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View Structure Prediction Details

Protein: CCNA1
Organism: Homo sapiens
Length: 465 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCNA1.

Description E-value Query
Range
Subject
Range
gi|114649348 - gi|114649348|ref|XP_522658.2| PREDICTED: cyclin A1 [Pan troglodytes]
0.0 [1..465] [1..465]
gi|23271353, gi|... - gi|23271353|gb|AAH36346.1| Cyclin A1 [Homo sapiens], gi|161377468|ref|NP_001104515.1| cyclin A1 isof...
gi|123980800, gi... - gi|61363960|gb|AAX42470.1| cyclin A1 [synthetic construct], gi|123995625|gb|ABM85414.1| cyclin A1 [s...
0.0 [1..465] [1..464]
gi|54696022 - gi|54696022|gb|AAV38383.1| cyclin A1 [synthetic construct]
0.0 [1..465] [1..464]
gi|109120472 - gi|109120472|ref|XP_001084161.1| PREDICTED: similar to cyclin A1 isoform 5 [Macaca mulatta]
0.0 [1..465] [1..465]
gi|67972280 - gi|67972280|dbj|BAE02482.1| unnamed protein product [Macaca fascicularis]
0.0 [45..465] [1..421]
gi|73993336 - gi|73993336|ref|XP_534494.2| PREDICTED: similar to cyclin A1 (predicted) [Canis familiaris]
0.0 [17..465] [13..458]
CCNA1_RAT - Cyclin-A1 OS=Rattus norvegicus GN=Ccna1 PE=2 SV=1
0.0 [45..465] [1..421]

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Predicted Domain #1
Region A:
Residues: [1-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METGFPAIMY PGSFIGGWGE EYLSWEGPGL PDFVFQQQPV ESEAMHCSNP KSGVVLATVA  60
   61 RGPDACQILT RAPLGQDPPQ RTVLGLLTAN GQYRRTCGQG ITRIRCYSGS ENAFPPAGKK 120
  121 ALPDCGVQEP PKQGFDIYMD ELEQGDRDSC SVREGMAFED VYEVDTGTLK SDLHFLLDFN 180
  181 TVSPMLVDSS LLSQSEDISS LG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [203-465]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDVINVTEYA EEIYQYLREA EIRHRPKAHY MKKQPDITEG MRTILVDWLV EVGEEYKLRA  60
   61 ETLYLAVNFL DRFLSCMSVL RGKLQLVGTA AMLLASKYEE IYPPEVDEFV YITDDTYTKR 120
  121 QLLKMEHLLL KVLAFDLTVP TTNQFLLQYL RRQGVCVRTE NLAKYVAELS LLEADPFLKY 180
  181 LPSLIAAAAF CLANYTVNKH FWPETLAAFT GYSLSEIVPC LSELHKAYLD IPHRPQQAIR 240
  241 EKYKASKYLC VSLMEPPAVL LLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.39794
Match: 2g9xB
Description: No description for 2g9xB was found.

Predicted functions:

Term Confidence Notes
cyclin-dependent protein kinase regulator activity 6.12919068656167 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.12827250610292 bayes_pls_golite062009
protein kinase regulator activity 2.90083336559452 bayes_pls_golite062009
kinase regulator activity 2.84789294954357 bayes_pls_golite062009
transcription regulator activity 2.795846725429 bayes_pls_golite062009
protein binding 2.52152158357422 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.48221490125294 bayes_pls_golite062009
binding 2.4204867358489 bayes_pls_golite062009
kinase activity 2.08647385323766 bayes_pls_golite062009
DNA binding 1.94297811210385 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.84968566707266 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.82597776634075 bayes_pls_golite062009
nucleic acid binding 1.74388377119212 bayes_pls_golite062009
protein kinase activity 1.73493007274545 bayes_pls_golite062009
transcription activator activity 1.39881476204374 bayes_pls_golite062009
transferase activity 1.22899842599006 bayes_pls_golite062009
transcription factor activity 1.21921365719206 bayes_pls_golite062009
protein serine/threonine kinase activity 1.10605831730114 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.09952334871968 bayes_pls_golite062009
sequence-specific DNA binding 0.907121673967035 bayes_pls_golite062009
transcription factor binding 0.749278791251235 bayes_pls_golite062009
enzyme regulator activity 0.729629809946521 bayes_pls_golite062009
kinase binding 0.451409627821468 bayes_pls_golite062009
cytoskeletal protein binding 0.379573651859994 bayes_pls_golite062009
enzyme binding 0.145967754156613 bayes_pls_golite062009
transcription coactivator activity 0.138191616709499 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle