YRC Public Data Repository - Protein Structure Prediction

Protein:	ATOX1
Organism:	Homo sapiens
Length:	68 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATOX1.

Description	E-value	Query Range	Subject Range
gi\|22003413 - gi\|22003413\|gb\|AAM88668.1\|AF390440_4 copper transporter [Pseudomonas putida]	91.0	[0..2]	[68..71]
gi\|77380892, gi\|... - gi\|77456889\|ref\|YP_346394.1\| copper-translocating P-type ATPase [Pseudomonas fluorescens Pf0-1], gi\|...	89.0	[0..2]	[68..71]
gi\|115421723, gi... - gi\|187477137\|ref\|YP_785161.1\| copper-transporting P-type ATPase [Bordetella avium 197N], gi\|11542172...	87.0	[0..4]	[67..61]
gi\|37527684, gi\|... - gi\|37527684\|ref\|NP_931028.1\| copper exporting ATPase [Photorhabdus luminescens subsp. laumondii TTO1...	87.0	[0..9]	[68..184]
gi\|120405401, gi... - gi\|90205999\|ref\|ZP_01208636.1\| ATPase, E1-E2 type:Copper-translocating P-type ATPase:Heavy metal tra...	86.0	[0..1]	[66..1]
gi\|111020526, gi... - gi\|111020526\|ref\|YP_703498.1\| cation transport ATPase [Rhodococcus jostii RHA1], gi\|110820056\|gb\|ABG...	86.0	[0..2]	[68..13]
gi\|108800912, gi... - gi\|108800912\|ref\|YP_641109.1\| heavy metal translocating P-type ATPase [Mycobacterium sp. MCS], gi\|10... gi\|92917012, gi\|... - gi\|92917012\|ref\|ZP_01285628.1\| ATPase, E1-E2 type:Copper-translocating P-type ATPase:Heavy metal tra... gi\|92910547, gi\|... - gi\|92910547\|ref\|ZP_01279322.1\| ATPase, E1-E2 type:Copper-translocating P-type ATPase:Heavy metal tra...	86.0	[0..1]	[64..1]
gi\|16418854, gi\|... - gi\|16763733\|ref\|NP_459348.1\| putative cation transport ATPase [Salmonella typhimurium LT2], gi\|16418... gi\|205329472, gi... - gi\|205329472\|gb\|EDZ16236.1\| copper-translocating P-type ATPase [Salmonella enterica subsp. enterica ... lcl\|NC_016856.1_... - [gene=STM14_0412] [protein=putative cation transport ATPase] [protein_id=YP_005236028.1] [location=3...	86.0	[0..6]	[67..14]
gi\|89343006, gi\|... - gi\|89343006\|ref\|ZP_01195236.1\| ATPase, E1-E2 type:Copper-translocating P-type ATPase:Heavy metal tra...	85.0	[0..1]	[66..1]
gi\|70734212, gi\|... - gi\|70734212\|ref\|YP_257852.1\| copper-translocating P-type ATPase [Pseudomonas fluorescens Pf-5], gi\|6...	85.0	[0..2]	[68..71]

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Predicted Domain #1

Region A:
Residues: [1-68]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT LLATLKKTGK  60
   61 TVSYLGLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.69897
Match:	1fe0A
Description:	ATX1 metallochaperone protein (ATOX1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
copper chaperone activity	6.14761367748172	bayes_pls_golite062009
metallochaperone activity	5.42894566783157	bayes_pls_golite062009
copper ion binding	5.32798570870322	bayes_pls_golite062009
copper-dependent protein binding	4.95395467138629	bayes_pls_golite062009
copper ion transmembrane transporter activity	4.35398003989182	bayes_pls_golite062009
copper-exporting ATPase activity	4.01340421656566	bayes_pls_golite062009
copper-transporting ATPase activity	3.98014937932947	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	3.67313485213724	bayes_pls_golite062009
metal ion transmembrane transporter activity	3.36143792136115	bayes_pls_golite062009
superoxide dismutase copper chaperone activity	3.23752773949358	bayes_pls_golite062009
cation transmembrane transporter activity	3.07976644601593	bayes_pls_golite062009
ion transmembrane transporter activity	3.00431429991351	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	2.81498319767782	bayes_pls_golite062009
metal ion binding	2.69806984896689	bayes_pls_golite062009
cation binding	2.69806984896689	bayes_pls_golite062009
ion binding	2.69078950610234	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.64028711724976	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	2.63703148987083	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	2.38802353099961	bayes_pls_golite062009
transition metal ion binding	2.33752521414572	bayes_pls_golite062009
binding	2.10099654348697	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	1.89914790023437	bayes_pls_golite062009
transporter activity	1.18017764841747	bayes_pls_golite062009
transmembrane transporter activity	1.01970137875178	bayes_pls_golite062009
protein binding	0.889287086236279	bayes_pls_golite062009
substrate-specific transporter activity	0.841996187774093	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.508360443861132	bayes_pls_golite062009
pyrophosphatase activity	0.470327716716451	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.452477805627897	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.45132236262635	bayes_pls_golite062009
ATPase activity	0.392266185712579	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: