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View Structure Prediction Details

Protein: clp-3
Organism: Caenorhabditis elegans
Length: 702 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for clp-3.

Description E-value Query
Range
Subject
Range
gi|49900979 - gi|49900979|gb|AAH75862.1| CAPN1 protein [Homo sapiens]
606.0 [0..163] [701..3]

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Predicted Domain #1
Region A:
Residues: [1-179]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATDDYNFPS ITTASSEVDS PEEEYEDDKE TDAYNFSTIT NESSEVARQR EEENKDEKEI  60
   61 ARTSFSSISE HDEKIHAYNF SEILKEFVGD DCGDVAGKLF DQLSSMIPRD SVGRGLTNIF 120
  121 SSRELESLAG DLISKNSHDF VAVNSETGGI NGALAGNEMF NMGGETNSLS SIGKIVLDN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [180-702]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVSGKFKREC HVYVPLSCQP IYFHEERQKC LDEKRLFEDP QFPANNSSIY VKVRPKDHIV  60
   61 WKRPGELFAN PRLIGSDKTH FDVKLGRLEN RWFLSGAANL SLRDELFYRV VPPDQSFTEK 120
  121 YAGIFHFQFW RYGEWVDVVI DDRLPTVNGT LCYMSSPGGS EFWGPLLEKA YAKLLGTYEH 180
  181 LNDPYTEQAL WQASASFTGG LTQWFDIFMA DEMAVLAMIM RGVQMGSLIV CLNIDVNEKG 240
  241 VRQKNGLIKG YGYCITGVNL METEWEKAPL IRIRSPWGKV KWKGDFCYRS HRWFGLDKEK 300
  301 RESFRIKEDG EFWMSLKDFM VEFTDVYCCN LSADTMHEVE KMTEVKVMEH QSQQWIQASF 360
  361 EGEWSSRIGT AGGCDDHDTF CTNLQYEIHF RATDSYDSNH KCTIIAALFQ KNRDHCVYKG 420
  421 LELFLIGLLV YEMPGPNEKV TPEMVKSQTP IADSKLFKDS REANIRFTVP LGHYVIVPST 480
  481 YDPDQDGEFL LRIFTNVDFD KTHALSNGIG LICKSDGHLL TVP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.0
Match: 1kfuL
Description: Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.28868056127375 bayes_pls_golite062009
cysteine-type peptidase activity 3.05412701733177 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.01472402774099 bayes_pls_golite062009
hydrolase activity 2.29464693834116 bayes_pls_golite062009
endopeptidase activity 2.26699762664334 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.77258741259391 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.07520173658976 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.896934807256194 bayes_pls_golite062009
cytoskeletal protein binding 0.833714375875501 bayes_pls_golite062009
calcium ion binding 0.687204894708051 bayes_pls_golite062009
ubiquitin-specific protease activity 0.495368836247989 bayes_pls_golite062009
nucleic acid binding 0.313326619937245 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
DNA binding 0.053663265361386 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle