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View Structure Prediction Details

Protein: RGA1_SCHPO
Organism: Schizosaccharomyces pombe 972h-
Length: 1150 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RGA1_SCHPO.

Description E-value Query
Range
Subject
Range
gi|73948425 - gi|73948425|ref|XP_541659.2| PREDICTED: similar to zinc finger protein 91 (HPF7, HTF10) [Canis famil...
581.0 [0..4] [750..419]
gi|39944790, gi|... - gi|39944790|ref|XP_361932.1| hypothetical protein MG04377.4 [Magnaporthe grisea 70-15], gb|EAA50618....
581.0 [0..89] [1142..71]
gi|76651070 - gi|76651070|ref|XP_887916.1| PREDICTED: similar to zinc finger protein 192 isoform 6 [Bos taurus]
579.0 [0..3] [634..318]

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Predicted Domain #1
Region A:
Residues: [1-73]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQRDAKKDG LLYTTNGVSP TPPKRIPVPS RQNKIEENST TKNFPHSRHT STVAGTEGGS  60
   61 SLSRRHTSAE SRK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [74-291]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALPNQQQLAQ SGLLNKEEQQ SLKRSDTSVF PKAVRKVSSS KICASCGQVI SGQYVRALGN  60
   61 IYHLECFRCH DCNSLVASKF FPIDDPTLNK QVPLCETDYF RRLDLLCASC GMALRGYYIT 120
  121 ALNKKFHIEH FTCSLCYTVF GPNDSYYEYE GKVYCHYHYS TLFAARCCGC DGPILRQFVE 180
  181 VYRNGVSQNW HVPCHMIYKF WNVKLCQKTS IETSKKKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.522879
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [292-624]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SELSQSQLRK REKHLEQKIF HIWHALSYFE EYTASCISDM LLLVSNGEFT KSVICAQKFI  60
   61 RYIEILFKGI DSLETILSSF HAKSMPYVRE AKLLCKKLVS IFALLAKCHN SDIRDVAIVQ 120
  121 DFLSLFTGLA HYLKLLIRIS LTGGLRLEQD HACKHALPQF LQTVEEARFV DQEGYDSSSF 180
  181 DMPLNLANAS SDLCYVCHSA LEEDCVLLGE IRCHIGCLSC TKCKYNNREN YDWARWNNQT 240
  241 KQIECYLCYT ESSNVSNDEP HPSFEYVSRL SQYIYLLRIA LVRLYTILME NNDSSQRKPL 300
  301 SVDPKQENVS STVETAKQAE TTASSDSFRK YAN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.08
Match: 1b8tA
Description: Cysteine-rich (intestinal) protein, CRP, CRIP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.8684204787273 bayes_pls_golite062009
transcription regulator activity 2.06804702015592 bayes_pls_golite062009
DNA binding 1.80808173029022 bayes_pls_golite062009
nucleic acid binding 1.60971311791582 bayes_pls_golite062009
protein binding 1.30321965120678 bayes_pls_golite062009
transcription factor activity 1.24900170210968 bayes_pls_golite062009
sequence-specific DNA binding 0.445717770012964 bayes_pls_golite062009
transcription activator activity 0.367834529853475 bayes_pls_golite062009
transcription factor binding 0.27835676711169 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 0.189821618942417 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.123912633676406 bayes_pls_golite062009
cytoskeletal protein binding 0.101784288585413 bayes_pls_golite062009
receptor activity 0.0887087342257975 bayes_pls_golite062009
actin binding 0.013566820730057 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.0115212357352044 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [625-710]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLNDLRHLKS SRNRKATSNE TQSSSNSTET SKLSKNVSES GKDKSPHWHS HGGSITGKSI  60
   61 VEQASSPLER RMDAFDENRA FTLDDI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [711-1043]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKVISEQRNR EHRPNAFRHM PSYTDPSYRK NSGAIYDKND GTQKGLTPKS EDAPIRYLSD  60
   61 LSNLELLFTK HVAVLILHPL VRDYYSLDEL MEMSDLRKGG FWEKFGKAFK GKDAEKKNVK 120
  121 KKGTFGVPLE ILVERNNAQS TVGTGVGVKH IPAFIGNTLA AMKRKDMSVV GVFRKNGNIR 180
  181 RLKELSDMLD VSPDSIDYEQ ETPIQLAALL KKFLRELPDP LLTFKLFGLF ITSSKLESEE 240
  241 ERMRVLHLTI CLLPKGHRDT MEVIFGFLYW VASFSHIDDE VGSKMDIHNL ATVITPNILY 300
  301 SKSNDPVDES FLAIEAVHLL IENFEKFCEV PRE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.522879
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Rho GTPase activator activity 4.58620967349979 bayes_pls_golite062009
Rac GTPase activator activity 4.48279904625182 bayes_pls_golite062009
binding 2.79128751898373 bayes_pls_golite062009
GTPase regulator activity 2.70614727793157 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.68579854252375 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 2.06038764955701 bayes_pls_golite062009
enzyme regulator activity 1.9750017471254 bayes_pls_golite062009
small GTPase regulator activity 1.95738547986197 bayes_pls_golite062009
protein binding 1.29100556128076 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.27693544428588 bayes_pls_golite062009
cytoskeletal protein binding 1.2233434243135 bayes_pls_golite062009
myosin heavy chain kinase activity 1.15190288326422 bayes_pls_golite062009
Ras GTPase activator activity 1.09070479183477 bayes_pls_golite062009
transcription regulator activity 1.08577758274384 bayes_pls_golite062009
actin binding 1.02058870188398 bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity 0.967362611034944 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.958295643211986 bayes_pls_golite062009
GTPase activator activity 0.717730683557543 bayes_pls_golite062009
diacylglycerol binding 0.61310450668925 bayes_pls_golite062009
nucleic acid binding 0.480348726111787 bayes_pls_golite062009
DNA binding 0.418154636457321 bayes_pls_golite062009
enzyme activator activity 0.298334474872045 bayes_pls_golite062009
microfilament motor activity 0.0044514849726196 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1044-1150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISLLLDDPTL FYNNAAWTSK ELYKRCEEII SQMSLDERNT PKHTASTKRK RQPIRRVTTN  60
   61 LTSDVPSGSE VADTNSLSST TKDEASPNSD AQPKPQVKPQ HAVIRDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle