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View Structure Prediction Details

Protein: gi|170650730, gi...
Organism: Homo sapiens
Length: 317 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|170650730, gi....

Description E-value Query
Range
Subject
Range
gi|38181828 - gi|38181828|gb|AAH61564.1| Pou1f1 protein [Rattus norvegicus]
2.0E-53 [1..317] [20..336]
gi|1289508, gi|1... - gi|1289508|gb|AAB51352.1| pit-1/GHF-1, gi|112421204|ref|NP_001036325.1| pituitary specific transcrip...
1.0E-52 [1..317] [1..317]
gi|88174213 - gi|88174213|gb|ABD39233.1| pituitary transcription factor 1 beta variant [Ovis aries]
5.0E-52 [1..317] [1..317]
gi|114588000 - gi|114588000|ref|XP_526244.2| PREDICTED: POU domain, class 1, transcription factor 1 (Pit1, growth h...
7.0E-46 [1..317] [1..291]
POU1F1 - POU class 1 homeobox 1
gi|157169656 - gi|157169656|gb|AAI52852.1| POU class 1 homeobox 1 [synthetic construct]
HGNC:9210|MIM:17... - class 1 homeobox 1
2.0E-45 [1..317] [1..291]
gi|55741453 - ref|NP_001006950.1| POU domain, class 1, transcription factor 1 [Canis familiaris]
PIT1_CANLF - Pituitary-specific positive transcription factor 1 OS=Canis lupus familiaris GN=POU1F1 PE=2 SV=1
3.0E-45 [1..317] [1..291]
PIT1_BOVIN - Pituitary-specific positive transcription factor 1 OS=Bos taurus GN=POU1F1 PE=2 SV=1
1.0E-44 [1..317] [1..291]

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Predicted Domain #1
Region A:
Residues: [1-118]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCQAFTSAD TFIPLNSDAS ATLPLIMHHS AAECLPVSNH ATNVMSTVPS ILSLIQTPKC  60
   61 LCTHFSVTTL GNTATGLHYS VPSCHYGNQP STYGVMAGSL TPCLYKFPDH TLSHGFPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [119-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IHQPLLAEDP TAADFKQELR RKSKLVEEPI DMDSPEIREL EKFANEFKVR RIKLGYTQTN  60
   61 VGEALAAVHG SEFSQTTICR FENLQLSFKN ACKLKAILSK WLEEAEQVGA LYNEKVGANE 120
  121 RKRKRRTTIS IAAKDALERH FGEQNKPSSQ EIMRMAEELN LEKEVVRVWF CNRRQREKRV 180
  181 KTSLNQSLFS ISKEHLECR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.154902
Match: 1au7A
Description: Pit-1 POU homeodomain; Pit-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.51228466689923 bayes_pls_golite062009
nucleic acid binding 5.37468811865033 bayes_pls_golite062009
transcription regulator activity 5.05236457497789 bayes_pls_golite062009
transcription factor activity 3.89464979825638 bayes_pls_golite062009
binding 3.66501723413351 bayes_pls_golite062009
sequence-specific DNA binding 3.25218945600666 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22754992035091 bayes_pls_golite062009
transcription activator activity 3.15886611325686 bayes_pls_golite062009
transcription repressor activity 1.75958281319075 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
protein binding 1.55649304400241 bayes_pls_golite062009
chromatin binding 1.2739759748489 bayes_pls_golite062009
transcription factor binding 1.02788976342343 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.92393807212912 bayes_pls_golite062009
transcription cofactor activity 0.8718993114781 bayes_pls_golite062009
transcription coactivator activity 0.81316180547536 bayes_pls_golite062009
promoter binding 0.22765608166458 bayes_pls_golite062009
catalytic activity 0.00446472034106909 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle