YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: SMN2, SMN1
Organism: Homo sapiens
Length: 294 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMN2, SMN1.

Description E-value Query
Range
Subject
Range
SMN_PONAB - Survival motor neuron protein OS=Pongo abelii GN=SMN1 PE=2 SV=1
gi|55726440 - gi|55726440|emb|CAH89989.1| hypothetical protein [Pongo abelii]
0.0 [1..294] [1..294]
gi|736411 - gi|736411|gb|AAA64505.1| putative open reading frame; duplicate of the functional spinal muscular at...
0.0 [2..294] [1..293]
ENSMMUG000000202... - null, null
SMN_MACFA - Survival motor neuron protein OS=Macaca fascicularis GN=SMN1 PE=2 SV=1
0.0 [1..294] [1..294]
gi|114599807 - gi|114599807|ref|XP_001156488.1| PREDICTED: survival of motor neuron 1, telomeric isoform 7 [Pan tro...
0.0 [1..294] [1..297]
gi|31075799 - gi|31075799|gb|AAP42462.1| survival motor neuron [Canis familiaris]
0.0 [10..291] [1..281]
SMN_BOVIN - Survival motor neuron protein OS=Bos taurus GN=SMN1 PE=2 SV=2
0.0 [12..291] [8..285]
SMN_FELCA - Survival of motor neuron protein OS=Felis catus GN=SMN1 PE=2 SV=1
0.0 [1..291] [1..288]

Back

Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF KHALKNGDIC  60
   61 ETSGKPKTTP KR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [73-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPAKKNKSQK KNTAASLQQW KVGDKCSAIW SEDGCIYPAT IASIDFKRET CVVVYTGYGN  60
   61 REEQNLSDLL SPICEVANNI EQNAQENENE SQVS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.30103
Match: 1g5vA
Description: Survival motor neuron protein 1, smn
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.8914433770482 bayes_pls_golite062009
transcription regulator activity 2.23645140702533 bayes_pls_golite062009
protein binding 1.97653343528228 bayes_pls_golite062009
DNA binding 1.38254179968032 bayes_pls_golite062009
nucleic acid binding 1.29663886491206 bayes_pls_golite062009
transcription cofactor activity 0.85415557686977 bayes_pls_golite062009
transcription repressor activity 0.81676066297927 bayes_pls_golite062009
transcription factor binding 0.77325691466894 bayes_pls_golite062009
transcription factor activity 0.567394926956068 bayes_pls_golite062009
N-methyltransferase activity 0.53946303154276 bayes_pls_golite062009
chromatin binding 0.25107231011304 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 0.223495463070134 bayes_pls_golite062009
histone methyltransferase activity 0.21258120552184 bayes_pls_golite062009
transcription coactivator activity 0.0304922925916231 bayes_pls_golite062009
histone binding 0.0149490634137095 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [167-294]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDESENSRSP GNKSDNIKPK SAPWNSFLPP PPPMPGPRLG PGKPGLKFNG PPPPPPPPPP  60
   61 HLLSCWLPPF PSGPPIIPPP PPICPDSLDD ADALGSMLIS WYMSGYHTGY YMGFRQNQKE 120
  121 GRCSHSLN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle