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View Structure Prediction Details

Protein: HSPA5
Organism: Homo sapiens
Length: 654 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSPA5.

Description E-value Query
Range		 Subject
Range
GRP78_CHICK - 78 kDa glucose-regulated protein OS=Gallus gallus GN=HSPA5 PE=1 SV=1
gi|118197129 - gi|118197129|dbj|BAF37040.1| heat shock protein 70kDa [Coturnix japonica]
 0.0 [18..654] [16..652]
GRP78_RAT - 78 kDa glucose-regulated protein OS=Rattus norvegicus GN=Hspa5 PE=1 SV=1
 0.0 [18..654] [18..654]
gi|90188, gi|304510 - gi|90188|pir||A27414 dnaK-type molecular chaperone GRP78 precursor - Chinese hamster, gi|304510|gb|A...
GRP78_MESAU - 78 kDa glucose-regulated protein OS=Mesocricetus auratus GN=HSPA5 PE=1 SV=1
contaminant_GR78... -
0.0 [18..654] [18..654]
gi|86577744 - gi|86577744|gb|AAI12964.1| HSPA5 protein [Homo sapiens]
GRP78_MOUSE - 78 kDa glucose-regulated protein OS=Mus musculus GN=Hspa5 PE=1 SV=3
gi|53734307 - gb|AAH83945.1| Unknown (protein for MGC:97941) [Xenopus laevis]
 0.0 [18..654] [19..655]
gi|108707472, gi... - gi|125585785|gb|EAZ26449.1| hypothetical protein OsJ_10337 [Oryza sativa Japonica Group], gi|1154522...
 0.0 [28..651] [8..634]
GRP78_BOVIN - 78 kDa glucose-regulated protein OS=Bos taurus GN=HSPA5 PE=2 SV=1
 0.0 [16..654] [17..655]
gi|68437749 - gi|68437749|ref|XP_699722.1| PREDICTED: similar to heat shock protein 70.2 [Danio rerio]
 0.0 [27..635] [84..692]

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Predicted Domain #1
Region A:
Residues: [1-582] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSLVAAML LLLSAARAEE EDKKEDVGTV VGIDLGTTYS CVGVFKNGRV EIIANDQGNR  60
   61 ITPSYVAFTP EGERLIGDAA KNQLTSNPEN TVFDAKRLIG RTWNDPSVQQ DIKFLPFKVV 120
  121 EKKTKPYIQV DIGGGQTKTF APEEISAMVL TKMKETAEAY LGKKVTHAVV TVPAYFNDAQ 180
  181 RQATKDAGTI AGLNVMRIIN EPTAAAIAYG LDKREGEKNI LVFDLGGGTF DVSLLTIDNG 240
  241 VFEVVATNGD THLGGEDFDQ RVMEHFIKLY KKKTGKDVRK DNRAVQKLRR EVEKAKRALS 300
  301 SQHQARIEIE SFYEGEDFSE TLTRAKFEEL NMDLFRSTMK PVQKVLEDSD LKKSDIDEIV 360
  361 LVGGSTRIPK IQQLVKEFFN GKEPSRGINP DEAVAYGAAV QAGVLSGDQD TGDLVLLDVC 420
  421 PLTLGIETVG GVMTKLIPRN TVVPTKKSQI FSTASDNQPT VTIKVYEGER PLTKDNHLLG 480
  481 TFDLTGIPPA PRGVPQIEVT FEIDVNGILR VTAEDKGTGN KNKITITNDQ NRLTPEEIER 540
  541 MVNDAEKFAE EDKKLKERID TRNELESYAY SLKNQIGDKE KL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1yuwA
Description: crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 7.97191512372019 bayes_pls_golite062009
structural molecule activity 3.59589495899762 bayes_pls_golite062009
structural constituent of cytoskeleton 2.46121037473545 bayes_pls_golite062009
carbohydrate kinase activity 2.33338276303563 bayes_pls_golite062009
cytoskeletal protein binding 2.20983242331685 bayes_pls_golite062009
binding 2.11855816699924 bayes_pls_golite062009
protein binding 2.00711904074672 bayes_pls_golite062009
hydrolase activity 1.88613511243568 bayes_pls_golite062009
hexokinase activity 1.70516840340504 bayes_pls_golite062009
transcription regulator activity 1.68670098354938 bayes_pls_golite062009
nucleic acid binding 1.43834016708999 bayes_pls_golite062009
peptidase activity 1.4127499531612 bayes_pls_golite062009
DNA binding 1.36804228074586 bayes_pls_golite062009
transporter activity 1.2883466875237 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.16749728168925 bayes_pls_golite062009
kinase activity 1.11102445353265 bayes_pls_golite062009
actin binding 1.03829083423378 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.953663805249074 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.900931843471417 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.898645342556399 bayes_pls_golite062009
pyrophosphatase activity 0.875671218597808 bayes_pls_golite062009
substrate-specific transporter activity 0.796517590178929 bayes_pls_golite062009
transcription factor activity 0.783439770973386 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.78242344952806 bayes_pls_golite062009
protein transporter activity 0.780308299678282 bayes_pls_golite062009
ATPase activity 0.687771333492666 bayes_pls_golite062009
myosin binding 0.607451856096 bayes_pls_golite062009
glucose binding 0.53527958884988 bayes_pls_golite062009
glucokinase activity 0.47468456642723 bayes_pls_golite062009
catalytic activity 0.296484721581333 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.186218331473028 bayes_pls_golite062009
chromatin binding 0.155140608043269 bayes_pls_golite062009
protease binding 0.121259015422625 bayes_pls_golite062009
chaperone binding 0.00111313452804307 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [583-654] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGKLSSEDKE TMEKAVEEKI EWLESHQDAD IEDFKAKKKE LEEIVQPIIS KLYGSAGPPP  60
   61 TGEEDTAEKD EL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.39794
Match: 1dkxA
Description: DnaK
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle