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View Structure Prediction Details

Protein: gi|170650730, gi...
Organism: Homo sapiens
Length: 317 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|170650730, gi....

Description E-value Query
Range
Subject
Range
gi|38181828 - gi|38181828|gb|AAH61564.1| Pou1f1 protein [Rattus norvegicus]
2.0E-53 [1..317] [20..336]
gi|1289508, gi|1... - gi|1289508|gb|AAB51352.1| pit-1/GHF-1, gi|112421204|ref|NP_001036325.1| pituitary specific transcrip...
1.0E-52 [1..317] [1..317]
gi|88174213 - gi|88174213|gb|ABD39233.1| pituitary transcription factor 1 beta variant [Ovis aries]
5.0E-52 [1..317] [1..317]
gi|114588000 - gi|114588000|ref|XP_526244.2| PREDICTED: POU domain, class 1, transcription factor 1 (Pit1, growth h...
7.0E-46 [1..317] [1..291]
POU1F1 - POU class 1 homeobox 1
gi|157169656 - gi|157169656|gb|AAI52852.1| POU class 1 homeobox 1 [synthetic construct]
HGNC:9210|MIM:17... - class 1 homeobox 1
2.0E-45 [1..317] [1..291]
gi|55741453 - ref|NP_001006950.1| POU domain, class 1, transcription factor 1 [Canis familiaris]
PIT1_CANLF - Pituitary-specific positive transcription factor 1 OS=Canis lupus familiaris GN=POU1F1 PE=2 SV=1
3.0E-45 [1..317] [1..291]
PIT1_BOVIN - Pituitary-specific positive transcription factor 1 OS=Bos taurus GN=POU1F1 PE=2 SV=1
1.0E-44 [1..317] [1..291]

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Predicted Domain #1
Region A:
Residues: [1-118]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSCQAFTSAD TFIPLNSDAS ATLPLIMHHS AAECLPVSNH ATNVMSTVPS ILSLIQTPKC  60
   61 LCTHFSVTTL GNTATGLHYS VPSCHYGNQP STYGVMAGSL TPCLYKFPDH TLSHGFPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.412 a.118.1 ARM repeat
View Download 0.241 b.6.1 Cupredoxins
View Download 0.217 a.39.1 EF-hand

Predicted Domain #2
Region A:
Residues: [119-317]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IHQPLLAEDP TAADFKQELR RKSKLVEEPI DMDSPEIREL EKFANEFKVR RIKLGYTQTN  60
   61 VGEALAAVHG SEFSQTTICR FENLQLSFKN ACKLKAILSK WLEEAEQVGA LYNEKVGANE 120
  121 RKRKRRTTIS IAAKDALERH FGEQNKPSSQ EIMRMAEELN LEKEVVRVWF CNRRQREKRV 180
  181 KTSLNQSLFS ISKEHLECR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.154902
Match: 1au7A
Description: Pit-1 POU homeodomain; Pit-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.51228466689923 bayes_pls_golite062009
nucleic acid binding 5.37468811865033 bayes_pls_golite062009
transcription regulator activity 5.05236457497789 bayes_pls_golite062009
transcription factor activity 3.89464979825638 bayes_pls_golite062009
binding 3.66501723413351 bayes_pls_golite062009
sequence-specific DNA binding 3.25218945600666 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22754992035091 bayes_pls_golite062009
transcription activator activity 3.15886611325686 bayes_pls_golite062009
transcription repressor activity 1.75958281319075 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
protein binding 1.55649304400241 bayes_pls_golite062009
chromatin binding 1.2739759748489 bayes_pls_golite062009
transcription factor binding 1.02788976342343 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.92393807212912 bayes_pls_golite062009
transcription cofactor activity 0.8718993114781 bayes_pls_golite062009
transcription coactivator activity 0.81316180547536 bayes_pls_golite062009
promoter binding 0.22765608166458 bayes_pls_golite062009
catalytic activity 0.00446472034106909 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle