YRC Public Data Repository - Protein Structure Prediction

Protein:	GINS2
Organism:	Homo sapiens
Length:	185 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GINS2.

Description	E-value	Query Range	Subject Range
gi\|149038341, gi... - ref\|XP_226534.2\| similar to HSPC037 protein [Rattus norvegicus], gi\|157818647\|ref\|NP_001099660.1\| hy...	3.0E-78	[1..185]	[1..185]
PSF2_MOUSE - DNA replication complex GINS protein PSF2 OS=Mus musculus GN=Gins2 PE=1 SV=1	7.0E-78	[1..185]	[1..185]
gi\|109129412 - gi\|109129412\|ref\|XP_001082775.1\| PREDICTED: GINS complex subunit 2 (Psf2 homolog) [Macaca mulatta]	4.0E-77	[1..185]	[1..185]
gi\|114663949 - gi\|114663949\|ref\|XP_511151.2\| PREDICTED: DNA replication complex GINS protein PSF2 [Pan troglodytes]	6.0E-77	[1..185]	[1..185]
gi\|73957124 - gi\|73957124\|ref\|XP_851786.1\| PREDICTED: similar to DNA replication complex GINS protein PSF2 [Canis ...	1.0E-76	[1..185]	[1..185]
gi\|62897807 - gi\|62897807\|dbj\|BAD96843.1\| DNA replication complex GINS protein PSF2 variant [Homo sapiens]	1.0E-76	[1..185]	[1..185]
gi\|62751879, gi\|... - gi\|89269971\|emb\|CAJ81623.1\| psf2, Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) [Xenopus ...	4.0E-76	[1..185]	[1..185]
PSF2_XENLA - DNA replication complex GINS protein PSF2 OS=Xenopus laevis GN=gins2 PE=1 SV=1	1.0E-74	[1..185]	[1..185]
gi\|66267503, gi\|... - gi\|94733030\|emb\|CAK10903.1\| novel protein similar to vertebrate transporter 2, ATP-binding cassette,...	4.0E-70	[1..179]	[1..179]

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Predicted Domain #1

Region A:
Residues: [1-185]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAAEVEFLA EKELVTIIPN FSLDKIYLIG GDLGPFNPGL PVEVPLWLAI NLKQRQKCRL  60
   61 LPPEWMDVEK LEKMRDHERK EETFTPMPSP YYMELTKLLL NHASDNIPKA DEIRTLVKDM 120
  121 WDTRIAKLRV SADSFVRQQE AHAKLDNLTL MEINTSGTFL TQALNHMYKL RTNLQPLEST 180
  181 QSQDF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	79.221849
Match:	2q9qA
Description:	No description for 2q9qA was found.

Predicted functions:

Term	Confidence	Notes
3'-5' DNA helicase activity	3.30007058745861	bayes_pls_golite062009
DNA helicase activity	2.7662250039458	bayes_pls_golite062009
binding	1.71578680186328	bayes_pls_golite062009
transcription regulator activity	1.2336233528067	bayes_pls_golite062009
helicase activity	1.2110072302388	bayes_pls_golite062009
protein binding	0.495328779211482	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.406116199163083	bayes_pls_golite062009
transcription elongation regulator activity	0.37490315580617	bayes_pls_golite062009
pyrophosphatase activity	0.350000641617868	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.33576520693158	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.333445385039412	bayes_pls_golite062009
catalytic activity	0.161911144249814	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: