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View Structure Prediction Details

Protein: CE40251
Organism: Caenorhabditis elegans
Length: 402 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE40251.

Description E-value Query
Range		 Subject
Range
gi|50084974, gi|... - gi|50084974|ref|YP_046484.1| short chain dehydrogenase [Acinetobacter sp. ADP1], gi|49530950|emb|CAG...
 286.0 [0..3] [398..150]

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Predicted Domain #1
Region A:
Residues: [1-126] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMYYGMSKAA LDQFTRSTAI TLIQHGVRVN SVSPGVVYTG IGEAMGFPPG AFEKTMKFYE  60
   61 SHKECVPCGH MAQPVEIAQV IAFLADRTMS SYIIGQSIIA DGGSSLVMGM QAHDIIEILK 120
  121 HSMARF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.522879
Match: 2z5lA
Description: No description for 2z5lA was found.

Predicted Domain #2
Region A:
Residues: [127-402] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGKVALVTGS SNGIGRAAAL LFAQQGAKVT ITGRNAERLE ETRQAILKSG VPAENVLAIA  60
   61 ADLATDQGQT DLINGTLQKF GRLDILVNNA GAAVNDPQGR MGIDQQIEDF DKTFQINMRS 120
  121 VVTLVQKAKE HLIKTKGEII NVSSIGGGPH AQPDMMYYGM SKAALDQFTR STAITLIQHG 180
  181 VRVNSVSPGG VYTGFGEAMG FPPGALEKIM KYFESHKECV PCGHMAQPIE IAQVIAFLAD 240
  241 RTMSSYIIGQ SIIADGGSSL LMGMQAHDMM EILKQP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.522879
Match: 1xkqA
Description: Crystal Structure of Short-Chain Dehydrogenase/Reductase of unknown Function from Caenorhabditis Elegans with Cofactor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
retinol dehydrogenase activity 4.1750549780559 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity 3.06391460989761 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 3.02758902218302 bayes_pls_golite062009
ethanol binding 3.01624801418439 bayes_pls_golite062009
retinol binding 2.89007863838685 bayes_pls_golite062009
L-iditol 2-dehydrogenase activity 2.85461175493562 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 2.344389379767 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 2.03039843216597 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
steroid dehydrogenase activity 1.75109362865449 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.55012034958204 bayes_pls_golite062009
L-arabinitol 2-dehydrogenase activity 1.54130379492877 bayes_pls_golite062009
alcohol binding 1.51091775360793 bayes_pls_golite062009
all-trans retinal binding 1.47861183836779 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 1.27032644348698 bayes_pls_golite062009
fatty acid synthase activity 1.23679054027553 bayes_pls_golite062009
NADPH:quinone reductase activity 1.19042587095474 bayes_pls_golite062009
sorbose reductase activity 1.06293597394863 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 1.01627645289834 bayes_pls_golite062009
binding 0.982999356179965 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 0.729242797855749 bayes_pls_golite062009
retinal dehydrogenase activity 0.69372321031969 bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity 0.604742541607263 bayes_pls_golite062009
3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity 0.583772223704381 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.576163737662951 bayes_pls_golite062009
testosterone 17-beta-dehydrogenase activity 0.532187027260366 bayes_pls_golite062009
DNA binding 0.525227236870065 bayes_pls_golite062009
nucleic acid binding 0.459537641913493 bayes_pls_golite062009
NAD or NADH binding 0.44922383360529 bayes_pls_golite062009
enoyl-CoA hydratase activity 0.439912268968251 bayes_pls_golite062009
coenzyme binding 0.35922330382799 bayes_pls_golite062009
transcription regulator activity 0.177044638410302 bayes_pls_golite062009
methylenetetrahydrofolate dehydrogenase activity 0.124826575912808 bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity 0.118312276550651 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.0913823272876781 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle