YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|10432438, gi\|...
Organism:	Homo sapiens
Length:	802 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|10432438, gi|....

Description	E-value	Query Range	Subject Range
gi\|18450371, gi\|... - gi\|35786\|emb\|CAA38065.1\| protein-tyrosine phosphatase [Homo sapiens], gi\|33096774\|emb\|CAE11878.1\| hy... gi\|123995317, gi... - gi\|123995317\|gb\|ABM85260.1\| protein tyrosine phosphatase, receptor type, A [synthetic construct], gi...	0.0	[1..802]	[1..793]
gi\|109092682 - gi\|109092682\|ref\|XP_001114682.1\| PREDICTED: similar to protein tyrosine phosphatase, receptor type, ...	0.0	[1..802]	[1..793]
gi\|114680577, gi... - gi\|114680583\|ref\|XP_001158276.1\| PREDICTED: protein tyrosine phosphatase, receptor type, A isoform 9...	0.0	[1..802]	[1..802]
gi\|194672537, gi... - gi\|76672197\|ref\|XP_594101.2\| PREDICTED: similar to protein tyrosine phosphatase, receptor type, A is...	0.0	[1..802]	[1..792]
gi\|21912410, gi\|... - gi\|83405583\|gb\|AAI10684.1\| Ptpra protein [Mus musculus], gi\|62635488\|gb\|AAX90613.1\| Ptpra [Mus muscu...	0.0	[1..802]	[1..793]

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Predicted Domain #1

Region A:
Residues: [1-208]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSWFILVLL GSGLICVSAN NATTVAPSVG ITRLINSSTA EPVKEEAKTS NPTSSLTSLS  60
   61 VAPTFSPNIT LGPTYLTTVN SSDSDNGTTR TASTNSIGIT ISPNGTWLPD NQFTDARTEP 120
  121 WEGNSSTAAT TPETFPPSGN SDSKDRRDET PIIAVMVALS SLLVIVFIII VLYMLRFKKY 180
  181 KQAGSHSNSF RLSNGRTEDV EPQSVPLL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.17
Match:	2j63A
Description:	No description for 2j63A was found.

Predicted Domain #2

Region A:
Residues: [209-255]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARSPSTNRKY PPLPVDKLEE EINRRMADDN KLFREEFNAL PACPIQA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.045757
Match:	1yfoA
Description:	Tyrosine phosphatase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [256-432]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TCEAASKEEN KEKNRYVNIL PYDHSRVHLT PVEGVPDSDY INASFINGYQ EKNKFIAAQG  60
   61 PKEETVNDFW RMIWEQNTAT IVMVTNLKER KECKCAQYWP DQGCWTYGNI RVSVEDVTVL 120
  121 VDYTVRKFCI QQVGDMTNRK PQRLITQFHF TSWPDFGVPF TPIGMLKFLK KVKACNP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.69897
Match:	1pa9A
Description:	Yersinia Protein-Tyrosine Phosphatase complexed with pNCS (Yop51,Pasteurella X,Ptpase,Yop51delta162) (Catalytic Domain, Residues 163-468) Mutant With Cys 235 Replaced By Arg (C235r)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.30669036331612	bayes_pls_golite062009
phosphatase activity	7.03758345564381	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.82821455971597	bayes_pls_golite062009
protein tyrosine phosphatase activity	6.07449851643404	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.83769298632658	bayes_pls_golite062009
receptor tyrosine kinase binding	5.39791540743613	bayes_pls_golite062009
transmembrane receptor protein phosphatase activity	4.57221148210263	bayes_pls_golite062009
transmembrane receptor protein tyrosine phosphatase activity	4.57221148210263	bayes_pls_golite062009
transmembrane receptor activity	3.4815731203374	bayes_pls_golite062009
receptor activity	3.2014960162856	bayes_pls_golite062009
protein tyrosine/serine/threonine phosphatase activity	2.77531895423367	bayes_pls_golite062009
insulin receptor binding	2.63442848340688	bayes_pls_golite062009
protein serine/threonine phosphatase activity	2.49496709551693	bayes_pls_golite062009
signal transducer activity	2.27602678801224	bayes_pls_golite062009
molecular transducer activity	2.27602678801224	bayes_pls_golite062009
protein binding	2.12487185456363	bayes_pls_golite062009
binding	2.06015698112379	bayes_pls_golite062009
non-membrane spanning protein tyrosine phosphatase activity	2.04600549829086	bayes_pls_golite062009
hydrolase activity	1.92668074108441	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.56455764981613	bayes_pls_golite062009
kinase activity	1.54798529194457	bayes_pls_golite062009
cell adhesion molecule binding	1.53727496158735	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.36326098454926	bayes_pls_golite062009
protein kinase activity	1.3466747511896	bayes_pls_golite062009
nucleic acid binding	1.24416639415232	bayes_pls_golite062009
transporter activity	1.21792561830727	bayes_pls_golite062009
DNA binding	1.19665037078743	bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity	1.1200449509328	bayes_pls_golite062009
catalytic activity	1.06283028154109	bayes_pls_golite062009
transferase activity	1.05480035577492	bayes_pls_golite062009
lipid phosphatase activity	1.05085928819585	bayes_pls_golite062009
beta-catenin binding	1.02079992407668	bayes_pls_golite062009
transmembrane transporter activity	1.00030784939308	bayes_pls_golite062009
kinase binding	0.95875467592478	bayes_pls_golite062009
delta-catenin binding	0.89195134506409	bayes_pls_golite062009
protein kinase binding	0.83725631602383	bayes_pls_golite062009
substrate-specific transporter activity	0.73846553033987	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.49044345981587	bayes_pls_golite062009
phospholipase binding	0.43589778800599	bayes_pls_golite062009
insulin receptor substrate binding	0.366350463194201	bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity	0.28805451968625	bayes_pls_golite062009
peptide hormone receptor binding	0.272080084933271	bayes_pls_golite062009
gated channel activity	0.217548650508289	bayes_pls_golite062009
ion transmembrane transporter activity	0.200180223985633	bayes_pls_golite062009
enzyme binding	0.150910330021054	bayes_pls_golite062009
receptor binding	0.0137204844761347	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [433-802]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QYAGAIVVHC SAGVGRTGTF VVIDAMLDMM HTERKVDVYG FVSRIRAQRC QMVQTDMQYV  60
   61 FIYQALLEHY LYGDTELEVT SLETHLQKIY NKIPGTSNNG LEEEFKKLTS IKIQNDKMRT 120
  121 GNLPANMKKN RVLQIIPYEF NRVIIPVKRG EENTDYVNAS FIDGYRQKDS YIASQGPLLH 180
  181 TIEDFWRMIW EWKSCSIVML TELEERGQEK CAQYWPSDGL VSYGDITVEL KKEEECESYT 240
  241 VRDLLVTNTR ENKSRQIRQF HFHGWPEVGI PSDGKGMISI IAAVQKQQQQ SGNHPITVHC 300
  301 SAGAGRTGTF CALSTVLERV KAEGILDVFQ TVKSLRLQRP HMVQTLEQYE FCYKVVQEYI 360
  361 DAFSDYANFK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.39794
Match:	2b3oA
Description:	Crystal structure of human tyrosine phosphatase SHP-1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: