Protein Overview: SMN2, SMN1

General Information:
Name(s) found:	SMN2 [HGNC (HUGO)] SMN1 [HGNC (HUGO)]
Description(s) found: Found 54 descriptions. SHOW ALL	survival of motor neuron 2, centromeric [HGNC (HUGO)] survival of motor neuron 1, telomeric [HGNC (HUGO)]
Organism:	Homo sapiens
Length:	294 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF KHALKNGDIC  60
   61 ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA IWSEDGCIYP ATIASIDFKR 120
  121 ETCVVVYTGY GNREEQNLSD LLSPICEVAN NIEQNAQENE NESQVSTDES ENSRSPGNKS 180
  181 DNIKPKSAPW NSFLPPPPPM PGPRLGPGKP GLKFNGPPPP PPPPPPHLLS CWLPPFPSGP 240
  241 PIIPPPPPIC PDSLDDADAL GSMLISWYMS GYHTGYYMGF RQNQKEGRCS HSLN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..72]	MSA	1.135974	View MSA. No confident structure predictions are available.
2	View Details	[73..166]	PSI-BLAST	28.30103	Survival motor neuron protein 1, smn
3	View Details	[167..294]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
binding	2.8914433770482	bayes_pls_golite062009
transcription regulator activity	2.23645140702533	bayes_pls_golite062009
protein binding	1.97653343528228	bayes_pls_golite062009
DNA binding	1.38254179968032	bayes_pls_golite062009
nucleic acid binding	1.29663886491206	bayes_pls_golite062009
transcription cofactor activity	0.85415557686977	bayes_pls_golite062009
transcription repressor activity	0.81676066297927	bayes_pls_golite062009
transcription factor binding	0.77325691466894	bayes_pls_golite062009
transcription factor activity	0.567394926956068	bayes_pls_golite062009
N-methyltransferase activity	0.53946303154276	bayes_pls_golite062009
chromatin binding	0.25107231011304	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.223495463070134	bayes_pls_golite062009
histone methyltransferase activity	0.21258120552184	bayes_pls_golite062009
transcription coactivator activity	0.0304922925916231	bayes_pls_golite062009
histone binding	0.0149490634137095	bayes_pls_golite062009

3

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle