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View Structure Prediction Details

Protein: JRKL
Organism: Homo sapiens
Length: 524 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for JRKL.

Description E-value Query
Range
Subject
Range
gi|34860486, gi|... - gi|34860486|ref|XP_235818.2| PREDICTED: similar to jerky homolog-like [Rattus norvegicus], gi|157822...
0.0 [1..524] [1..524]
JERKL_MOUSE - Jerky protein homolog-like OS=Mus musculus GN=Jrkl PE=2 SV=1
0.0 [1..524] [1..523]
gi|109108409 - gi|109108409|ref|XP_001094262.1| PREDICTED: similar to jerky homolog-like [Macaca mulatta]
0.0 [1..524] [1..524]
gi|57102284 - gi|57102284|ref|XP_533970.1| PREDICTED: similar to jerky homolog-like [Canis familiaris]
0.0 [1..524] [1..524]
gi|61818515 - gi|61818515|ref|XP_589056.1| PREDICTED: similar to jerky homolog-like [Bos taurus]
0.0 [1..524] [1..524]
TIGD2 - tigger transposable element derived 2
0.0 [1..521] [1..521]

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Predicted Domain #1
Region A:
Residues: [1-148]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGKRKRVVL TIKDKLDIIK KLEDGGSSKQ LAVIYGIGET TVRDIRKNKE KIITYASSSD  60
   61 STSLLAKRKS MKPSMYEELD RAMLEWFNQQ RAKGNPISGP ICAKRAEFFF YALGMDGDFN 120
  121 PSAGWLTRFK QRHSIREINI RNERLNGD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.69897
Match: 1hlvA
Description: DNA-binding domain of centromere binding protein B (CENP-B)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.71840976776163 bayes_pls_golite062009
DNA binding 2.61711182194361 bayes_pls_golite062009
binding 2.59102816487173 bayes_pls_golite062009
nucleic acid binding 2.3237599869447 bayes_pls_golite062009
transcription factor activity 2.18905180070231 bayes_pls_golite062009
sequence-specific DNA binding 1.69885241317809 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.35613772918036 bayes_pls_golite062009
protein binding 0.853351196918381 bayes_pls_golite062009
transcription activator activity 0.67940033960016 bayes_pls_golite062009
transcription repressor activity 0.67392957114349 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.44172618015361 bayes_pls_golite062009
transcription factor binding 0.22865859991459 bayes_pls_golite062009
chromatin binding 0.203837749053719 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [149-392]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETAVEDFCNN FRDFIERENL QPEQIYNADE TGLFWKCLPS RISVIKGKCT VPGHKSIEER  60
   61 VTIMCCANAT GLHKLKLCVV GKAKKPRSFK STDTLNLPVS YFSQKGAWMD LSIFRQWFDK 120
  121 IFVPQVREYL RSKGLQEKAV LLLDNSPTHP NENVLRSDDG QIFAKYLPPN VASLIQPSDQ 180
  181 GVIATMKRNY RAGLLQNNLE EGNDLKSFWK KLTLLDALYE IAMAWNLVKP VTISRAWKKI 240
  241 LPMV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.81
Match: 2f7tA
Description: No description for 2f7tA was found.

Predicted Domain #3
Region A:
Residues: [393-524]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEKESLDFDV EDISVATVAA ILQHTKGLEN VTTENLEKWL EVDSTEPGYE VLTDSEIIRR  60
   61 AQGQADESSE NEEEEIELIP EKHINHAAAL QWTENLLDYL EQQGDMILPD RLVIRKLRAT 120
  121 IRNKQKMTKS SQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle