YRC Public Data Repository - Protein Structure Prediction

Protein:	HNRNPK
Organism:	Homo sapiens
Length:	463 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRNPK.

Description	E-value	Query Range	Subject Range
HNRPK_RABIT - Heterogeneous nuclear ribonucleoprotein K OS=Oryctolagus cuniculus GN=HNRNPK PE=2 SV=1	1.0E-82	[1..463]	[1..463]
gi\|74144445 - gi\|74144445\|dbj\|BAE36070.1\| unnamed protein product [Mus musculus]	2.0E-82	[1..463]	[1..463]
gi\|61369343 - gi\|61369343\|gb\|AAX43320.1\| heterogeneous nuclear ribonucleoprotein K [synthetic construct]	5.0E-81	[1..457]	[1..457]
gi\|126334811 - gi\|126334811\|ref\|XP_001368428.1\| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein K, is... gi\|58475965, gi\|... - gi\|74185026\|dbj\|BAE39121.1\| unnamed protein product [Mus musculus], gi\|74183280\|dbj\|BAE22563.1\| unna... ENSCJAT00000007404 - null gi\|123979648, gi... - gi\|61359196\|gb\|AAX41682.1\| heterogeneous nuclear ribonucleoprotein K [synthetic construct], gi\|12399... gi\|149758457 - gi\|149758457\|ref\|XP_001489114.1\| PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform 1 [Equ... HNRPK_MACFA - Heterogeneous nuclear ribonucleoprotein K OS=Macaca fascicularis GN=HNRNPK PE=2 SV=1 HNRPK_PONAB - Heterogeneous nuclear ribonucleoprotein K OS=Pongo abelii GN=HNRNPK PE=2 SV=1 gi\|48145659, gi\|... - pir\|\|S43363 transformation upregulated nuclear protein - human, gi\|55958546\|emb\|CAI16021.1\| heterog... gi\|109111931, gi... - gi\|109111935\|ref\|XP_001106112.1\| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein K iso... gi\|114625196, gi... - gi\|114625210\|ref\|XP_001155315.1\| PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform 22 [Pa... gi\|38197650 - gi\|38197650\|gb\|AAH61867.1\| Hnrpk protein [Rattus norvegicus] HNRPK_PONPY - Heterogeneous nuclear ribonucleoprotein K - Pongo pygmaeus (Orangutan)	8.0E-81	[1..457]	[1..457]
gi\|73946483, gi\|... - gi\|73946487\|ref\|XP_857692.1\| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein K isoform...	8.0E-81	[1..463]	[1..463]
HNRPK_BOVIN - Heterogeneous nuclear ribonucleoprotein K OS=Bos taurus GN=HNRNPK PE=2 SV=1	9.0E-81	[1..457]	[1..457]
gi\|1083569 - gi\|1083569\|pir\|\|A54143 kappa-B motif-binding phosphoprotein - mouse	2.0E-80	[1..457]	[1..457]

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Predicted Domain #1

Region A:
Residues: [1-138]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METEQPEETF PNTETNGEFG KRPAEDMEEE QAFKRSRNTD EMVELRILLQ SKNAGAVIGK  60
   61 GGKNIKALRT DYNASVSVPD SSGPERILSI SADIETIGEI LKKIIPTLEE GLQLPSPTAT 120
  121 SQLPLESDAV ECLNYQHY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.154902
Match:	2annA
Description:	No description for 2annA was found.

Predicted Domain #2

Region A:
Residues: [139-221]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGSDFDCELR LLIHQSLAGG IIGVKGAKIK ELRENTQTTI KLFQECCPHS TDRVVLIGGK  60
   61 PDRVVECIKI ILDLISESPI KGR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.154902
Match:	2ctmA
Description:	Solution structure of the 14th KH type I domain from human Vigilin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	6.76415077523249	bayes_pls_golite062009
mRNA binding	5.07455187994216	bayes_pls_golite062009
nucleic acid binding	3.68444148122352	bayes_pls_golite062009
binding	3.45962790790935	bayes_pls_golite062009
	2.87067043110488	bayes_pls_golite062009
poly-pyrimidine tract binding	2.05765562493656	bayes_pls_golite062009
transcription regulator activity	1.43703138180882	bayes_pls_golite062009
DNA binding	1.20852534725468	bayes_pls_golite062009
protein binding	1.16541072642796	bayes_pls_golite062009
single-stranded RNA binding	0.981003625136521	bayes_pls_golite062009
mRNA 3'-UTR binding	0.489176583045793	bayes_pls_golite062009
transcription factor activity	0.386248501195543	bayes_pls_golite062009
structure-specific DNA binding	0.32222928997178	bayes_pls_golite062009
catalytic activity	0.113112541746059	bayes_pls_golite062009
single-stranded DNA binding	0.1069917291606	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [222-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQPYDPNFYD ETYDYGGFTM MFDDRRGRPV GFPMRGRGGF DRMPPGRGGR PMPPSRRDYD  60
   61 DMSPRRGPPP PPPGRGGRGG SRARNLPL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [310-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPPPPRGGD LMAYDRRGRP GDRYDGMVGF SADETWDSAI DTWSPSEWQM AYEPQGGSGY  60
   61 DYSYAGGRGS YGDLGGPIIT TQVTIPKDLA GSIIGKGGQR IKQIRHESGA SIKIDEPLEG 120
  121 SEDRIITITG TQDQIQNAQY LLQNSVKQYS GKFF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.69897
Match:	1j5kA
Description:	HnRNP K, KH3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	6.76415077523249	bayes_pls_golite062009
mRNA binding	5.07455187994216	bayes_pls_golite062009
nucleic acid binding	3.68444148122352	bayes_pls_golite062009
binding	3.45962790790935	bayes_pls_golite062009
	2.87067043110488	bayes_pls_golite062009
poly-pyrimidine tract binding	2.05765562493656	bayes_pls_golite062009
transcription regulator activity	1.43703138180882	bayes_pls_golite062009
DNA binding	1.20852534725468	bayes_pls_golite062009
protein binding	1.16541072642796	bayes_pls_golite062009
single-stranded RNA binding	0.981003625136521	bayes_pls_golite062009
mRNA 3'-UTR binding	0.489176583045793	bayes_pls_golite062009
transcription factor activity	0.386248501195543	bayes_pls_golite062009
structure-specific DNA binding	0.32222928997178	bayes_pls_golite062009
catalytic activity	0.113112541746059	bayes_pls_golite062009
single-stranded DNA binding	0.1069917291606	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: