWTYGNIRVS VEDVTVLVDY TVRKFCIQQV 180
  181 GDMTNRKPQR LITQFHFTSW PDFGVPFTPI GMLKFLKKVK ACNPQYAGAI VVHCSAGVGR 240
  241 TGTFVVIDAM LDMMHTERKV DVYGFVSRIR AQRCQMVQTD MQYVFIYQAL LEHYLYGDTE 300
  301 LEVTSLETHL QKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.30103
Match: 1yfoA
Description: Tyrosine phosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoprotein phosphatase activity 7.30669036331612 bayes_pls_golite062009
phosphatase activity 7.03758345564381 bayes_pls_golite062009
phosphoric ester hydrolase activity 6.82821455971597 bayes_pls_golite062009
protein tyrosine phosphatase activity 6.07449851643404 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 5.83769298632658 bayes_pls_golite062009
receptor tyrosine kinase binding 5.39791540743613 bayes_pls_golite062009
transmembrane receptor protein phosphatase activity 4.57221148210263 bayes_pls_golite062009
transmembrane receptor protein tyrosine phosphatase activity 4.57221148210263 bayes_pls_golite062009
transmembrane receptor activity 3.4815731203374 bayes_pls_golite062009
receptor activity 3.2014960162856 bayes_pls_golite062009
hydrolase activity 2.90276529968189 bayes_pls_golite062009
protein tyrosine/serine/threonine phosphatase activity 2.77531895423367 bayes_pls_golite062009
insulin receptor binding 2.63442848340688 bayes_pls_golite062009
protein serine/threonine phosphatase activity 2.49496709551693 bayes_pls_golite062009
signal transducer activity 2.27602678801224 bayes_pls_golite062009
molecular transducer activity 2.27602678801224 bayes_pls_golite062009
protein binding 2.12487185456363 bayes_pls_golite062009
binding 2.06015698112379 bayes_pls_golite062009
non-membrane spanning protein tyrosine phosphatase activity 2.04600549829086 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.56455764981613 bayes_pls_golite062009
kinase activity 1.54798529194457 bayes_pls_golite062009
cell adhesion molecule binding 1.53727496158735 bayes_pls_golite062009
nucleic acid binding 1.38282868576714 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.36326098454926 bayes_pls_golite062009
protein kinase activity 1.3466747511896 bayes_pls_golite062009
DNA binding 1.31084450519924 bayes_pls_golite062009
transporter activity 1.21792561830727 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 1.1200449509328 bayes_pls_golite062009
catalytic activity 1.06283028154109 bayes_pls_golite062009
transferase activity 1.05480035577492 bayes_pls_golite062009
lipid phosphatase activity 1.05085928819585 bayes_pls_golite062009
beta-catenin binding 1.02079992407668 bayes_pls_golite062009
transmembrane transporter activity 1.00030784939308 bayes_pls_golite062009
kinase binding 0.95875467592478 bayes_pls_golite062009
delta-catenin binding 0.89195134506409 bayes_pls_golite062009
protein kinase binding 0.83725631602383 bayes_pls_golite062009
substrate-specific transporter activity 0.73846553033987 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.49044345981587 bayes_pls_golite062009
phospholipase binding 0.43589778800599 bayes_pls_golite062009
insulin receptor substrate binding 0.366350463194201 bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity 0.28805451968625 bayes_pls_golite062009
peptide hormone receptor binding 0.272080084933271 bayes_pls_golite062009
gated channel activity 0.217548650508289 bayes_pls_golite062009
ion transmembrane transporter activity 0.200180223985633 bayes_pls_golite062009
enzyme binding 0.150910330021054 bayes_pls_golite062009
receptor binding 0.0137204844761347 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [513-793] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNKIPGTSNN GLEEEFKKLT SIKIQNDKMR TGNLPANMKK NRVLQIIPYE FNRVIIPVKR  60
   61 GEENTDYVNA SFIDGYRQKD SYIASQGPLL HTIEDFWRMI WEWKSCSIVM LTELEERGQE 120
  121 KCAQYWPSDG LVSYGDITVE LKKEEECESY TVRDLLVTNT RENKSRQIRQ FHFHGWPEVG 180
  181 IPSDGKGMIS IIAAVQKQQQ QSGNHPITVH CSAGAGRTGT FCALSTVLER VKAEGILDVF 240
  241 QTVKSLRLQR PHMVQTLEQY EFCYKVVQEY IDAFSDYANF K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.69897
Match: 1p15A
Description: Crystal structure of the D2 domain of RPTPa
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoprotein phosphatase activity 7.30669036331612 bayes_pls_golite062009
phosphatase activity 7.03758345564381 bayes_pls_golite062009
phosphoric ester hydrolase activity 6.82821455971597 bayes_pls_golite062009
protein tyrosine phosphatase activity 6.07449851643404 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 5.83769298632658 bayes_pls_golite062009
receptor tyrosine kinase binding 5.39791540743613 bayes_pls_golite062009
transmembrane receptor protein phosphatase activity 4.57221148210263 bayes_pls_golite062009
transmembrane receptor protein tyrosine phosphatase activity 4.57221148210263 bayes_pls_golite062009
transmembrane receptor activity 3.4815731203374 bayes_pls_golite062009
receptor activity 3.2014960162856 bayes_pls_golite062009
hydrolase activity 2.90276529968189 bayes_pls_golite062009
protein tyrosine/serine/threonine phosphatase activity 2.77531895423367 bayes_pls_golite062009
insulin receptor binding 2.63442848340688 bayes_pls_golite062009
protein serine/threonine phosphatase activity 2.49496709551693 bayes_pls_golite062009
signal transducer activity 2.27602678801224 bayes_pls_golite062009
molecular transducer activity 2.27602678801224 bayes_pls_golite062009
protein binding 2.12487185456363 bayes_pls_golite062009
binding 2.06015698112379 bayes_pls_golite062009
non-membrane spanning protein tyrosine phosphatase activity 2.04600549829086 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.56455764981613 bayes_pls_golite062009
kinase activity 1.54798529194457 bayes_pls_golite062009
cell adhesion molecule binding 1.53727496158735 bayes_pls_golite062009
nucleic acid binding 1.38282868576714 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.36326098454926 bayes_pls_golite062009
protein kinase activity 1.3466747511896 bayes_pls_golite062009
DNA binding 1.31084450519924 bayes_pls_golite062009
transporter activity 1.21792561830727 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 1.1200449509328 bayes_pls_golite062009
catalytic activity 1.06283028154109 bayes_pls_golite062009
transferase activity 1.05480035577492 bayes_pls_golite062009
lipid phosphatase activity 1.05085928819585 bayes_pls_golite062009
beta-catenin binding 1.02079992407668 bayes_pls_golite062009
transmembrane transporter activity 1.00030784939308 bayes_pls_golite062009
kinase binding 0.95875467592478 bayes_pls_golite062009
delta-catenin binding 0.89195134506409 bayes_pls_golite062009
protein kinase binding 0.83725631602383 bayes_pls_golite062009
substrate-specific transporter activity 0.73846553033987 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.49044345981587 bayes_pls_golite062009
phospholipase binding 0.43589778800599 bayes_pls_golite062009
insulin receptor substrate binding 0.366350463194201 bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity 0.28805451968625 bayes_pls_golite062009
peptide hormone receptor binding 0.272080084933271 bayes_pls_golite062009
gated channel activity 0.217548650508289 bayes_pls_golite062009
ion transmembrane transporter activity 0.200180223985633 bayes_pls_golite062009
enzyme binding 0.150910330021054 bayes_pls_golite062009
receptor binding 0.0137204844761347 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle