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View Structure Prediction Details

Protein: OTUD6A
Organism: Homo sapiens
Length: 288 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OTUD6A.

Description E-value Query
Range
Subject
Range
gi|109131091 - gi|109131091|ref|XP_001082689.1| PREDICTED: similar to HIN-6 protease [Macaca mulatta]
2.0E-87 [1..287] [1..287]
gi|109476175, gi... - gi|157820311|ref|NP_001100109.1| OTU domain containing 6B [Rattus norvegicus], gi|149045466|gb|EDL98...
5.0E-79 [1..280] [36..320]
gi|57108027 - gi|57108027|ref|XP_544171.1| PREDICTED: similar to CG7857-PA [Canis familiaris]
7.0E-78 [13..280] [115..387]
gi|76630286 - gi|76630286|ref|XP_874339.1| PREDICTED: similar to CG7857-PA [Bos taurus]
6.0E-77 [1..280] [5..289]
OTU6A_MOUSE - OTU domain-containing protein 6A OS=Mus musculus GN=Otud6a PE=1 SV=1
3.0E-76 [1..287] [1..289]

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Predicted Domain #1
Region A:
Residues: [1-122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDPKSEQQR ILRRHQRERQ ELQAQIRSLK NSVPKTDKTK RKQLLQDVAR MEAEMAQKHR  60
   61 QELEKFQDDS SIESVVEDLA KMNLENRPPR SSKAHRKRER MESEERERQE SIFQAEMSEH 120
  121 LA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.1
Match: 1rh1A
Description: crystal structure of the cytotoxic bacterial protein colicin B at 2.5 A resolution
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [123-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFKREEEEKL AAILGARGLE MKAIPADGHC MYRAIQDQLV FSVSVEMLRC RTASYMKKHV  60
   61 DEFLPFFSNP ETSDSFGYDD FMIYCDNIVR TTAWGGQLEL RALSHVLKTP IEVIQADSPT 120
  121 LIIGEEYVKK PIILVYLRYA YSLGEHYNSV TPLEAGAAGG VLPRLL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1tffA
Description: Structure of Otubain-2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.40148357876466 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.21949433847862 bayes_pls_golite062009
cysteine-type peptidase activity 2.71117522993364 bayes_pls_golite062009
hydrolase activity 2.29464693834116 bayes_pls_golite062009
endopeptidase activity 2.26699762664334 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
binding 0.586727415287325 bayes_pls_golite062009
small conjugating protein-specific protease activity 0.500110970732392 bayes_pls_golite062009
protein binding 0.130065210618838 bayes_pls_golite062009
ubiquitin-specific protease activity 0.0101379718864654 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle