YRC Public Data Repository - Protein Structure Prediction

Protein:	CSE4
Organism:	Saccharomyces cerevisiae
Length:	229 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CSE4.

Description	E-value	Query Range	Subject Range
gi\|30156584 - gi\|30156584\|ref\|XP_293312.2\| PREDICTED: similar to H3 histone, family 3B [Homo sapiens]	8.0E-56	[90..229]	[128..264]
gi\|34858260 - gi\|34858260\|ref\|XP_227461.2\| PREDICTED: similar to histone protein Hist2h3c1 [Rattus norvegicus]	8.0E-55	[86..228]	[50..189]
gi\|148706930, gi... - gi\|62739244\|gb\|AAH94041.1\| Histone cluster 2, H3c1 [Mus musculus], gi\|30061401\|ref\|NP_835734.1\| hist...	2.0E-53	[90..228]	[45..180]
CENPA_YEAST - Histone H3-like centromeric protein CSE4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... gi\|151941497 - gi\|151941497\|gb\|EDN59860.1\| chromosome segregation-related protein [Saccharomyces cerevisiae YJM789] gi\|190409778 - gi\|190409778\|gb\|EDV13043.1\| chromatin-associated protein CSE4 [Saccharomyces cerevisiae RM11-1a] gi\|207343496 - gi\|207343496\|gb\|EDZ70941.1\| YKL049Cp-like protein [Saccharomyces cerevisiae AWRI1631] CSE4 - Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of h...	3.0E-52	[1..229]	[1..229]
gi\|47085683, gi\|... - gi\|47085683\|ref\|NP_998161.1\| H3 histone, family 3A [Danio rerio], gi\|28277907\|gb\|AAH45982.1\| H3 hist...	5.0E-52	[91..228]	[1..135]
gi\|255581420, gi... - gi\|255581420\|ref\|XP_002531518.1\| histone h3, putative [Ricinus communis], gi\|255545798\|ref\|XP_002513... gi\|357110657\|ref... - PREDICTED: histone H3.3-like isoform 2 [Brachypodium distachyon], PREDICTED: histone H3.3-like isofo... gi\|224814382 - gi\|224814382\|gb\|ACN65412.1\| histone 3.2 [Pteris vittata] gi\|92870265, gi\|... - gi\|92880830\|gb\|ABE85854.1\| Histone core [Medicago truncatula], gi\|92873912\|gb\|ABE82253.1\| Histone H3... gi\|224097140, gi... - gi\|224097140\|ref\|XP_002310848.1\| histone H3 [Populus trichocarpa], gi\|224093720\|ref\|XP_002309961.1\| ... gi\|116779721, gi... - gi\|224286639\|gb\|ACN41024.1\| unknown [Picea sitchensis], gi\|224284828\|gb\|ACN40144.1\| unknown [Picea s... gi\|118489220 - gi\|118489220\|gb\|ABK96416.1\| unknown [Populus trichocarpa x Populus deltoides] gi\|192910840, gi... - gi\|192910874\|gb\|ACF06545.1\| histone H3 [Elaeis guineensis], gi\|192910840\|gb\|ACF06528.1\| histone H3 [... gi\|212721898, gi... - gi\|238013324\|gb\|ACR37697.1\| unknown [Zea mays], gi\|212721898\|ref\|NP_001131417.1\| hypothetical protei... gi\|106879571 - gi\|106879571\|emb\|CAJ38369.1\| histin H3 [Plantago major] gi\|167998945, gi... - gi\|167999225\|ref\|XP_001752318.1\| histone H3 [Physcomitrella patens subsp. patens], gi\|167999057\|ref\|... H33_CAPAN - Histone H3.3 OS=Capsicum annuum PE=2 SV=3 H33_MEDSA - Histone H3.3 OS=Medicago sativa PE=1 SV=2 gi\|1435157, gi\|1... - gi\|151413347\|gb\|ABS11142.1\| histone H3 [Solanum lycopersicum], gi\|1435157\|emb\|CAA58445.1\| histone H3... H33_GOSHI - Histone H3.3 OS=Gossypium hirsutum GN=HIS3 PE=2 SV=3 H33_ORYCO - Histone H3.3 OS=Oryza coarctata PE=2 SV=3 H33_PINPS - Histone H3.3 OS=Pinus pinaster PE=2 SV=3 H33_LOLTE - Histone H3.3 OS=Lolium temulentum PE=2 SV=2 H33_ARATH - Histone H3.3 OS=Arabidopsis thaliana GN=HTR4 PE=1 SV=2 H33_VITVI - Histone H3.3 OS=Vitis vinifera PE=2 SV=3 H33_ORYSJ - Histone H3.3 OS=Oryza sativa subsp. japonica GN=H3 PE=1 SV=2 PGSC0003DMP40005... - PGSC0003DMT400009656, PGSC0003DMT400041662, PGSC0003DMT400043254, PGSC0003DMT400079216 gi\|115394199 - gi\|115394199\|gb\|ABI97039.1\| histone H3 [Robinia pseudoacacia] H33_ORYSA - Histone H3.3 (H3.2) - Oryza sativa (Rice) H33_ORYSI - Histone H3.3 OS=Oryza sativa subsp. indica GN=OsI_011536 PE=3 SV=1 gi\|144953503 - gi\|144953503\|gb\|ABP04114.1\| histone 3 [Lemna minor] gi\|62642117 - gi\|62642117\|gb\|AAX92697.1\| histone 3 [Picea abies] H33_LOLMU - Histone H3.3 OS=Lolium multiflorum GN=RH3 PE=2 SV=3 gi\|72398499, gi\|... - gi\|72398501\|gb\|AAZ72656.1\| histone H3.2 [Craterostigma plantagineum], gi\|72398499\|gb\|AAZ72655.1\| his... H33_TOBAC - Histone H3.3 OS=Nicotiana tabacum GN=H3 PE=1 SV=1 mgf001690m, mgf0... - null, null, null, null gi\|241915979, gi... - gi\|242094532\|ref\|XP_002437756.1\| hypothetical protein SORBIDRAFT_10g002040 [Sorghum bicolor], gi\|242... gi\|255625589 - gi\|255625589\|gb\|ACU13139.1\| unknown [Glycine max]	8.0E-52	[91..228]	[1..135]
gi\|18698662 - gi\|18698662\|gb\|AAL78367.1\|AF467728_1 disease-resistent-related protein [Oryza sativa]	1.0E-51	[91..228]	[1..135]
H3C_CAIMO - Histone H3.3C OS=Cairina moschata GN=H3F3C PE=3 SV=2 gi\|224869 - gi\|224869\|prf\|\|1202296A histone H3.4	2.0E-51	[91..228]	[1..135]
gi\|156210495, gi... - gi\|156356095\|ref\|XP_001623766.1\| predicted protein [Nematostella vectensis], gi\|156210495\|gb\|EDO3166... gi\|190584176, gi... - gi\|196007812\|ref\|XP_002113772.1\| replacement histone H3.3 [Trichoplax adhaerens], gi\|190584176\|gb\|ED... gi\|221130419 - gi\|221130419\|ref\|XP_002154470.1\| PREDICTED: similar to Histone H3.3B CG8989-PA [Hydra magnipapillata... gi\|118776378 - gi\|118776378\|gb\|ABL14206.1\| histone H3.3-like protein protein [Trichinella spiralis] H33_TRIPS - Histone H3.3 OS=Trichinella pseudospiralis GN=HHT3 PE=2 SV=3	2.0E-51	[91..228]	[1..135]

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Predicted Domain #1

Region A:
Residues: [1-80]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSKQQWVSS AIQSDSSGRS LSNVNRLAGD QQSINDRALS LLQRTRATKN LFPRREERRR  60
   61 YESSKSDLDI ETDYEDQAGN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [81-229]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEIETENEEE AEMETEVPAP VRTHSYALDR YVRQKRREKQ RKQSLKRVEK KYTPSELALY  60
   61 EIRKYQRSTD LLISKIPFAR LVKEVTDEFT TKDQDLRWQS MAIMALQEAS EAYLVGLLEH 120
  121 TNLLALHAKR ITIMKKDMQL ARRIRGQFI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.522879
Match:	1eqzG_
Description:	Histone H3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	3.12722734218139	bayes_pls_golite062009
centromeric DNA binding	2.60445660474495	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.32945404683014	bayes_pls_golite062009
DNA binding	1.81202026929492	bayes_pls_golite062009
nucleic acid binding	1.77431079461635	bayes_pls_golite062009
protein binding	1.2861218811362	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.21195713556272	bayes_pls_golite062009
transcription regulator activity	1.07001118921201	bayes_pls_golite062009
transcription factor binding	0.98480383054053	bayes_pls_golite062009
transcription cofactor activity	0.86435821849168	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: