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View Structure Prediction Details

Protein: gi|92859641, gi|...
Organism: Homo sapiens
Length: 307 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|92859641, gi|....

Description E-value Query
Range
Subject
Range
gi|25167087, gi|... - gi|33636701|ref|NP_004605.2| thymidine kinase 2, mitochondrial [Homo sapiens], gi|25167087|gb|AAN738...
3.0E-67 [1..307] [1..307]
gi|114662961 - gi|114662961|ref|XP_511013.2| PREDICTED: thymidine kinase 2, mitochondrial [Pan troglodytes]
7.0E-66 [1..307] [1..307]
gi|109128810 - gi|109128810|ref|XP_001083029.1| PREDICTED: similar to thymidine kinase 2, mitochondrial [Macaca mul...
6.0E-48 [43..307] [1..265]
gi|76640766 - gi|76640766|ref|XP_872360.1| PREDICTED: similar to thymidine kinase 2, mitochondrial [Bos taurus]
7.0E-48 [31..307] [2..273]
KITM_MACFA - Thymidine kinase 2, mitochondrial OS=Macaca fascicularis GN=TK2 PE=2 SV=1
3.0E-47 [43..307] [1..265]
gi|6424683 - gi|6424683|gb|AAF08104.1|AF105217_1 thymidine kinase 2 [Mus musculus]
7.0E-46 [43..305] [1..268]

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Predicted Domain #1
Region A:
Residues: [1-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRPGLFKGQA PGSRRRPTAG LAVVRADSHK KEPRASGSAR PAMLLWPLRG WAARALRCFG  60
   61 PGSRGSPASG PGPRRVQRRA WPPDKEQEKE KKSVICVEGN IASGKTTCLE FFSNATDVEV 120
  121 LTEPVSKWRN VRGHNPLGLM YHDASRWGLT LQTYVQLTML DRHTRPQVSS VRLMERSIHS 180
  181 ARYIFVENLY RSGKMPEVDY VVLSEWFDWI LRNMDVSVDL IVYLRTNPET CYQRLKKRCR 240
  241 EEEKVIPLEY LEAIHHLHEE WLIKGSLFPM AAPVLVIEAD HHMERMLELF EQNRDRILTP 300
  301 ENRKHCP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.154902
Match: 1ot3A
Description: Deoxyribonucleoside kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.0681607836408 bayes_pls_golite062009
pyrophosphatase activity 1.92954258828893 bayes_pls_golite062009
DNA-dependent ATPase activity 1.09000822067541 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 1.04041661958283 bayes_pls_golite062009
helicase activity 1.0321619822241 bayes_pls_golite062009
protein-DNA loading ATPase activity 1.00391607739958 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
nucleic acid binding 0.913322399315129 bayes_pls_golite062009
DNA clamp loader activity 0.91290128595235 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.5607032154839 bayes_pls_golite062009
ATP-dependent helicase activity 0.5607032154839 bayes_pls_golite062009
DNA helicase activity 0.533349084356156 bayes_pls_golite062009
motor activity 0.50661339105747 bayes_pls_golite062009
protein binding 0.378225828131122 bayes_pls_golite062009
DNA binding 0.376487324624615 bayes_pls_golite062009
CTP synthase activity 0.318856075265301 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.160605313145072 bayes_pls_golite062009
transcription regulator activity 0.150159515184919 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.133736530545575 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
nucleotide binding 0.114848452385726 bayes_pls_golite062009
purine nucleotide binding 0.10713474095071 bayes_pls_golite062009
purine ribonucleotide binding 0.0916519414118148 bayes_pls_golite062009
ribonucleotide binding 0.0915913646217636 bayes_pls_golite062009
structure-specific DNA binding 0.0700789521444061 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.0458386180871631 bayes_pls_golite062009
DNA polymerase activity 4.95561462330096E-4 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle