YRC Public Data Repository - Protein Structure Prediction

Protein:	ZNF281
Organism:	Homo sapiens
Length:	895 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ZNF281.

Description	E-value	Query Range	Subject Range
gi\|55930908 - gi\|55930908\|gb\|AAH51905.1\| Zinc finger protein 281 [Homo sapiens]	0.0	[1..895]	[1..895]
ZN281_MOUSE - Zinc finger protein 281 OS=Mus musculus GN=Znf281 PE=1 SV=1	0.0	[38..895]	[37..893]
gi\|114571717 - gi\|114571717\|ref\|XP_525015.2\| PREDICTED: zinc finger protein 281 [Pan troglodytes]	0.0	[180..895]	[84..799]
gi\|58865628, gi\|... - gi\|58865628\|ref\|NP_001012030.1\| zinc finger protein 281 [Rattus norvegicus], gi\|53733788\|gb\|AAH83844...	0.0	[38..895]	[32..889]
gi\|50750932 - gi\|50750932\|ref\|XP_422191.1\| PREDICTED: similar to Zinc finger protein 281 (Zinc finger DNA binding ...	0.0	[175..895]	[252..965]
gi\|73970462 - gi\|73970462\|ref\|XP_531880.2\| PREDICTED: similar to Zinc finger protein 208 [Canis familiaris]	0.0	[13..557]	[341..920]
gi\|109125970 - gi\|109125970\|ref\|XP_001115785.1\| PREDICTED: similar to zinc finger protein 665 [Macaca mulatta]	0.0	[14..523]	[250..738]

Back

Predicted Domain #1

Region A:
Residues: [1-90]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIGSGFLSG GGGTGSSGGS GSGGGGSGGG GGGGSSGRRA EMEPTFPQGM VMFNHRLPPV  60
   61 TSFTRPAGSA APPPQCVLSS STSAAPAAEP

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.02
Match:	1jchA
Description:	Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [91-150]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPPAPDMTF KKEPAASAAA FPSQRTSWGF LQSLVSIKQE KPADPEEQQS HHHHHHHHYG  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.30103
Match:	1tf6A
Description:	Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
transcription coactivator activity	0.912796194488319	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009
structure-specific DNA binding	0.240825841910931	bayes_pls_golite062009
double-stranded DNA binding	0.0129353639725593	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [151-347]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLFAGAEERS PGLGGGEGGS HGVIQDLSIL HQHVQQQPAQ HHRDVLLSSS SRTDDHHGTE  60
   61 EPKQDTNVKK AKRPKPESQG IKAKRKPSAS SKPSLVGDGE GAILSPSQKP HICDHCSAAF 120
  121 RSSYHLRRHV LIHTGERPFQ CSQCSMGFIQ KYLLQRHEKI HSREKPFGCD QCSMKFIQKY 180
  181 HMERHKRTHS GEKPYKC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.522879
Match:	2i13A
Description:	No description for 2i13A was found.

Predicted Domain #4

Region A:
Residues: [348-520]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTCQQYFSRT DRLLKHRRTC GEVIVKGATS AEPGSSNHTN MGNLAVLSQG NTSSSRRKTK  60
   61 SKSIAIENKE QKTGKTNESQ ISNNINMQSY SVEMPTVSSS GGIIGTGIDE LQKRVPKLIF 120
  121 KKGSRKNTDK NYLNFVSPLP DIVGQKSLSG KPSGSLGIVS NNSVETIGLL QST

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.522879
Match:	2gliA
Description:	Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
transcription coactivator activity	0.912796194488319	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009
structure-specific DNA binding	0.240825841910931	bayes_pls_golite062009
double-stranded DNA binding	0.0129353639725593	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [521-723]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGKQGQISSN YDDAMQFSKK RRYLPTASSN SAFSINVGHM VSQQSVIQSA GVSVLDNEAP  60
   61 LSLIDSSALN AEIKSCHDKS GIPDEVLQSI LDQYSNKSES QKEDPFNIAE PRVDLHTSGE 120
  121 HSELVQEENL SPGTQTPSND KASMLQEYSK YLQQAFEKST NASFTLGHGF QFVSLSSPLH 180
  181 NHTLFPEKQI YTTSPLECGF GQS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [724-895]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTSVLPSSLP KPPFGMLFGS QPGLYLSALD ATHQQLTPSQ ELDDLIDSQK NLETSSAFQS  60
   61 SSQKLTSQKE QKNLESSTGF QIPSQELASQ IDPQKDIEPR TTYQIENFAQ AFGSQFKSGS 120
  121 RVPMTFITNS NGEVDHRVRT SVSDFSGYTN MMSDVSEPCS TRVKTPTSQS YR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: