YRC Public Data Repository - Protein Structure Prediction

Protein:	HNRNPK
Organism:	Homo sapiens
Length:	463 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRNPK.

Description	E-value	Query Range	Subject Range
HNRPK_RABIT - Heterogeneous nuclear ribonucleoprotein K OS=Oryctolagus cuniculus GN=HNRNPK PE=2 SV=1	1.0E-82	[1..463]	[1..463]
gi\|74144445 - gi\|74144445\|dbj\|BAE36070.1\| unnamed protein product [Mus musculus]	2.0E-82	[1..463]	[1..463]
gi\|61369343 - gi\|61369343\|gb\|AAX43320.1\| heterogeneous nuclear ribonucleoprotein K [synthetic construct]	5.0E-81	[1..457]	[1..457]
gi\|126334811 - gi\|126334811\|ref\|XP_001368428.1\| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein K, is... gi\|58475965, gi\|... - gi\|74185026\|dbj\|BAE39121.1\| unnamed protein product [Mus musculus], gi\|74183280\|dbj\|BAE22563.1\| unna... ENSCJAT00000007404 - null gi\|123979648, gi... - gi\|61359196\|gb\|AAX41682.1\| heterogeneous nuclear ribonucleoprotein K [synthetic construct], gi\|12399... gi\|149758457 - gi\|149758457\|ref\|XP_001489114.1\| PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform 1 [Equ... HNRPK_MACFA - Heterogeneous nuclear ribonucleoprotein K OS=Macaca fascicularis GN=HNRNPK PE=2 SV=1 HNRPK_PONAB - Heterogeneous nuclear ribonucleoprotein K OS=Pongo abelii GN=HNRNPK PE=2 SV=1 gi\|48145659, gi\|... - pir\|\|S43363 transformation upregulated nuclear protein - human, gi\|55958546\|emb\|CAI16021.1\| heterog... gi\|109111931, gi... - gi\|109111935\|ref\|XP_001106112.1\| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein K iso... gi\|114625196, gi... - gi\|114625210\|ref\|XP_001155315.1\| PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform 22 [Pa... gi\|38197650 - gi\|38197650\|gb\|AAH61867.1\| Hnrpk protein [Rattus norvegicus] HNRPK_PONPY - Heterogeneous nuclear ribonucleoprotein K - Pongo pygmaeus (Orangutan)	8.0E-81	[1..457]	[1..457]
gi\|73946483, gi\|... - gi\|73946487\|ref\|XP_857692.1\| PREDICTED: similar to heterogeneous nuclear ribonucleoprotein K isoform...	8.0E-81	[1..463]	[1..463]
HNRPK_BOVIN - Heterogeneous nuclear ribonucleoprotein K OS=Bos taurus GN=HNRNPK PE=2 SV=1	9.0E-81	[1..457]	[1..457]
gi\|1083569 - gi\|1083569\|pir\|\|A54143 kappa-B motif-binding phosphoprotein - mouse	2.0E-80	[1..457]	[1..457]

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Predicted Domain #1

Region A:
Residues: [1-138]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METEQPEETF PNTETNGEFG KRPAEDMEEE QAFKRSRNTD EMVELRILLQ SKNAGAVIGK  60
   61 GGKNIKALRT DYNASVSVPD SSGPERILSI SADIETIGEI LKKIIPTLEE GLQLPSPTAT 120
  121 SQLPLESDAV ECLNYQHY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.154902
Match:	2annA
Description:	No description for 2annA was found.

Predicted Domain #2

Region A:
Residues: [139-221]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGSDFDCELR LLIHQSLAGG IIGVKGAKIK ELRENTQTTI KLFQECCPHS TDRVVLIGGK  60
   61 PDRVVECIKI ILDLISESPI KGR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.154902
Match:	2ctmA
Description:	Solution structure of the 14th KH type I domain from human Vigilin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	6.76415077523249	bayes_pls_golite062009
mRNA binding	5.07455187994216	bayes_pls_golite062009
nucleic acid binding	3.68444148122352	bayes_pls_golite062009
binding	3.45962790790935	bayes_pls_golite062009
	2.87067043110488	bayes_pls_golite062009
poly-pyrimidine tract binding	2.05765562493656	bayes_pls_golite062009
transcription regulator activity	1.43703138180882	bayes_pls_golite062009
DNA binding	1.20852534725468	bayes_pls_golite062009
protein binding	1.16541072642796	bayes_pls_golite062009
single-stranded RNA binding	0.981003625136521	bayes_pls_golite062009
mRNA 3'-UTR binding	0.489176583045793	bayes_pls_golite062009
transcription factor activity	0.386248501195543	bayes_pls_golite062009
structure-specific DNA binding	0.32222928997178	bayes_pls_golite062009
catalytic activity	0.113112541746059	bayes_pls_golite062009
single-stranded DNA binding	0.1069917291606	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [222-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQPYDPNFYD ETYDYGGFTM MFDDRRGRPV GFPMRGRGGF DRMPPGRGGR PMPPSRRDYD  60
   61 DMSPRRGPPP PPPGRGGRGG SRARNLPL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.678	d.19.1	MHC antigen-recognition domain
View	Download	0.474	d.52.1	Alpha-lytic protease prodomain
View	Download	0.462	b.71.1	Glycosyl hydrolase domain
View	Download	0.332	d.19.1	MHC antigen-recognition domain
View	Download	0.317	d.222.1	YbaB-like

Predicted Domain #4

Region A:
Residues: [310-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPPPPPRGGD LMAYDRRGRP GDRYDGMVGF SADETWDSAI DTWSPSEWQM AYEPQGGSGY  60
   61 DYSYAGGRGS YGDLGGPIIT TQVTIPKDLA GSIIGKGGQR IKQIRHESGA SIKIDEPLEG 120
  121 SEDRIITITG TQDQIQNAQY LLQNSVKQYS GKFF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.69897
Match:	1j5kA
Description:	HnRNP K, KH3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	6.76415077523249	bayes_pls_golite062009
mRNA binding	5.07455187994216	bayes_pls_golite062009
nucleic acid binding	3.68444148122352	bayes_pls_golite062009
binding	3.45962790790935	bayes_pls_golite062009
	2.87067043110488	bayes_pls_golite062009
poly-pyrimidine tract binding	2.05765562493656	bayes_pls_golite062009
transcription regulator activity	1.43703138180882	bayes_pls_golite062009
DNA binding	1.20852534725468	bayes_pls_golite062009
protein binding	1.16541072642796	bayes_pls_golite062009
single-stranded RNA binding	0.981003625136521	bayes_pls_golite062009
mRNA 3'-UTR binding	0.489176583045793	bayes_pls_golite062009
transcription factor activity	0.386248501195543	bayes_pls_golite062009
structure-specific DNA binding	0.32222928997178	bayes_pls_golite062009
catalytic activity	0.113112541746059	bayes_pls_golite062009
single-stranded DNA binding	0.1069917291606	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: