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View Structure Prediction Details

Protein: MMS4
Organism: Saccharomyces cerevisiae
Length: 691 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MMS4.

Description E-value Query
Range
Subject
Range
EME1_ASHGO - Crossover junction endonuclease EME1 OS=Ashbya gossypii GN=EME1 PE=3 SV=1
EME1_ASHGO - Crossover junction endonuclease EME1 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 ...
365.0 [0..54] [690..42]

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Predicted Domain #1
Region A:
Residues: [1-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQIVDFVED KDSRNDASIQ IIDGPSNVEI IALSESMDQD ECKRAHVSSA EMIPSSPQRK  60
   61 SVSNDVENVD LNKSIELSAP FFQDISISKL DDFSTTVNSI IDSSLRNENN AKGNAKKLLD 120
  121 DLISDEWSAD LESSGKKHNK SQYNLRDIAE KWGVQSLKNP EPIAVDCEYK TQGIGKTNSD 180
  181 ISDSPKSQIG AADILFDFPL SPVKHENPTE EKHNSIANEN SSPDNSLKPA GKQNHGEDGT 240
  241 SMAKRVYNKG EDEQEHLPKG KKRTIALSRT LINSTKLPDT VELNLSKFLD SSDSITTDVL 300
  301 STPAKGSNIV RTGSQPIFSN ANCFQEAKRS KTLTAEDPKC TKNTAREVSQ LENYIAYGQY 360
  361 YTREDSKNKI RHLLKENKNA FKRVNQIYRD NIKA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.28
Match: 1h1kI
Description: THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [395-456]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSQMIIEFSP SLLQLFKKGD SDLQQQLAPA VVQSSYNDSM PLLRFLRKCD SIYDFSNDFY  60
   61 YP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [457-691]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CDPKIVEENV LILYYDAQEF FEQYTSQKKE LYRKIRFFSK NGKHVILILS DINKLKRAIF  60
   61 QLENEKYKAR VEQRLSGTEE ALRPRSKKSS QVGKLGIKKF DLEQRLRFID REWHVKIHTV 120
  121 NSHMEFINSL PNLVSLIGKQ RMDPAIRYMK YAHLNVKSAQ DSTETLKKTF HQIGRMPEMK 180
  181 ANNVVSLYPS FQSLLEDIEK GRLQSDNEGK YLMTEAVEKR LYKLFTCTDP NDTIE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.6
Match: 2bgwA
Description: XPF from Aeropyrum pernix, complex with DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
four-way junction helicase activity 9.97778352333441 bayes_pls_golite062009
DNA helicase activity 7.39534793109438 bayes_pls_golite062009
endodeoxyribonuclease activity 3.3215200974849 bayes_pls_golite062009
single-stranded DNA specific endodeoxyribonuclease activity 3.18118446093396 bayes_pls_golite062009
deoxyribonuclease activity 3.15144163151183 bayes_pls_golite062009
excinuclease ABC activity 2.93145997831744 bayes_pls_golite062009
DNA binding 2.86703202962507 bayes_pls_golite062009
nucleic acid binding 2.70608150305499 bayes_pls_golite062009
structure-specific DNA binding 2.54099670773663 bayes_pls_golite062009
single-stranded DNA binding 2.43123013915603 bayes_pls_golite062009
binding 2.15665005558542 bayes_pls_golite062009
helicase activity 1.95147423101621 bayes_pls_golite062009
damaged DNA binding 1.93355995630071 bayes_pls_golite062009
nuclease activity 1.53464565125134 bayes_pls_golite062009
endonuclease activity 1.2384221353329 bayes_pls_golite062009
pyrophosphatase activity 0.868370062080145 bayes_pls_golite062009
catalytic activity 0.776505703815067 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.757551245363434 bayes_pls_golite062009
protein binding 0.687937183662529 bayes_pls_golite062009
double-stranded DNA binding 0.593379763919056 bayes_pls_golite062009
DNA strand annealing activity 0.591712648797139 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle